Professor | 李剑 | 数字化转型顾问

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Name	李剑
Contact Information	jianli_204@xmu.edu.cn
Language ability	英语, 中文
Province	福建

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Name

李剑

Contact Information

jianli_204@xmu.edu.cn

Language ability

英语, 中文

Province

福建

University/Lab Affiliation and Title	厦门大学
Faculty	Life Sciences
Academic Background & Achievements	2005-2011 博士：厦门大学，生物化学与分子生物学 2000-2004 学士：南昌大学，生物科学
Work Experience	2019-至今 - 厦门大学 - 副教授 2011-2019 - 厦门大学 - 助理教授 2009-2011 - 美国国立卫生研究院 - 联培博士生

University/Lab Affiliation and Title

厦门大学

Faculty

Life Sciences

Academic Background & Achievements

2005-2011 博士：厦门大学，生物化学与分子生物学
2000-2004 学士：南昌大学，生物科学

Work Experience

2019-至今 - 厦门大学 - 副教授
2011-2019 - 厦门大学 - 助理教授
2009-2011 - 美国国立卫生研究院 - 联培博士生

Areas of Focus	疟原虫-宿主互作的致病性毒力分子机制疟原虫抗药的遗传机制疟原虫时期发育的分子机制
Publications	Deaggregation of mutant Plasmodium yoelii de-ubiquitinase UBP1 alters MDR1 localization to confer multidrug resistance., Xu R#, Lin L#, Jiao Z, Liang R, Guo Y, Zhang Y, Shang X, Wang Y, Wang X, Yao L, Liu S, Deng X, Yuan J, Su X-z, Li J, 2024 Human ApoE2 protects mice against Plasmodium berghei ANKA experimental cerebral malaria., Liang R#, Rao H#, Pang Q, Xu R, Jiao Z, Lin L, Li L, Zhong L, Zhang Y, Guo Y, Xiao N, Liu S, Chen X-F, Su X-z, Li J, 2023 Inner membrane complex proteomics reveals a palmitoylation regulation critical for intraerythrocytic development of malaria parasite., Qian P#, Wang X#, Zhong C-Q#, Wang J#, Cai M, Nguitragoo W, Li J, Cui H, Yuan J, 2022 The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis., Zhang C#, Zhong T#, Li Y#, Li X#, Yuan X, Liu L, Wu W, Wu J, Wu Y, Liang R, Xie X, Kang C, Liu Y, Lai Z, Xiao J, Tang Z, Jin R, Wang Y, Xiao Y, Zhang J, Li J, Liu Q, Sun Z, Zhong J, 2021 Generation and functional characterisation of Plasmodium yoelii csp deletion mutants using a microhomology-based CRISPR/Cas9 method., Xu R, Liu Y, Fan R, Liang R, Yue L, Liu S, Su X-z, Li J, 2019 A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence., Nair SC#, Xu R#, Pattaradilokrat S, Wu J, Qi Y, Zilversmit M, Ganesan S, Nagarajan V, Eastman RT, Orandle MS, Tan JC, Myers TG, Liu S, Long CA, Li J, Su X-z, 2017 Artemisinin and malaria: Current understandings of drug activation, action, and resistance., Su XZ, Li J., 2017 Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality., Yu X#, Cai B#, Wang M, Tan P, Ding X, Wu J, Li J, Li Q, Liu P, Xing C, Wang HY, Su X-z, Wang R-F, 2016 UTR introns, antisense RNA and differentially spliced transcripts between Plasmodium yoelii subspecies., Li J, Cai B, Qi Y, Zhao W, Liu J, Xu R, Pang Q, Tao Z, Hong L, Liu S, Leerkes M, Quiñones M, Su X-z, 2016 Regulation of Plasmodium yoelii Oocyst Development by Strain- and Stage-Specific Small-Subunit rRNA., Qi Y, Zhu F, Eastman RT, Fu Y, Zilversmit M, Pattaradilokrat S, Hong L, Liu S, McCutchan TF, Pan W, Xu W, Li J, Huang F, Su X-z, 2015 Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality., Wu J, Tian L, Yu X, Pattaradilokrat S, Li J, Wang M, Yu W, Qi Y, Zeituni AE, Nair SC, Crampton SP, Orandle MS, Bolland SM, Qi CF, Long CA, Myers TG, Coligan JE, Wang R, Su X-z, 2014 Chemical genomics for studying parasite gene function and interaction., Li J, Yuan J, Chen CC, Inglese J, Su X-z, 2013 Linkage maps from multiple genetic crosses and loci linked to growth-related virulent phenotype in Plasmodium yoelii., Li J#, Pattaradilokrat S#, Zhu F#, Jiang H, Liu S, Hong L, Fu Y, Koo L, Xu W, Pan W, Carlton JM, Kaneko O, Carter R, Wootton JC, Su X-z, 2011 Hundreds of microsatellites for genotyping Plasmodium yoelii parasites., Li J, Zhang Y, Liu S, Hong L, Sullivan M, McCutchan TF, Carlton JM, Su X-z, 2009 Typing Plasmodium yoelii microsatellites using a simple and affordable fluorescent labeling method., Li J, Zhang Y, Sullivan M, Hong L, Huang L, Lu F, McCutchan TF, Su X-z*, 2007

Areas of Focus

疟原虫-宿主互作的致病性毒力分子机制
疟原虫抗药的遗传机制
疟原虫时期发育的分子机制

Publications

Deaggregation of mutant Plasmodium yoelii de-ubiquitinase UBP1 alters MDR1 localization to confer multidrug resistance., Xu R#, Lin L#, Jiao Z, Liang R, Guo Y, Zhang Y, Shang X, Wang Y, Wang X, Yao L, Liu S, Deng X, Yuan J*, Su X-z*, Li J*, 2024
Human ApoE2 protects mice against Plasmodium berghei ANKA experimental cerebral malaria., Liang R#, Rao H#, Pang Q, Xu R, Jiao Z, Lin L, Li L, Zhong L, Zhang Y, Guo Y, Xiao N, Liu S, Chen X-F*, Su X-z*, Li J*, 2023
Inner membrane complex proteomics reveals a palmitoylation regulation critical for intraerythrocytic development of malaria parasite., Qian P#, Wang X#, Zhong C-Q#, Wang J#, Cai M, Nguitragoo W, Li J*, Cui H*, Yuan J*, 2022
The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis., Zhang C#, Zhong T#, Li Y#, Li X#, Yuan X, Liu L, Wu W, Wu J, Wu Y, Liang R, Xie X, Kang C, Liu Y, Lai Z, Xiao J, Tang Z, Jin R, Wang Y, Xiao Y, Zhang J, Li J*, Liu Q*, Sun Z*, Zhong J*, 2021
Generation and functional characterisation of Plasmodium yoelii csp deletion mutants using a microhomology-based CRISPR/Cas9 method., Xu R, Liu Y, Fan R, Liang R, Yue L, Liu S, Su X-z*, Li J*, 2019
A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence., Nair SC#, Xu R#, Pattaradilokrat S, Wu J, Qi Y, Zilversmit M, Ganesan S, Nagarajan V, Eastman RT, Orandle MS, Tan JC, Myers TG, Liu S, Long CA, Li J*, Su X-z*, 2017
Artemisinin and malaria: Current understandings of drug activation, action, and resistance., Su XZ*, Li J., 2017
Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality., Yu X#, Cai B#, Wang M, Tan P, Ding X, Wu J, Li J, Li Q, Liu P, Xing C, Wang HY, Su X-z*, Wang R-F*, 2016
UTR introns, antisense RNA and differentially spliced transcripts between Plasmodium yoelii subspecies., Li J*, Cai B, Qi Y, Zhao W, Liu J, Xu R, Pang Q, Tao Z, Hong L, Liu S, Leerkes M, Quiñones M, Su X-z*, 2016
Regulation of Plasmodium yoelii Oocyst Development by Strain- and Stage-Specific Small-Subunit rRNA., Qi Y, Zhu F, Eastman RT, Fu Y, Zilversmit M, Pattaradilokrat S, Hong L, Liu S, McCutchan TF, Pan W, Xu W, Li J*, Huang F*, Su X-z*, 2015
Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality., Wu J, Tian L, Yu X, Pattaradilokrat S, Li J, Wang M, Yu W, Qi Y, Zeituni AE, Nair SC, Crampton SP, Orandle MS, Bolland SM, Qi CF, Long CA, Myers TG, Coligan JE, Wang R*, Su X-z*, 2014
Chemical genomics for studying parasite gene function and interaction., Li J, Yuan J, Chen CC, Inglese J, Su X-z*, 2013
Linkage maps from multiple genetic crosses and loci linked to growth-related virulent phenotype in Plasmodium yoelii., Li J#, Pattaradilokrat S#, Zhu F#, Jiang H, Liu S, Hong L, Fu Y, Koo L, Xu W, Pan W, Carlton JM, Kaneko O, Carter R, Wootton JC, Su X-z*, 2011
Hundreds of microsatellites for genotyping Plasmodium yoelii parasites., Li J, Zhang Y, Liu S, Hong L, Sullivan M, McCutchan TF, Carlton JM, Su X-z*, 2009
Typing Plasmodium yoelii microsatellites using a simple and affordable fluorescent labeling method., Li J, Zhang Y, Sullivan M, Hong L, Huang L, Lu F, McCutchan TF, Su X-z*, 2007

疟原虫宿主互作毒力分子机制抗药性遗传基础疟疾寄生虫发育阶段控制机制

白洋 - 北京大学

徐伟 - 中国科学院大学

陆勇军 - 中山大学

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