Professor | Qin Cao | Asia Growth Partners

Name	Qin Cao
Contact Information	caoqin@sjtu.edu.cn
Language ability	Chinese, English
Province	Shanghai

Name

Qin Cao

Contact Information

caoqin@sjtu.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Shanghai Jiao Tong University
Faculty	Life Sciences
Academic Background & Achievements	2008-2013 PhD in Biochemistry and Molecular Biology, Peking University 2013-2019 Postdoctoral Researcher, University of California, Los Angeles 2019-2021 Assistant Researcher, University of California, Los Angeles Youth Chief Scientist in the National Key R&D Program of China
Work Experience	2019-2021 - University of California, Los Angeles - Assistant Researcher 2013-2019 - University of California, Los Angeles - Postdoctoral Researcher

University/Lab Affiliation and Title

Shanghai Jiao Tong University

Faculty

Life Sciences

Academic Background & Achievements

2008-2013 PhD in Biochemistry and Molecular Biology, Peking University
2013-2019 Postdoctoral Researcher, University of California, Los Angeles
2019-2021 Assistant Researcher, University of California, Los Angeles
Youth Chief Scientist in the National Key R&D Program of China

Work Experience

2019-2021 - University of California, Los Angeles - Assistant Researcher
2013-2019 - University of California, Los Angeles - Postdoctoral Researcher

Areas of Focus	Structural analysis of amyloid fibrils using cryo-EM Design of fibrillation inhibitors based on structure Development of diagnostic and therapeutic drugs for Alzheimer's disease based on Aβ and its natural receptor interactions
Publications	Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM, Cheng, Y., Han, J., Song, M., Zhang S., Cao, Q#., 2023 Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43, Jiang, Y. X., Cao, Q., Sawaya, M. R., Abskharon, R., Ge, P., DeTure, M., Dickson, D. W., Fu, J. Y., Loo, R. R. O., Loo, J. A., Eisenberg, D. S., 2022 Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores, Cao, Q., Boyer, D. R., Sawaya, M. R., Abskharon, R., Saelices, L., Nguyen, B.A., Lu J., Murry, K.A., Kandeel, F., Eisenberg, D.S., 2021 Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils., Cao, Q., Boyer, D. R., Sawaya, M. R., Ge, P., Eisenberg, D.S., 2020 Cryo-EM structures of four polymorphic TDP-43 amyloid cores., Cao, Q., Boyer, D. R., Sawaya, M. R., Ge, P., Eisenberg, D.S., 2019 Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design., Cao, Q., Shin, W. S., Chan, H., Vuong, C. K., Dubois, B., Li, B., Murray, K. A., Sawaya, M. R., Feigon, J., Black, D. L., Eisenberg, D. S., Jiang, L., 2018 Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation., Guenther, E. L., Cao, Q., Trinh, H., Lu, J., Sawaya, M. R., Cascio, D., Boyer, D. R., Rodriguez, J. A., Hughes, M. P., Eisenberg, D. S., 2018 The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin., Cao, Q., Anderson, D.H., Liang, W., Chou, J., Saelices, L., 2020 Activation and Regulation of Caspase-6 and Its Role in Neurodegenerative Diseases., Wang, X.-J., Cao, Q., Zhang, Y., Su, X.-D., 2015 The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays., Cao, Q., Wang, X.-J., Li, L.-F., Su, X.-D., 2014

Areas of Focus

Structural analysis of amyloid fibrils using cryo-EM
Design of fibrillation inhibitors based on structure
Development of diagnostic and therapeutic drugs for Alzheimer's disease based on Aβ and its natural receptor interactions

Publications

Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM, Cheng, Y., Han, J., Song, M., Zhang S., Cao, Q#., 2023
Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43, Jiang, Y. X., Cao, Q., Sawaya, M. R., Abskharon, R., Ge, P., DeTure, M., Dickson, D. W., Fu, J. Y., Loo, R. R. O., Loo, J. A., Eisenberg, D. S., 2022
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores, Cao, Q., Boyer, D. R., Sawaya, M. R., Abskharon, R., Saelices, L., Nguyen, B.A., Lu J., Murry, K.A., Kandeel, F., Eisenberg, D.S., 2021
Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils., Cao, Q., Boyer, D. R., Sawaya, M. R., Ge, P., Eisenberg, D.S., 2020
Cryo-EM structures of four polymorphic TDP-43 amyloid cores., Cao, Q., Boyer, D. R., Sawaya, M. R., Ge, P., Eisenberg, D.S., 2019
Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design., Cao, Q., Shin, W. S., Chan, H., Vuong, C. K., Dubois, B., Li, B., Murray, K. A., Sawaya, M. R., Feigon, J., Black, D. L., Eisenberg, D. S., Jiang, L., 2018
Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation., Guenther, E. L., Cao, Q., Trinh, H., Lu, J., Sawaya, M. R., Cascio, D., Boyer, D. R., Rodriguez, J. A., Hughes, M. P., Eisenberg, D. S., 2018
The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin., Cao, Q., Anderson, D.H., Liang, W., Chou, J., Saelices, L., 2020
Activation and Regulation of Caspase-6 and Its Role in Neurodegenerative Diseases., Wang, X.-J., Cao, Q., Zhang, Y., Su, X.-D., 2015
The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays., Cao, Q., Wang, X.-J., Li, L.-F., Su, X.-D., 2014

Cryo-Em Amyloid Fibrils Structural Analysis Fibrillation Inhibition Small Molecule Design Alzheimer'S Disease Aβ Interactions Lilrb2 Receptor Drug Development Disease Mechanism

Qin Cao - Shanghai Jiao Tong University

Jie Zhang - Xiamen University

Tao Jiang - University of Chinese Academy of Sciences

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