Areas of Focus
- 基于冷冻电镜的淀粉样纤维结构解析
- 基于结构的纤维化抑制剂设计
- 基于Aβ与其天然受体相互作用的阿尔兹海默症诊疗药物研发
Work Experience
- 2019-2021 - 加州大学洛杉矶分校 - 助理研究员
- 2013-2019 - 加州大学洛杉矶分校 - 博士后
Academic Background & Achievements
- 2008-2013 北京大学，生物化学与分子生物学博士
- 2013-2019 加州大学洛杉矶分校，博士后
- 2019-2021 加州大学洛杉矶分校，助理研究员
- 科技部科技创新2030重大项目青年首席科学家
Publications
- Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM, Cheng, Y., Han, J., Song, M., Zhang S., Cao, Q#., 2023
- Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43, Jiang, Y. X., Cao, Q., Sawaya, M. R., Abskharon, R., Ge, P., DeTure, M., Dickson, D. W., Fu, J. Y., Loo, R. R. O., Loo, J. A., Eisenberg, D. S., 2022
- Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores, Cao, Q., Boyer, D. R., Sawaya, M. R., Abskharon, R., Saelices, L., Nguyen, B.A., Lu J., Murry, K.A., Kandeel, F., Eisenberg, D.S., 2021
- Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils., Cao, Q., Boyer, D. R., Sawaya, M. R., Ge, P., Eisenberg, D.S., 2020
- Cryo-EM structures of four polymorphic TDP-43 amyloid cores., Cao, Q., Boyer, D. R., Sawaya, M. R., Ge, P., Eisenberg, D.S., 2019
- Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design., Cao, Q., Shin, W. S., Chan, H., Vuong, C. K., Dubois, B., Li, B., Murray, K. A., Sawaya, M. R., Feigon, J., Black, D. L., Eisenberg, D. S., Jiang, L., 2018
- Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation., Guenther, E. L., Cao, Q., Trinh, H., Lu, J., Sawaya, M. R., Cascio, D., Boyer, D. R., Rodriguez, J. A., Hughes, M. P., Eisenberg, D. S., 2018
- The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin., Cao, Q., Anderson, D.H., Liang, W., Chou, J., Saelices, L., 2020
- Activation and Regulation of Caspase-6 and Its Role in Neurodegenerative Diseases., Wang, X.-J., Cao, Q., Zhang, Y., Su, X.-D., 2015
- The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays., Cao, Q., Wang, X.-J., Li, L.-F., Su, X.-D., 2014
