Areas of Focus
- Structural analysis of amyloid fibrils using cryo-EM
- Design of fibrillation inhibitors based on structure
- Development of diagnostic and therapeutic drugs for Alzheimer's disease based on Aβ and its natural receptor interactions
Work Experience
- 2019-2021 - University of California, Los Angeles - Assistant Researcher
- 2013-2019 - University of California, Los Angeles - Postdoctoral Researcher
Academic Background & Achievements
- 2008-2013 PhD in Biochemistry and Molecular Biology, Peking University
- 2013-2019 Postdoctoral Researcher, University of California, Los Angeles
- 2019-2021 Assistant Researcher, University of California, Los Angeles
- Youth Chief Scientist in the National Key R&D Program of China
Publications
- Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM, Cheng, Y., Han, J., Song, M., Zhang S., Cao, Q#., 2023
- Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43, Jiang, Y. X., Cao, Q., Sawaya, M. R., Abskharon, R., Ge, P., DeTure, M., Dickson, D. W., Fu, J. Y., Loo, R. R. O., Loo, J. A., Eisenberg, D. S., 2022
- Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores, Cao, Q., Boyer, D. R., Sawaya, M. R., Abskharon, R., Saelices, L., Nguyen, B.A., Lu J., Murry, K.A., Kandeel, F., Eisenberg, D.S., 2021
- Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils., Cao, Q., Boyer, D. R., Sawaya, M. R., Ge, P., Eisenberg, D.S., 2020
- Cryo-EM structures of four polymorphic TDP-43 amyloid cores., Cao, Q., Boyer, D. R., Sawaya, M. R., Ge, P., Eisenberg, D.S., 2019
- Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design., Cao, Q., Shin, W. S., Chan, H., Vuong, C. K., Dubois, B., Li, B., Murray, K. A., Sawaya, M. R., Feigon, J., Black, D. L., Eisenberg, D. S., Jiang, L., 2018
- Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation., Guenther, E. L., Cao, Q., Trinh, H., Lu, J., Sawaya, M. R., Cascio, D., Boyer, D. R., Rodriguez, J. A., Hughes, M. P., Eisenberg, D. S., 2018
- The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin., Cao, Q., Anderson, D.H., Liang, W., Chou, J., Saelices, L., 2020
- Activation and Regulation of Caspase-6 and Its Role in Neurodegenerative Diseases., Wang, X.-J., Cao, Q., Zhang, Y., Su, X.-D., 2015
- The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays., Cao, Q., Wang, X.-J., Li, L.-F., Su, X.-D., 2014
