Professor | Jie Zhang | Asia Growth Partners

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Name	Jie Zhang
Contact Information	jiezhang@xmu.edu.cn
Language ability	Chinese, English
Province	Fujian

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Name

Jie Zhang

Contact Information

jiezhang@xmu.edu.cn

Language ability

Chinese, English

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	1997-2001 Bachelor: Sichuan University, College of Life Sciences 2001-2006 Doctorate: Institute of Biophysics, Chinese Academy of Sciences Recipient of National Outstanding Youth Science Fund Recipient of National Excellent Youth Science Fund Recipient of Ministry of Education New Century Excellent Talents Recipient of Fujian Province Outstanding Youth Fund
Work Experience	2006-2011 - New Jersey State University - Postdoctoral Research Assistant 2011-Present - Xiamen University - Distinguished Professor
Awards	National Outstanding Youth Science Fund National Excellent Youth Science Fund Ministry of Education New Century Excellent Talents Fujian Province Outstanding Youth Fund

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

1997-2001 Bachelor: Sichuan University, College of Life Sciences
2001-2006 Doctorate: Institute of Biophysics, Chinese Academy of Sciences
Recipient of National Outstanding Youth Science Fund
Recipient of National Excellent Youth Science Fund
Recipient of Ministry of Education New Century Excellent Talents
Recipient of Fujian Province Outstanding Youth Fund

Work Experience

2006-2011 - New Jersey State University - Postdoctoral Research Assistant
2011-Present - Xiamen University - Distinguished Professor

Awards

National Outstanding Youth Science Fund
National Excellent Youth Science Fund
Ministry of Education New Century Excellent Talents
Fujian Province Outstanding Youth Fund

Areas of Focus	Pathogenesis and drug development for major brain diseases such as Alzheimer's disease (AD), depression, autism, and postoperative cognitive dysfunction
Publications	Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence., Chow HM, Shi Meng, Cheng A, Gao Y, Chen G, Song X, So RWL, Jie Zhang, Karl Herrup, 2019 Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation., Lige Leng, Kai Zhuang, Zeyue Liu, Changquan Huang, Yuehong Gao, Guimiao Chen, Hui Lin, Yu Hu, Di Wu, Meng Shi, Wenting Xie, Hao Sun, Zhicheng Shao, Huifang Li, Kunkun Zhang, Wei Mo, Timothy Y. Huang, Maoqiang Xue, Zengqiang Yuan, Xia Zhang, Guojun Bu, Huaxi Xu, Qi Xu,* and Jie Zhang, 2018 Neuron-specific menin deletion leads to synaptic dysfunction and cognitive impairment by modulating p35 expression., Kai Zhuang, Changquan Huang, Lige Leng, Honghua Zheng, Yuehong Gao, Guimiao Chen, Zhilin Ji, Hao Sun, Yu Hu, Di Wu, Meng Shi, Huifang Li, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Guojun Bu, Timothy Y. Huang, Huaxi Xu, Jie Zhang, 2018 CDK5-dependent BAG3 degradation modulates synaptic protein turnover., Jiechao Zhou, Hei-Man Chow, Yan Liu, Di Wu, Meng Shi, Jieyin Li, Lei Wen, Yuehong Gao, Guimiao Chen, Kai Zhuang, Hui Lin, Guanyun Zhang, Wenting Xie, Huifang Li, Lige Leng, Mengdan Wang, Naizhen Zheng, Hao Sun, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Timothy Y. Huang, Guojun Bu, Huaxi Xu, Zengqiang Yuan, Karl Herrup, Jie Zhang, 2020 Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death., Guo D, Xie W, Xiong P, Li H, Wang S, Chen G, Gao Y, Zhou J, Zhang Y, Bu G, Maoqiang Xue, M, Jie Zhang, 2018 CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis., Wang F, Zhao W, Gao Y, Zhou J, Li H, Zhang G, Guo D, Xie C, Li J, Zhenyu Yin, Zhang Jie, 2019 The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death., Jiechao Zhou, Huifang Li, Xiaoping Li, Guanyun Zhang, Yaqiong Niu, Zengqiang Yuan, Karl Herrup, YunWu Zhang, Guojun Bu, Huaxi Xu, Jie Zhang, 2015 CDK5 activator protein p25 preferentially binds and activates GSK3β., Chow HM, Guo D, Zhou JC, Zhang GY, Li HF, Herrup Karl, Zhang Jie, 2014 Cyclin dependent kinase 5 decreases in gastric cancer and its nuclear accumulation suppresses gastric tumorigenesis., Longlong Cao, Jiechao Zhou, Junrong Zhang, Sijin Wu, Xintao Yang, Xin Zhao, Huifang Li, Ming Luo, Qian Yu, Jianwei Xie, Ping Li, Xiaoqing Hu, Chaohui Zheng, Guojun Bu, Yun-wu Zhang, Huaxi Xu, Yongliang Yang, Changming Huang, Jie Zhang, 2015 Structural Bioinformatics-Based Identification of EGFR Inhibitor Gefitinib as a Putative Lead Compound for BACE., Mingshan Niu, Jin Hu, Sijin Wu, Xiaoe Zhang, Huaxi Xu, Yunwu Zhang, Jie Zhang, Yongliang Yang , 2014 Tailoring 3,3'-dihydroxyisorenieratene to hydroxystilbene: finding a resveratrol analogue with increased antiproliferation activity and cell selectivity., Kang YF, Yan WJ, Zhou TW, Dai F, Li XZ, Bao XZ, Du YT, Yuan CH, Wang HB, Ren XR, Liu Q, Jin XL, Zhou B, Zhang Jie, 2014 Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase., Zhang Jie, Li Huifang, Zhou Tingwen, Zhou Jiechao, Herrup Karl, 2012 Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons., Zhang Jie & Herrup K, 2011 Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex., Zhang Jie, Huifang Li, Herrup Karl, 2010 Cdk5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation., Zhang Jie, Huifang Li, Herrup Karl, 2010 Nuclear localization of Cdk5 is a key determinant in the post-mitotic state of neurons., Zhang Jie, Cicero, S.A., Wang, L., Romito-Digiacomo, R.R., Yang, Y. and Herrup, K, 2008 Cdk5 and the non-catalytic arrest of the neuronal cell cycle., Zhang Jie, Herrup Karl, 2008 Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model., Liu Qiang, Zhang Jie, Zhu Hua, Qin Chuan, Chen Qi and Zhao Baolu Zhao, 2007 Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis., Zhang Jie, Liu Qiang, Liu Nian-Qing, Li Fu-Liang, Chen Qi, Qin Chuan, Zhu Hua, Huang Yu-Ying, He Wei, Zhao Bao-Lu, 2006

Areas of Focus

Pathogenesis and drug development for major brain diseases such as Alzheimer's disease (AD), depression, autism, and postoperative cognitive dysfunction

Publications

Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence., Chow HM, Shi Meng, Cheng A, Gao Y, Chen G, Song X, So RWL, Jie Zhang*, Karl Herrup*, 2019
Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation., Lige Leng, Kai Zhuang, Zeyue Liu, Changquan Huang, Yuehong Gao, Guimiao Chen, Hui Lin, Yu Hu, Di Wu, Meng Shi, Wenting Xie, Hao Sun, Zhicheng Shao, Huifang Li, Kunkun Zhang, Wei Mo, Timothy Y. Huang, Maoqiang Xue, Zengqiang Yuan, Xia Zhang, Guojun Bu, Huaxi Xu, Qi Xu,* and Jie Zhang*, 2018
Neuron-specific menin deletion leads to synaptic dysfunction and cognitive impairment by modulating p35 expression., Kai Zhuang, Changquan Huang, Lige Leng, Honghua Zheng, Yuehong Gao, Guimiao Chen, Zhilin Ji, Hao Sun, Yu Hu, Di Wu, Meng Shi, Huifang Li, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Guojun Bu, Timothy Y. Huang, Huaxi Xu, Jie Zhang*, 2018
CDK5-dependent BAG3 degradation modulates synaptic protein turnover., Jiechao Zhou, Hei-Man Chow, Yan Liu, Di Wu, Meng Shi, Jieyin Li, Lei Wen, Yuehong Gao, Guimiao Chen, Kai Zhuang, Hui Lin, Guanyun Zhang, Wenting Xie, Huifang Li, Lige Leng, Mengdan Wang, Naizhen Zheng, Hao Sun, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Timothy Y. Huang, Guojun Bu, Huaxi Xu, Zengqiang Yuan, Karl Herrup, Jie Zhang*, 2020
Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death., Guo D, Xie W, Xiong P, Li H, Wang S, Chen G, Gao Y, Zhou J, Zhang Y, Bu G, Maoqiang Xue*, M, Jie Zhang*, 2018
CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis., Wang F, Zhao W, Gao Y, Zhou J, Li H, Zhang G, Guo D, Xie C, Li J, Zhenyu Yin*, Zhang Jie*, 2019
The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death., Jiechao Zhou, Huifang Li, Xiaoping Li, Guanyun Zhang, Yaqiong Niu, Zengqiang Yuan, Karl Herrup, YunWu Zhang, Guojun Bu, Huaxi Xu, Jie Zhang*, 2015
CDK5 activator protein p25 preferentially binds and activates GSK3β., Chow HM, Guo D, Zhou JC, Zhang GY, Li HF, Herrup Karl, Zhang Jie*, 2014
Cyclin dependent kinase 5 decreases in gastric cancer and its nuclear accumulation suppresses gastric tumorigenesis., Longlong Cao, Jiechao Zhou, Junrong Zhang, Sijin Wu, Xintao Yang, Xin Zhao, Huifang Li, Ming Luo, Qian Yu, Jianwei Xie, Ping Li, Xiaoqing Hu, Chaohui Zheng, Guojun Bu, Yun-wu Zhang, Huaxi Xu*, Yongliang Yang*, Changming Huang*, Jie Zhang*, 2015
Structural Bioinformatics-Based Identification of EGFR Inhibitor Gefitinib as a Putative Lead Compound for BACE., Mingshan Niu, Jin Hu, Sijin Wu, Xiaoe Zhang, Huaxi Xu, Yunwu Zhang, Jie Zhang*, Yongliang Yang *, 2014
Tailoring 3,3'-dihydroxyisorenieratene to hydroxystilbene: finding a resveratrol analogue with increased antiproliferation activity and cell selectivity., Kang YF, Yan WJ, Zhou TW, Dai F, Li XZ, Bao XZ, Du YT, Yuan CH, Wang HB, Ren XR, Liu Q, Jin XL, Zhou B*, Zhang Jie*, 2014
Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase., Zhang Jie*, Li Huifang, Zhou Tingwen, Zhou Jiechao, Herrup Karl, 2012
Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons., Zhang Jie & Herrup K, 2011
Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex., Zhang Jie, Huifang Li, Herrup Karl, 2010
Cdk5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation., Zhang Jie, Huifang Li, Herrup Karl, 2010
Nuclear localization of Cdk5 is a key determinant in the post-mitotic state of neurons., Zhang Jie, Cicero, S.A., Wang, L., Romito-Digiacomo, R.R., Yang, Y. and Herrup, K, 2008
Cdk5 and the non-catalytic arrest of the neuronal cell cycle., Zhang Jie, Herrup Karl, 2008
Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model., Liu Qiang*, Zhang Jie*, Zhu Hua, Qin Chuan, Chen Qi and Zhao Baolu Zhao, 2007
Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis., Zhang Jie, Liu Qiang, Liu Nian-Qing, Li Fu-Liang, Chen Qi, Qin Chuan, Zhu Hua, Huang Yu-Ying, He Wei, Zhao Bao-Lu, 2006

Alzheimer'S Disease Depression Autism Cognitive Dysfunction Pathogenesis Drug Development Neuroinflammation Neuronal Cell Cycle Small Molecule Compounds Chinese Population

Yujun Hou - Tongji University

Qin Cao - Shanghai Jiao Tong University

Kefu Liu - Central South University

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