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Liang Liu
Life Science
Xiamen University
Fujian
Language: Chinese, English
Gene Editing
Molecular Diagnostics
Prokaryotic Defense
Viral Immunity
Nucleic Acid
Rna
Structural Biology
Crispr
Cas9
Biochemical Engineering
Areas of Focus
- Development and application of gene editing and molecular diagnostic tools
- Molecular mechanisms of prokaryotic defense systems and viral antagonism of host immunity
- Nucleic acid processing and modification
- Structural biology research on RNA-mediated gene expression and regulation
Work Experience
- 2012-2015 - Visiting Scholar: Peking University
- 2015-2019 - Postdoctoral Fellow/Associate Professor: Chinese Academy of Sciences
- 2019-Present - Professor: School of Life Sciences, Xiamen University
Academic Background & Achievements
- 2010 - B.S. in Bioengineering: South-central University For Nationalities
- 2015 - Ph.D. in Biochemical Engineering: South China University of Technology
- 2018 - Selected for the 4th China Association for Science and Technology Youth Talent Support Project
- 2019 - Selected as Xiamen University Nanqiang Young Top Talent A Class
- 2021 - Received National Excellent Young Scientists Fund
- 2024 - Received Fujian Province Qing Project Support
Publications
- Trans-nuclease activity of Cas9 activated by DNA or RNA target binding., Chen J, Chen Y, Huang L, Lin X, Chen H, Xiang W, Liu L., 2024
- Structural and mechanistic insight into ribosomal ITS2 RNA processing by nuclease-kinase machinery., Chen J, Chen H, Li S, Lin X, Hu R, Zhang K, Liu L., 2024
- Structural basis for MTA1c-mediated DNA N6-adenine methylation., Chen J, Hu R, Chen Y, Lin X, Xiang W, Chen H, Yao C, Liu L., 2022
- Phage AcrⅡA2 DNA Mimicry: Structural Basis of the CRISPR/anti-CRISPR Arms Race., Liu L, Yin M, Wang M, Wang Y., 2019
- The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a., Liu L, Li X, Ma J, Li Z, You L, Wang J, Wang M, Zhang X, Wang Y., 2017
- Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities., Liu L, Li X, Wang J, Yin M, Chen P, Wang M, Li J, Sheng G, Wang Y., 2017
- C2c1-sgRNA Complex Structure Reveals RNA-guided DNA Cleavage Mechanism., Liu L, Chen P, Wang M, Li X, Wang J, Yin M, Wang Y., 2017
- Active-State Structures of a Small Heat-Shock Protein Revealed a Molecular Switch for Chaperone Function., Liu L, Chen JY, Yang B, Wang FH, Wang YH, Yun CH., 2015
- Crystal structure and function of an unusual dimeric Hsp20.1 provide insight into the thermal protection mechanism of small heat shock proteins., Liu L, Chen J, Yang B, Wang Y., 2015
- Oligomer-dependent and -independent chaperone activity of sHsps in different stressed conditions., Liu L, Chen J, Yang B, Wang Y., 2015
- ANT2 functions as a translocon for mitochondrial cross-membrane translocation of RNAs., Wang P, Zhang L, Chen S, Li R, Liu P, Li X, Luo H, Huo Y, Zhang Z, Cai Y, Liu X, Huang J, Zhou G, Sun Z, Ding S, Shi J, Zhou Z, Yuan R, Liu L, Wu S, Wang G., 2024
- Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States., Sun W, Yang J, Cheng Z, Amrani N, Liu C, Wang K, Ibraheim R, Edraki A, Huang X, Wang M, Wang J, Liu L, Sheng G, Yang Y, Lou J, Sontheimer EJ, Wang Y., 2019
- Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference., You L, Ma J, Wang J, Artamonva D, Wang M, Liu L, Xiang X, Severinov K, Zhang X, Wang Y., 2019
- A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment., Zhao X, Liu L, Lang J, Cheng K, Wang Y, Li X, Shi J, Wang Y, Nie G., 2018
- Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase., Chen JY, Liu L, Cao CL, Li MJ, Tan K, Yang X, Yun CH., 2016
Awards
- 2018 - Second Prize of Beijing Science and Technology Award
