Professor | 曹骎 | 数字化转型顾问

Name	曹骎
Contact Information	caoqin@sjtu.edu.cn
Language ability	中文, 英语
Province	上海

Name

曹骎

Contact Information

caoqin@sjtu.edu.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	上海交通大学
Faculty	Life Sciences
Academic Background & Achievements	2008-2013 北京大学，生物化学与分子生物学博士 2013-2019 加州大学洛杉矶分校，博士后 2019-2021 加州大学洛杉矶分校，助理研究员科技部科技创新2030重大项目青年首席科学家
Work Experience	2019-2021 - 加州大学洛杉矶分校 - 助理研究员 2013-2019 - 加州大学洛杉矶分校 - 博士后

University/Lab Affiliation and Title

上海交通大学

Faculty

Life Sciences

Academic Background & Achievements

2008-2013 北京大学，生物化学与分子生物学博士
2013-2019 加州大学洛杉矶分校，博士后
2019-2021 加州大学洛杉矶分校，助理研究员
科技部科技创新2030重大项目青年首席科学家

Work Experience

2019-2021 - 加州大学洛杉矶分校 - 助理研究员
2013-2019 - 加州大学洛杉矶分校 - 博士后

Areas of Focus	基于冷冻电镜的淀粉样纤维结构解析基于结构的纤维化抑制剂设计基于Aβ与其天然受体相互作用的阿尔兹海默症诊疗药物研发
Publications	Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM, Cheng, Y., Han, J., Song, M., Zhang S., Cao, Q#., 2023 Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43, Jiang, Y. X., Cao, Q., Sawaya, M. R., Abskharon, R., Ge, P., DeTure, M., Dickson, D. W., Fu, J. Y., Loo, R. R. O., Loo, J. A., Eisenberg, D. S., 2022 Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores, Cao, Q., Boyer, D. R., Sawaya, M. R., Abskharon, R., Saelices, L., Nguyen, B.A., Lu J., Murry, K.A., Kandeel, F., Eisenberg, D.S., 2021 Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils., Cao, Q., Boyer, D. R., Sawaya, M. R., Ge, P., Eisenberg, D.S., 2020 Cryo-EM structures of four polymorphic TDP-43 amyloid cores., Cao, Q., Boyer, D. R., Sawaya, M. R., Ge, P., Eisenberg, D.S., 2019 Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design., Cao, Q., Shin, W. S., Chan, H., Vuong, C. K., Dubois, B., Li, B., Murray, K. A., Sawaya, M. R., Feigon, J., Black, D. L., Eisenberg, D. S., Jiang, L., 2018 Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation., Guenther, E. L., Cao, Q., Trinh, H., Lu, J., Sawaya, M. R., Cascio, D., Boyer, D. R., Rodriguez, J. A., Hughes, M. P., Eisenberg, D. S., 2018 The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin., Cao, Q., Anderson, D.H., Liang, W., Chou, J., Saelices, L., 2020 Activation and Regulation of Caspase-6 and Its Role in Neurodegenerative Diseases., Wang, X.-J., Cao, Q., Zhang, Y., Su, X.-D., 2015 The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays., Cao, Q., Wang, X.-J., Li, L.-F., Su, X.-D., 2014

Areas of Focus

基于冷冻电镜的淀粉样纤维结构解析
基于结构的纤维化抑制剂设计
基于Aβ与其天然受体相互作用的阿尔兹海默症诊疗药物研发

Publications

Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM, Cheng, Y., Han, J., Song, M., Zhang S., Cao, Q#., 2023
Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43, Jiang, Y. X., Cao, Q., Sawaya, M. R., Abskharon, R., Ge, P., DeTure, M., Dickson, D. W., Fu, J. Y., Loo, R. R. O., Loo, J. A., Eisenberg, D. S., 2022
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores, Cao, Q., Boyer, D. R., Sawaya, M. R., Abskharon, R., Saelices, L., Nguyen, B.A., Lu J., Murry, K.A., Kandeel, F., Eisenberg, D.S., 2021
Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils., Cao, Q., Boyer, D. R., Sawaya, M. R., Ge, P., Eisenberg, D.S., 2020
Cryo-EM structures of four polymorphic TDP-43 amyloid cores., Cao, Q., Boyer, D. R., Sawaya, M. R., Ge, P., Eisenberg, D.S., 2019
Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design., Cao, Q., Shin, W. S., Chan, H., Vuong, C. K., Dubois, B., Li, B., Murray, K. A., Sawaya, M. R., Feigon, J., Black, D. L., Eisenberg, D. S., Jiang, L., 2018
Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation., Guenther, E. L., Cao, Q., Trinh, H., Lu, J., Sawaya, M. R., Cascio, D., Boyer, D. R., Rodriguez, J. A., Hughes, M. P., Eisenberg, D. S., 2018
The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin., Cao, Q., Anderson, D.H., Liang, W., Chou, J., Saelices, L., 2020
Activation and Regulation of Caspase-6 and Its Role in Neurodegenerative Diseases., Wang, X.-J., Cao, Q., Zhang, Y., Su, X.-D., 2015
The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays., Cao, Q., Wang, X.-J., Li, L.-F., Su, X.-D., 2014

冷冻电镜淀粉样纤维结构分析纤维化抑制小分子设计阿尔兹海默症 Aβ相互作用 Lilrb2受体药物开发疾病机制

曹骎 - 上海交通大学

江涛 - 中国科学院大学

张华威 - 中国科学院大学

Area of Focus
蛋白质 | 结构 | 功能 | 生物化学 | 分子生物学 | 药物开发 | 冷冻电镜 | 抑制剂 | 通道 | 途径

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