Professor | Qiao Wu | Asia Growth Partners

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Name	Qiao Wu
Contact Information	qiaow@xmu.edu.cn
Language ability	English, Chinese
Province	Fujian

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Name

Qiao Wu

Contact Information

qiaow@xmu.edu.cn

Language ability

English, Chinese

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	1992 - M.S. in Cell Biology: Xiamen University 1996 - Ph.D. in Cell Biology: Xiamen University
Work Experience	2001 to Present - Xiamen University, School of Life Sciences - Professor
Awards	December 2021: Advanced Model Figure of Xiamen Special Economic Zone Construction June 2021: Provincial Course Ideological and Political Demonstration Project April 2021: Fujian May 1st Labor Medal June 2020: Xiamen Top Ten Touching Figures Nomination December 2019: Most Beautiful Scientist of Fujian Province June 2019: Outstanding Communist Party Member of Xiamen Education Committee September 2018: Selected as a Teacher Party Branch Secretary January 2018: Selected as a Huang Danian-style Teacher Team October 2018: Fujian Natural Science Award First Prize November 2015: State Council Special Allowance October 2014: Leading Talent in Scientific and Technological Innovation September 2014: Contribution Award for Overseas Chinese January 2013: Fujian Natural Science Award First Prize January 2013: WuXi AppTec Life Chemistry Research Award March 2012: National Women's Advanced Individual February 2012: National March 8th Red Banner Holder October 2011: Fujian March 8th Red Banner Holder

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

1992 - M.S. in Cell Biology: Xiamen University
1996 - Ph.D. in Cell Biology: Xiamen University

Work Experience

2001 to Present - Xiamen University, School of Life Sciences - Professor

Awards

December 2021: Advanced Model Figure of Xiamen Special Economic Zone Construction
June 2021: Provincial Course Ideological and Political Demonstration Project
April 2021: Fujian May 1st Labor Medal
June 2020: Xiamen Top Ten Touching Figures Nomination
December 2019: Most Beautiful Scientist of Fujian Province
June 2019: Outstanding Communist Party Member of Xiamen Education Committee
September 2018: Selected as a Teacher Party Branch Secretary
January 2018: Selected as a Huang Danian-style Teacher Team
October 2018: Fujian Natural Science Award First Prize
November 2015: State Council Special Allowance
October 2014: Leading Talent in Scientific and Technological Innovation
September 2014: Contribution Award for Overseas Chinese
January 2013: Fujian Natural Science Award First Prize
January 2013: WuXi AppTec Life Chemistry Research Award
March 2012: National Women's Advanced Individual
February 2012: National March 8th Red Banner Holder
October 2011: Fujian March 8th Red Banner Holder

Areas of Focus	Nuclear receptors and their roles in cell proliferation and cell death Nuclear receptor associated interactions, protein modifications, and regulatory pathways Molecular basis of nuclear receptor function in tumor, diabetes, obesity and inflammation Nuclear receptors as the target for the design and development of therapeutics to treat cancerous and metabolic diseases
Publications	Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P, Ai YL, Wang WJ, Liu FJ, Fang W, Chen HZ, Wu LZ, Hong XH, Zhu YK, Zhang CX, Liu LY, Hong WB, Zhou B, Chen QT, Wu Q, 2023 Therapeutic potency of compound RMY-205 for pulmonary fibrosis induced by SARS-CoV-2 nucleocapsid protein, Zhang ZY, Ju CY, Wu LZ, Yan H, Hong WB, Chen HZ, Yang PB, Wang BR, Gou T, Chen XY, Jiang ZH, Wang WJ, Lin T, Li FN, Wu Q, 2023 HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma, Chen QT, Zhang ZY, Huang QL, Chen HZ, Hong WB, Lin T, Zhao WX, Wang XM, Ju CY, Wu LZ, Huang YY, Hou PP, Wang WJ, Zhou D, Deng X, Wu Q, 2022 The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8, Zhang JY, Zhou B, Sun RY, Ai YL, Cheng K, Li FN, Wang BR, Liu FJ, Jiang ZH, Wang WJ, Zhou D, Chen HZ, Wu Q, 2021 Blocking PPARgamma interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression, Yang PB, Hou PP, Liu FY, Hong WB, Chen HZ, Sun XY, Li P, Zhang Y, Ju CY, Luo LJ, Wu SF, Zhou JX, Wang ZJ, He JP, Li L, Zhao TJ, Deng X, Lin T, Wu Q, 2020 Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment, Hou PP, Luo LJ, Chen HZ, Chen QT, Bian XL, Wu SF, Zhou JX, Zhao WX, Liu JM, Wang XM, Zhang ZY, Yao LM, Chen Q, Zhou D, Wu Q, 2020 Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis, Zhou B, Zhang JY, Liu XS, Chen HZ, Ai YL, Cheng K, Sun RY, Zhou D, Han J, Wu Q, 2018 Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation, Li XX, Wang ZJ, Zheng Y, Guan YF, Yang PB, Chen X, Peng C, He JP, Ai YL, Wu SF, Chien KY, Wu Q, Chen HZ, 2018 Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation, Bian XL, Chen HZ, Yang PB, Li YP, Zhang FN, Zhang JY, Wang WJ, Zhao WX, Zhang S, Chen QT, Zheng Y, Sun XY, Wang XM, Chien KY, Wu Q, 2017 Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation, Li L, Liu Y, Chen HZ, Li FW, Wu JF, Zhang HK, He JP, Xing YZ, Chen Y, Wang WJ, Tian XY, Li AZ, Zhang Q, Huang PQ, Han J, Lin T, Wu Q, 2015 Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway, Wang WJ, Wang Y, Chen HZ, Xing YZ, Li FW, Zhang Q, Zhou B, Zhang HK, Zhang J, Bian XL, Li L, Liu Y, Zhao BX, Chen Y, Wu R, Li AZ, Yao LM, Chen P, Zhang Y, Tian XY, Beermann F, Wu M, Han J, Huang PQ, Lin T, Wu Q, 2014 The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK, Zhan YY, Chen Y, Zhang Q, Zhuang JJ, Tian M, Chen HZ, Zhang LR, Zhang HK, He JP, Wang WJ, Wu R, Wang Y, Shi C, Yang K, Li AZ, Xin YZ, Li TY, Yang JY, Zheng ZH, Yu CD, Lin SC, Chang C, Huang PQ, Lin T, Wu Q, 2012 Cytosporone B is an agonist for nuclear orphan receptor Nur77, Zhan YY, Du XP, Chen HZ, Liu JJ, Zhao BX, Huang DH, Li GD, Xu QY, Zhang MQ, Weimer BC, Chen D, Cheng Z, Zhang LR, Li QX, Li SW, Zheng ZH, Song SY, Huang YJ, Ye ZY, Su WJ, Lin SC, Shen YM, Wu Q, 2008

Areas of Focus

Nuclear receptors and their roles in cell proliferation and cell death
Nuclear receptor associated interactions, protein modifications, and regulatory pathways
Molecular basis of nuclear receptor function in tumor, diabetes, obesity and inflammation
Nuclear receptors as the target for the design and development of therapeutics to treat cancerous and metabolic diseases

Publications

Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P, Ai YL, Wang WJ, Liu FJ, Fang W, Chen HZ, Wu LZ, Hong XH, Zhu YK, Zhang CX, Liu LY, Hong WB, Zhou B, Chen QT, Wu Q, 2023
Therapeutic potency of compound RMY-205 for pulmonary fibrosis induced by SARS-CoV-2 nucleocapsid protein, Zhang ZY, Ju CY, Wu LZ, Yan H, Hong WB, Chen HZ, Yang PB, Wang BR, Gou T, Chen XY, Jiang ZH, Wang WJ, Lin T, Li FN, Wu Q, 2023
HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma, Chen QT, Zhang ZY, Huang QL, Chen HZ, Hong WB, Lin T, Zhao WX, Wang XM, Ju CY, Wu LZ, Huang YY, Hou PP, Wang WJ, Zhou D, Deng X, Wu Q, 2022
The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8, Zhang JY, Zhou B, Sun RY, Ai YL, Cheng K, Li FN, Wang BR, Liu FJ, Jiang ZH, Wang WJ, Zhou D, Chen HZ, Wu Q, 2021
Blocking PPARgamma interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression, Yang PB, Hou PP, Liu FY, Hong WB, Chen HZ, Sun XY, Li P, Zhang Y, Ju CY, Luo LJ, Wu SF, Zhou JX, Wang ZJ, He JP, Li L, Zhao TJ, Deng X, Lin T, Wu Q, 2020
Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment, Hou PP, Luo LJ, Chen HZ, Chen QT, Bian XL, Wu SF, Zhou JX, Zhao WX, Liu JM, Wang XM, Zhang ZY, Yao LM, Chen Q, Zhou D, Wu Q, 2020
Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis, Zhou B, Zhang JY, Liu XS, Chen HZ, Ai YL, Cheng K, Sun RY, Zhou D, Han J, Wu Q, 2018
Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation, Li XX, Wang ZJ, Zheng Y, Guan YF, Yang PB, Chen X, Peng C, He JP, Ai YL, Wu SF, Chien KY, Wu Q, Chen HZ, 2018
Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation, Bian XL, Chen HZ, Yang PB, Li YP, Zhang FN, Zhang JY, Wang WJ, Zhao WX, Zhang S, Chen QT, Zheng Y, Sun XY, Wang XM, Chien KY, Wu Q, 2017
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation, Li L, Liu Y, Chen HZ, Li FW, Wu JF, Zhang HK, He JP, Xing YZ, Chen Y, Wang WJ, Tian XY, Li AZ, Zhang Q, Huang PQ, Han J, Lin T, Wu Q, 2015
Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway, Wang WJ, Wang Y, Chen HZ, Xing YZ, Li FW, Zhang Q, Zhou B, Zhang HK, Zhang J, Bian XL, Li L, Liu Y, Zhao BX, Chen Y, Wu R, Li AZ, Yao LM, Chen P, Zhang Y, Tian XY, Beermann F, Wu M, Han J, Huang PQ, Lin T, Wu Q, 2014
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK, Zhan YY, Chen Y, Zhang Q, Zhuang JJ, Tian M, Chen HZ, Zhang LR, Zhang HK, He JP, Wang WJ, Wu R, Wang Y, Shi C, Yang K, Li AZ, Xin YZ, Li TY, Yang JY, Zheng ZH, Yu CD, Lin SC, Chang C, Huang PQ, Lin T, Wu Q, 2012
Cytosporone B is an agonist for nuclear orphan receptor Nur77, Zhan YY, Du XP, Chen HZ, Liu JJ, Zhao BX, Huang DH, Li GD, Xu QY, Zhang MQ, Weimer BC, Chen D, Cheng Z, Zhang LR, Li QX, Li SW, Zheng ZH, Song SY, Huang YJ, Ye ZY, Su WJ, Lin SC, Shen YM, Wu Q, 2008

Nuclear Receptors Cell Proliferation Cell Death Protein Interactions Protein Modifications Regulatory Pathways Tumor Diabetes Obesity Inflammation

Shuhong Qi - Huazhong University of Science and Technology

Daichao Xu - University of Chinese Academy of Sciences

Chengyu Zou - University of Chinese Academy of Sciences

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