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李剑
Life Science
厦门大学
福建
Language: 英语, 中文
疟原虫
宿主互作
毒力
分子机制
抗药性
遗传基础
疟疾
寄生虫发育
阶段
控制机制
Areas of Focus
- 疟原虫-宿主互作的致病性毒力分子机制
- 疟原虫抗药的遗传机制
- 疟原虫时期发育的分子机制
Work Experience
- 2019-至今 - 厦门大学 - 副教授
- 2011-2019 - 厦门大学 - 助理教授
- 2009-2011 - 美国国立卫生研究院 - 联培博士生
Academic Background & Achievements
- 2005-2011 博士：厦门大学，生物化学与分子生物学
- 2000-2004 学士：南昌大学，生物科学
Publications
- Deaggregation of mutant Plasmodium yoelii de-ubiquitinase UBP1 alters MDR1 localization to confer multidrug resistance., Xu R#, Lin L#, Jiao Z, Liang R, Guo Y, Zhang Y, Shang X, Wang Y, Wang X, Yao L, Liu S, Deng X, Yuan J*, Su X-z*, Li J*, 2024
- Human ApoE2 protects mice against Plasmodium berghei ANKA experimental cerebral malaria., Liang R#, Rao H#, Pang Q, Xu R, Jiao Z, Lin L, Li L, Zhong L, Zhang Y, Guo Y, Xiao N, Liu S, Chen X-F*, Su X-z*, Li J*, 2023
- Inner membrane complex proteomics reveals a palmitoylation regulation critical for intraerythrocytic development of malaria parasite., Qian P#, Wang X#, Zhong C-Q#, Wang J#, Cai M, Nguitragoo W, Li J*, Cui H*, Yuan J*, 2022
- The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis., Zhang C#, Zhong T#, Li Y#, Li X#, Yuan X, Liu L, Wu W, Wu J, Wu Y, Liang R, Xie X, Kang C, Liu Y, Lai Z, Xiao J, Tang Z, Jin R, Wang Y, Xiao Y, Zhang J, Li J*, Liu Q*, Sun Z*, Zhong J*, 2021
- Generation and functional characterisation of Plasmodium yoelii csp deletion mutants using a microhomology-based CRISPR/Cas9 method., Xu R, Liu Y, Fan R, Liang R, Yue L, Liu S, Su X-z*, Li J*, 2019
- A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence., Nair SC#, Xu R#, Pattaradilokrat S, Wu J, Qi Y, Zilversmit M, Ganesan S, Nagarajan V, Eastman RT, Orandle MS, Tan JC, Myers TG, Liu S, Long CA, Li J*, Su X-z*, 2017
- Artemisinin and malaria: Current understandings of drug activation, action, and resistance., Su XZ*, Li J., 2017
- Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality., Yu X#, Cai B#, Wang M, Tan P, Ding X, Wu J, Li J, Li Q, Liu P, Xing C, Wang HY, Su X-z*, Wang R-F*, 2016
- UTR introns, antisense RNA and differentially spliced transcripts between Plasmodium yoelii subspecies., Li J*, Cai B, Qi Y, Zhao W, Liu J, Xu R, Pang Q, Tao Z, Hong L, Liu S, Leerkes M, Quiñones M, Su X-z*, 2016
- Regulation of Plasmodium yoelii Oocyst Development by Strain- and Stage-Specific Small-Subunit rRNA., Qi Y, Zhu F, Eastman RT, Fu Y, Zilversmit M, Pattaradilokrat S, Hong L, Liu S, McCutchan TF, Pan W, Xu W, Li J*, Huang F*, Su X-z*, 2015
- Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality., Wu J, Tian L, Yu X, Pattaradilokrat S, Li J, Wang M, Yu W, Qi Y, Zeituni AE, Nair SC, Crampton SP, Orandle MS, Bolland SM, Qi CF, Long CA, Myers TG, Coligan JE, Wang R*, Su X-z*, 2014
- Chemical genomics for studying parasite gene function and interaction., Li J, Yuan J, Chen CC, Inglese J, Su X-z*, 2013
- Linkage maps from multiple genetic crosses and loci linked to growth-related virulent phenotype in Plasmodium yoelii., Li J#, Pattaradilokrat S#, Zhu F#, Jiang H, Liu S, Hong L, Fu Y, Koo L, Xu W, Pan W, Carlton JM, Kaneko O, Carter R, Wootton JC, Su X-z*, 2011
- Hundreds of microsatellites for genotyping Plasmodium yoelii parasites., Li J, Zhang Y, Liu S, Hong L, Sullivan M, McCutchan TF, Carlton JM, Su X-z*, 2009
- Typing Plasmodium yoelii microsatellites using a simple and affordable fluorescent labeling method., Li J, Zhang Y, Sullivan M, Hong L, Huang L, Lu F, McCutchan TF, Su X-z*, 2007
