Professor | Liang Liu | Asia Growth Partners

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Name	Liang Liu
Contact Information	liangliu2019@xmu.edu.cn
Language ability	Chinese, English
Province	Fujian

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Name

Liang Liu

Contact Information

liangliu2019@xmu.edu.cn

Language ability

Chinese, English

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	2010 - B.S. in Bioengineering: South-central University For Nationalities 2015 - Ph.D. in Biochemical Engineering: South China University of Technology 2018 - Selected for the 4th China Association for Science and Technology Youth Talent Support Project 2019 - Selected as Xiamen University Nanqiang Young Top Talent A Class 2021 - Received National Excellent Young Scientists Fund 2024 - Received Fujian Province Qing Project Support
Work Experience	2012-2015 - Visiting Scholar: Peking University 2015-2019 - Postdoctoral Fellow/Associate Professor: Chinese Academy of Sciences 2019-Present - Professor: School of Life Sciences, Xiamen University
Awards	2018 - Second Prize of Beijing Science and Technology Award

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

2010 - B.S. in Bioengineering: South-central University For Nationalities
2015 - Ph.D. in Biochemical Engineering: South China University of Technology
2018 - Selected for the 4th China Association for Science and Technology Youth Talent Support Project
2019 - Selected as Xiamen University Nanqiang Young Top Talent A Class
2021 - Received National Excellent Young Scientists Fund
2024 - Received Fujian Province Qing Project Support

Work Experience

2012-2015 - Visiting Scholar: Peking University
2015-2019 - Postdoctoral Fellow/Associate Professor: Chinese Academy of Sciences
2019-Present - Professor: School of Life Sciences, Xiamen University

Awards

2018 - Second Prize of Beijing Science and Technology Award

Areas of Focus	Development and application of gene editing and molecular diagnostic tools Molecular mechanisms of prokaryotic defense systems and viral antagonism of host immunity Nucleic acid processing and modification Structural biology research on RNA-mediated gene expression and regulation
Publications	Trans-nuclease activity of Cas9 activated by DNA or RNA target binding., Chen J, Chen Y, Huang L, Lin X, Chen H, Xiang W, Liu L., 2024 Structural and mechanistic insight into ribosomal ITS2 RNA processing by nuclease-kinase machinery., Chen J, Chen H, Li S, Lin X, Hu R, Zhang K, Liu L., 2024 Structural basis for MTA1c-mediated DNA N6-adenine methylation., Chen J, Hu R, Chen Y, Lin X, Xiang W, Chen H, Yao C, Liu L., 2022 Phage AcrⅡA2 DNA Mimicry: Structural Basis of the CRISPR/anti-CRISPR Arms Race., Liu L, Yin M, Wang M, Wang Y., 2019 The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a., Liu L, Li X, Ma J, Li Z, You L, Wang J, Wang M, Zhang X, Wang Y., 2017 Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities., Liu L, Li X, Wang J, Yin M, Chen P, Wang M, Li J, Sheng G, Wang Y., 2017 C2c1-sgRNA Complex Structure Reveals RNA-guided DNA Cleavage Mechanism., Liu L, Chen P, Wang M, Li X, Wang J, Yin M, Wang Y., 2017 Active-State Structures of a Small Heat-Shock Protein Revealed a Molecular Switch for Chaperone Function., Liu L, Chen JY, Yang B, Wang FH, Wang YH, Yun CH., 2015 Crystal structure and function of an unusual dimeric Hsp20.1 provide insight into the thermal protection mechanism of small heat shock proteins., Liu L, Chen J, Yang B, Wang Y., 2015 Oligomer-dependent and -independent chaperone activity of sHsps in different stressed conditions., Liu L, Chen J, Yang B, Wang Y., 2015 ANT2 functions as a translocon for mitochondrial cross-membrane translocation of RNAs., Wang P, Zhang L, Chen S, Li R, Liu P, Li X, Luo H, Huo Y, Zhang Z, Cai Y, Liu X, Huang J, Zhou G, Sun Z, Ding S, Shi J, Zhou Z, Yuan R, Liu L, Wu S, Wang G., 2024 Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States., Sun W, Yang J, Cheng Z, Amrani N, Liu C, Wang K, Ibraheim R, Edraki A, Huang X, Wang M, Wang J, Liu L, Sheng G, Yang Y, Lou J, Sontheimer EJ, Wang Y., 2019 Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference., You L, Ma J, Wang J, Artamonva D, Wang M, Liu L, Xiang X, Severinov K, Zhang X, Wang Y., 2019 A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment., Zhao X, Liu L, Lang J, Cheng K, Wang Y, Li X, Shi J, Wang Y, Nie G., 2018 Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase., Chen JY, Liu L, Cao CL, Li MJ, Tan K, Yang X, Yun CH., 2016

Areas of Focus

Development and application of gene editing and molecular diagnostic tools
Molecular mechanisms of prokaryotic defense systems and viral antagonism of host immunity
Nucleic acid processing and modification
Structural biology research on RNA-mediated gene expression and regulation

Publications

Trans-nuclease activity of Cas9 activated by DNA or RNA target binding., Chen J, Chen Y, Huang L, Lin X, Chen H, Xiang W, Liu L., 2024
Structural and mechanistic insight into ribosomal ITS2 RNA processing by nuclease-kinase machinery., Chen J, Chen H, Li S, Lin X, Hu R, Zhang K, Liu L., 2024
Structural basis for MTA1c-mediated DNA N6-adenine methylation., Chen J, Hu R, Chen Y, Lin X, Xiang W, Chen H, Yao C, Liu L., 2022
Phage AcrⅡA2 DNA Mimicry: Structural Basis of the CRISPR/anti-CRISPR Arms Race., Liu L, Yin M, Wang M, Wang Y., 2019
The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a., Liu L, Li X, Ma J, Li Z, You L, Wang J, Wang M, Zhang X, Wang Y., 2017
Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities., Liu L, Li X, Wang J, Yin M, Chen P, Wang M, Li J, Sheng G, Wang Y., 2017
C2c1-sgRNA Complex Structure Reveals RNA-guided DNA Cleavage Mechanism., Liu L, Chen P, Wang M, Li X, Wang J, Yin M, Wang Y., 2017
Active-State Structures of a Small Heat-Shock Protein Revealed a Molecular Switch for Chaperone Function., Liu L, Chen JY, Yang B, Wang FH, Wang YH, Yun CH., 2015
Crystal structure and function of an unusual dimeric Hsp20.1 provide insight into the thermal protection mechanism of small heat shock proteins., Liu L, Chen J, Yang B, Wang Y., 2015
Oligomer-dependent and -independent chaperone activity of sHsps in different stressed conditions., Liu L, Chen J, Yang B, Wang Y., 2015
ANT2 functions as a translocon for mitochondrial cross-membrane translocation of RNAs., Wang P, Zhang L, Chen S, Li R, Liu P, Li X, Luo H, Huo Y, Zhang Z, Cai Y, Liu X, Huang J, Zhou G, Sun Z, Ding S, Shi J, Zhou Z, Yuan R, Liu L, Wu S, Wang G., 2024
Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States., Sun W, Yang J, Cheng Z, Amrani N, Liu C, Wang K, Ibraheim R, Edraki A, Huang X, Wang M, Wang J, Liu L, Sheng G, Yang Y, Lou J, Sontheimer EJ, Wang Y., 2019
Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference., You L, Ma J, Wang J, Artamonva D, Wang M, Liu L, Xiang X, Severinov K, Zhang X, Wang Y., 2019
A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment., Zhao X, Liu L, Lang J, Cheng K, Wang Y, Li X, Shi J, Wang Y, Nie G., 2018
Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase., Chen JY, Liu L, Cao CL, Li MJ, Tan K, Yang X, Yun CH., 2016

Gene Editing Molecular Diagnostics Prokaryotic Defense Viral Immunity Nucleic Acid Rna Structural Biology Crispr Cas9 Biochemical Engineering

Wen Sheng Wei - Peking University

Luo Xin - University of Chinese Academy of Sciences

Guohui Chuai - Tongji University

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