Professor | Lanfen Chen | Asia Growth Partners

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Name	Lanfen Chen
Contact Information	chenlanfen@xmu.edu.cn
Language ability	English, Chinese
Province	Fujian

Upload Avatar (500 x 500)

Name

Lanfen Chen

Contact Information

chenlanfen@xmu.edu.cn

Language ability

English, Chinese

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	1997 - B.S. Biology: Xiamen University 2000 - M.S. Biology: Xiamen University 2006 - Ph.D. Pathology: Yeshiva University 2019 - Received National Outstanding Youth Science Fund
Work Experience	2007-2012 - Harvard Medical School - Postdoctoral Fellow 2012-2013 - Xiamen University, School of Life Sciences - Associate Professor 2013-Now - Xiamen University, School of Life Sciences - Professor
Awards	2021 - 17th China Young Female Scientist Award 2020 - Fujian Province Natural Science First Prize 2019 - National Outstanding Youth Science Fund 2015 - Minjiang Scholar Award Program (Distinguished Professor) 2014 - National Excellent Youth Science Fund 2014 - National High-Level Youth Talent

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

1997 - B.S. Biology: Xiamen University
2000 - M.S. Biology: Xiamen University
2006 - Ph.D. Pathology: Yeshiva University
2019 - Received National Outstanding Youth Science Fund

Work Experience

2007-2012 - Harvard Medical School - Postdoctoral Fellow
2012-2013 - Xiamen University, School of Life Sciences - Associate Professor
2013-Now - Xiamen University, School of Life Sciences - Professor

Awards

2021 - 17th China Young Female Scientist Award
2020 - Fujian Province Natural Science First Prize
2019 - National Outstanding Youth Science Fund
2015 - Minjiang Scholar Award Program (Distinguished Professor)
2014 - National Excellent Youth Science Fund
2014 - National High-Level Youth Talent

Areas of Focus	T cell immune tolerance and autoimmune diseases Innate immune regulation and host anti-infection function Tumor immune regulation and microenvironment remodeling and intervention
Publications	Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor., Jinjia Zhang, Junhong Li, Yongqiang Hou, Yao Lin, Hao Zhao, Yiran Shi, Kaiyun Chen, Cheng Nian, Jiayu Tang, Lei Pan, Yunzhi Xing, Huan Gao, Bingying Yang, Zengfang Song, Yao Cheng, Yue Liu, Min Sun, Yueyue Linghu, Jiaxin Li, Haitao Huang, Zhangjian Lai, Zhien Zhou, Zifeng Li, Xiufeng Sun, Qinghua Chen, Dongxue Su, Wengang Li, Zhihai Peng, Pingguo Liu, Wei Chen, Hongling Huang, Yixin Chen, Bailong Xiao, Lilin Ye, Lanfen Chen, Dawang Zhou., 2024 SPTAN1/NUMB axis senses cell density to restrain cell growth and oncogenesis through Hippo signaling., Dongxue Su, Yuxi Li, Weiji Zhang, Huan Gao, Yao Cheng, Yongqiang Hou, Junhong Li, Yi Ye, Zhangjian Lai, Zhe Li, Haitao Huang, Jiaxin Li, Jinhuan Li, Mengyu Cheng, Cheng Nian, Na Wu, Zhien Zhou, Yunzhi Xing, He Liu, Jiayu Tang, Yu Zhao, Qinghua Chen, Lixin Hong, Wengang Li, Zhihai Peng, Bin Zhao, Randy L. Johnson, Pingguo Liu, Wanjin Hong, Lanfen Chen, Dawang Zhou., 2023 Glycogen accumulation and phase separation drives liver tumor initiation., Qingxu Liu, Jiaxin Li, Weiji Zhang, Chen Xiao, Shihao Zhang, Cheng Nian, Junhong Li, Dongxue Su, Lihong Chen, Qian Zhao, Hui Shao, Hao Zhao, Qinghua Chen, Yuxi Li, Jing Geng, Lixin Hong, Shuhai Lin, Qiao Wu, Xianming Deng, Rongqin Ke, Jin Ding, Randy L. Johnson, Xiaolong Liu, Lanfen Chen, Dawang Zhou., 2021 TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection., Jing Geng, Yiran Shi, Jinjia Zhang, Bingying Yang, Ping Wang, Weihong Yuan, Hao Zhao, Junhong Li, Funiu Qin, Lixin Hong, Changchuan Xie, Xianming Deng, Yujie Sun, Congying Wu, Lanfen Chen, Dawang Zhou., 2021 Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis., Ping Wang, Jing Geng, Jiahui Gao, Hao Zhao, Junhong Li, Yiran Shi, Bingying Yang, Chen Xiao, Yueyue Linghu, Xiufeng Sun, Xin Chen, Lixin Hong, Funiu Qin, Xun Li, Jau-Song Yu, Han You, Zengqiang Yuan, Dawang Zhou, Randy L. Johnson, Lanfen Chen., 2019 Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2., Shihao Zhang, Qinghua Chen, Qingxu Liu, Yuxi Li, Xiufeng Sun, Lixin Hong, Suyuan Ji, Chenyan Liu, Jing Geng, Weiji Zhang, Zhonglei Lu, Zhen-Yu Yin, Yuanyuan Zeng, Kwang-Huei Lin, Qiao Wu, Qiyuan Li, Keiko Nakayama, Keiich I Nakayama, Xianming Deng, Randy L. Johnson, Liang Zhu, Daming Gao, Lanfen Chen, Dawang Zhou., 2017 The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells., Jing Geng, Shujuan Yu, Hao Zhao, Xiufeng Sun, Xun Li, Ping Wang, Xiaolin Xiong, Lixin Hong, Changchuan Xie, Jiahui Gao, Yiran Shi, Jiaqi Peng, Randy L. Johnson, Nengming Xiao, Linrong Lu, Jiahuai Han, Dawang Zhou, Lanfen Chen., 2017 Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity., Jing Geng, Xiufeng Sun, Ping Wang, Shihao Zhang, Xiaozhen Wang, Hongtan Wu, Lixin Hong, Changchuan Xie, Xun Li, Hao Zhao, Qingxu Liu, Mingting Jiang, Qinghua Chen, Jinjia Zhang, Yang Li, Siyang Song, Hong-Rui Wang, Rongbin Zhou, Randy L. Johnson, Kun-Yi Chien, Sheng-Cai Lin, Jiahuai Han, Joseph Avruch, Lanfen Chen, Dawang Zhou., 2015 Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis., Hongtan Wu, Luyao Wei, Fuqin Fan, Suyuan Ji, Shihao Zhang, Jing Geng, Lixin Hong, Xin Fan, Qinghua Chen, Jing Tian, Mingting Jiang, Xiufeng Sun, Changnan Jin, Zhen-Yu Yin, Qingxu Liu, Jinjia Zhang, Funiu Qin, Kwang-Huei Lin, Jau-Song Yu, Xianming Deng, Hong-Rui Wang, Bin Zhao, Randy L. Johnson, Lanfen Chen, Dawang Zhou., 2015 The Ets Transcription Factor GABP Is a Component of the Hippo Pathway Essential for Growth and Antioxidant Defense., Hongtan Wu, Yubo Xiao, Shihao Zhang, Suyuan Ji, Luyao Wei, Fuqin Fan, Jing Geng, Jing Tian, Xiufeng Sun, Funiu Qin, Changnan Jin, Jianjun Lin, Zhen-Yu Yin, Ting Zhang, Lianzhong Luo, Yang Li, Siyang Song, Sheng-Cai Lin, Xianming Deng, Fernando Camargo, Joseph Avruch, Lanfen Chen, Dawang Zhou., 2013

Areas of Focus

T cell immune tolerance and autoimmune diseases
Innate immune regulation and host anti-infection function
Tumor immune regulation and microenvironment remodeling and intervention

Publications

Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor., Jinjia Zhang, Junhong Li, Yongqiang Hou, Yao Lin, Hao Zhao, Yiran Shi, Kaiyun Chen, Cheng Nian, Jiayu Tang, Lei Pan, Yunzhi Xing, Huan Gao, Bingying Yang, Zengfang Song, Yao Cheng, Yue Liu, Min Sun, Yueyue Linghu, Jiaxin Li, Haitao Huang, Zhangjian Lai, Zhien Zhou, Zifeng Li, Xiufeng Sun, Qinghua Chen, Dongxue Su, Wengang Li, Zhihai Peng, Pingguo Liu, Wei Chen, Hongling Huang, Yixin Chen, Bailong Xiao, Lilin Ye, Lanfen Chen, Dawang Zhou., 2024
SPTAN1/NUMB axis senses cell density to restrain cell growth and oncogenesis through Hippo signaling., Dongxue Su, Yuxi Li, Weiji Zhang, Huan Gao, Yao Cheng, Yongqiang Hou, Junhong Li, Yi Ye, Zhangjian Lai, Zhe Li, Haitao Huang, Jiaxin Li, Jinhuan Li, Mengyu Cheng, Cheng Nian, Na Wu, Zhien Zhou, Yunzhi Xing, He Liu, Jiayu Tang, Yu Zhao, Qinghua Chen, Lixin Hong, Wengang Li, Zhihai Peng, Bin Zhao, Randy L. Johnson, Pingguo Liu, Wanjin Hong, Lanfen Chen, Dawang Zhou., 2023
Glycogen accumulation and phase separation drives liver tumor initiation., Qingxu Liu, Jiaxin Li, Weiji Zhang, Chen Xiao, Shihao Zhang, Cheng Nian, Junhong Li, Dongxue Su, Lihong Chen, Qian Zhao, Hui Shao, Hao Zhao, Qinghua Chen, Yuxi Li, Jing Geng, Lixin Hong, Shuhai Lin, Qiao Wu, Xianming Deng, Rongqin Ke, Jin Ding, Randy L. Johnson, Xiaolong Liu, Lanfen Chen, Dawang Zhou., 2021
TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection., Jing Geng, Yiran Shi, Jinjia Zhang, Bingying Yang, Ping Wang, Weihong Yuan, Hao Zhao, Junhong Li, Funiu Qin, Lixin Hong, Changchuan Xie, Xianming Deng, Yujie Sun, Congying Wu, Lanfen Chen, Dawang Zhou., 2021
Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis., Ping Wang, Jing Geng, Jiahui Gao, Hao Zhao, Junhong Li, Yiran Shi, Bingying Yang, Chen Xiao, Yueyue Linghu, Xiufeng Sun, Xin Chen, Lixin Hong, Funiu Qin, Xun Li, Jau-Song Yu, Han You, Zengqiang Yuan, Dawang Zhou, Randy L. Johnson, Lanfen Chen., 2019
Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2., Shihao Zhang, Qinghua Chen, Qingxu Liu, Yuxi Li, Xiufeng Sun, Lixin Hong, Suyuan Ji, Chenyan Liu, Jing Geng, Weiji Zhang, Zhonglei Lu, Zhen-Yu Yin, Yuanyuan Zeng, Kwang-Huei Lin, Qiao Wu, Qiyuan Li, Keiko Nakayama, Keiich I Nakayama, Xianming Deng, Randy L. Johnson, Liang Zhu, Daming Gao, Lanfen Chen, Dawang Zhou., 2017
The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells., Jing Geng, Shujuan Yu, Hao Zhao, Xiufeng Sun, Xun Li, Ping Wang, Xiaolin Xiong, Lixin Hong, Changchuan Xie, Jiahui Gao, Yiran Shi, Jiaqi Peng, Randy L. Johnson, Nengming Xiao, Linrong Lu, Jiahuai Han, Dawang Zhou, Lanfen Chen., 2017
Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity., Jing Geng, Xiufeng Sun, Ping Wang, Shihao Zhang, Xiaozhen Wang, Hongtan Wu, Lixin Hong, Changchuan Xie, Xun Li, Hao Zhao, Qingxu Liu, Mingting Jiang, Qinghua Chen, Jinjia Zhang, Yang Li, Siyang Song, Hong-Rui Wang, Rongbin Zhou, Randy L. Johnson, Kun-Yi Chien, Sheng-Cai Lin, Jiahuai Han, Joseph Avruch, Lanfen Chen, Dawang Zhou., 2015
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis., Hongtan Wu, Luyao Wei, Fuqin Fan, Suyuan Ji, Shihao Zhang, Jing Geng, Lixin Hong, Xin Fan, Qinghua Chen, Jing Tian, Mingting Jiang, Xiufeng Sun, Changnan Jin, Zhen-Yu Yin, Qingxu Liu, Jinjia Zhang, Funiu Qin, Kwang-Huei Lin, Jau-Song Yu, Xianming Deng, Hong-Rui Wang, Bin Zhao, Randy L. Johnson, Lanfen Chen, Dawang Zhou., 2015
The Ets Transcription Factor GABP Is a Component of the Hippo Pathway Essential for Growth and Antioxidant Defense., Hongtan Wu, Yubo Xiao, Shihao Zhang, Suyuan Ji, Luyao Wei, Fuqin Fan, Jing Geng, Jing Tian, Xiufeng Sun, Funiu Qin, Changnan Jin, Jianjun Lin, Zhen-Yu Yin, Ting Zhang, Lianzhong Luo, Yang Li, Siyang Song, Sheng-Cai Lin, Xianming Deng, Fernando Camargo, Joseph Avruch, Lanfen Chen, Dawang Zhou., 2013

T Cells Immune Tolerance Autoimmune Diseases Innate Immunity Host Defense Infection Tumor Immunity Microenvironment Remodeling Intervention

Wen Zheng Jiang - East China Normal University

Jun Cui - Sun Yat-Sen University

Nengming Xiao - Xiamen University

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