Professor | Xianming Deng | Asia Growth Partners

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Name	Xianming Deng
Contact Information	xmdeng@xmu.edu.cn
Language ability	English, Chinese
Province	Fujian

Upload Avatar (500 x 500)

Name

Xianming Deng

Contact Information

xmdeng@xmu.edu.cn

Language ability

English, Chinese

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	2001 - Bachelor's Degree in Chemistry: Xiamen University 2006 - Ph.D. in Organic Chemistry: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 2020 - Received National Science Fund for Distinguished Young Scholars
Work Experience	2006-2011 - Research Fellow: Dana-Farber Cancer Institute, Harvard Medical School 2011-Present - Principal Investigator: School of Life Sciences, Xiamen University
Awards	2017 - Fujian Province 14th Youth Science and Technology Award 2018 - WuXi AppTec Life Chemistry Research Award 2019 - Xiamen University Tian Zhaowu Interdisciplinary Award Special Prize 2019 - Fujian Province Natural Science Award First Prize (Third Contributor) 2023 - New Cornerstone Science Foundation Science Exploration Award

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

2001 - Bachelor's Degree in Chemistry: Xiamen University
2006 - Ph.D. in Organic Chemistry: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
2020 - Received National Science Fund for Distinguished Young Scholars

Work Experience

2006-2011 - Research Fellow: Dana-Farber Cancer Institute, Harvard Medical School
2011-Present - Principal Investigator: School of Life Sciences, Xiamen University

Awards

2017 - Fujian Province 14th Youth Science and Technology Award
2018 - WuXi AppTec Life Chemistry Research Award
2019 - Xiamen University Tian Zhaowu Interdisciplinary Award Special Prize
2019 - Fujian Province Natural Science Award First Prize (Third Contributor)
2023 - New Cornerstone Science Foundation Science Exploration Award

Areas of Focus	Chemical Biology Medicinal Chemistry
Publications	Low-dose metformin targets the lysosomal AMPK pathway through PEN2., Ma, T.; Tian, X.; Zhang, B.; Li, M.; Wang, Y.; Yang, C.; Wu, J.; Wei, X.; Qu, Q.; Yu, Y.; Long, S.; Feng, J.-W.; Li, C.; Zhang, C.; Xie, C.; Wu, Y.; Xu, Z.; Chen, J.; Yu, Y.; Huang, X.; He, Y.; Yao, L.; Zhang, L.; Zhu, M.; Wang, W.; Wang, Z.-C.; Zhang, M.; Bao, Y.; Jia, W.; Lin, S.-Y.; Ye, Z.; Piao, H.-L.; Deng, X.; Zhang, C.-S.; Lin, S.-C., 2022 Pharmacological targeting of STK19 inhibits oncogenic NRAS driven melanomagenesis., Yin, C.; Zhu, B.; Zhang, T.; Liu, T.; Chen, S.; Liu, Y.; Li, X.; Miao, X.; Li, S.; Mi, X.; Zhang, J.; Li, L.; Wei, G.; Xu, Z.; Gao, X.; Huang, C.; Wei, Z.; Goding, C. R.; Wang, P.; Deng, X.; Cui, R., 2019 Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration., Fan, F.; He, Z.; Kong, L. L.; Chen, Q.; Yuan, Q.; Zhang, S.; Ye, J.; Liu, H.; Sun, X.; Geng, J.; Yuan, L.; Hong, L.; Xiao, C.; Zhang, W.; Li, Y.; Wang, P.; Huang, L.; Wu, X.; Ji, Z.; Wu, Q.; Xia, N. S.; Gray, N. S.; Chen, L.; Yun, C. H.; Deng, X.; Zhou, D., 2016 A new ALK inhibitor overcomes resistance to first- and second-generation inhibitors in NSCLC., Lu, Y.; Fan, Z.; Zhu, S. J.; Huang, X.; Zhuang, Z.; Li, Y.; Deng, Z.; Gao, L.; Hong, X.; Zhang, T.; Li, L.; Sun, X.; Huang, W.; Zhang, J.; Liu, Y.; Zhang, B.; Jiang, J.; Gui, F.; Wang, Z.; Li, Q.; Song, S.; Huang, X.; Wu, Q.; Chen, L.; Zhou, D.; Zhang, J.; Yun, C. H.; Chen, L.; Deng, X., 2022 Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a., Zhang, J.; Bhuiyan, M. I. H.; Zhang, T.; Karimy, J. K.; Wu, Z.; Fiesler, V. M.; Zhang, J.; Huang, H.; Hasan, M. N.; Skrzypiec, A. E.; Mucha, M.; Duran, D.; Huang, W.; Pawlak, R.; Foley, L. M.; Hitchens, T. K.; Minnigh, M. B.; Poloyac, S. M.; Alper, S. L.; Molyneaux, B. J.; Trevelyan, A. J.; Kahle, K. T.; Sun, D.; Deng, X., 2020 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer., Wang, Y.; Zhang, L.; Wei, Y.; Huang, W.; Li, L.; Wu, A. A.; Dastur, A.; Greninger, P.; Bray, W. M.; Zhang, C. S.; Li, M.; Lian, W.; Hu, Z.; Wang, X.; Liu, G.; Yao, L.; Guh, J. H.; Chen, L.; Wang, H. R.; Zhou, D.; Lin, S. C.; Xu, Q.; Shen, Y.; Zhang, J.; Jurica, M. S.; Benes, C. H.; Deng, X., 2020 Tandem-Mass-Tag Based Proteomic Analysis Facilitates Analyzing Critical Factors of Porous Silicon Nanoparticles in Determining Their Biological Responses under Diseased Condition., Li, Y.; Liu, Z.; Li, L.; Lian, W.; He, Y.; Khalil, E.; Mäkilä, E.; Zhang, W.; Torrieri, G.; Liu, X.; Su, J.; Xiu, Y.; Fontana, F.; Salonen, J.; Hirvonen, J.; Liu, W.; Zhang, H.; Santos, H. A.; Deng, X., 2020 Biosynthesis and Chemical Diversification of Verucopeptin Leads to Structural and Functional Versatility., Zhang, L.; Wang, Y.; Huang, W.; Wei, Y.; Jiang, Z.; Kong, L.; Wu, A. A.; Hu, Z.; Huang, H.; Xu, Q.; Li, L.; Deng, X., 2020 A non-covalent inhibitor XMU-MP-3 overrides ibrutinib-resistant Btk(C481S) mutation in B-cell malignancies., Gui, F.; Jiang, J.; He, Z.; Li, L.; Li, Y.; Deng, Z.; Lu, Y.; Wu, X.; Chen, G.; Su, J.; Song, S.; Zhang, Y. M.; Yun, C. H.; Huang, X.; Weisberg, E.; Zhang, J.; Deng, X., 2019 A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases., Tian, M.; Zeng, T.; Liu, M.; Han, S.; Lin, H.; Lin, Q.; Li, L.; Jiang, T.; Li, G.; Zhang, T.; Kang, Q.; Deng, X.; Wang, H. R., 2019 Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing., Liu, Z.; Li, Y.; Li, W.; Lian, W.; Kemell, M.; Hietala, S.; Figueiredo, P.; Li, L.; Mäkilä, E.; Ma, M.; Salonen, J.; Hirvonen, J. T.; Liu, D.; Zhang, H.; Deng, X.; Santos, H. A., 2019 Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities., Huang, W.; Sun, X.; Li, Y.; He, Z.; Li, L.; Deng, Z.; Huang, X.; Han, S.; Zhang, T.; Zhong, J.; Wang, Z.; Xu, Q.; Zhang, J.; Deng, X., 2018 Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles, and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics., Liu, Z.; Li, Y.; Li, W.; Xiao, C.; Liu, D.; Dong, C.; Zhang, M.; Mäkilä, E.; Kemell, M.; Salonen, J.; Hirvonen, J. T.; Zhang, H.; Zhou, D.; Deng, X.; Santos, H. A., 2018 A Novel Microtubule Inhibitor Overcomes Multidrug Resistance in Tumors., Ning, N.; Yu, Y.; Wu, M.; Zhang, R.; Zhang, T.; Zhu, C.; Huang, L.; Yun, C. H.; Benes, C. H.; Zhang, J.; Deng, X.; Chen, Q.; Ren, R., 2018 Targeting BRK-positive breast cancers with small molecule kinase inhibitors., Jiang, J.; Gui, F.; He, Z.; Li, L.; Li, Y.; Li, S.; Wu, X.; Deng, Z.; Sun, X.; Huang, X.; Huang, W.; Han, S.; Zhang, T.; Wang, Z.; Jiao, B.; Song, S.; Wang, H.-R.; Chen, L.; Zhou, D.; Liu, Q.; Ren, R.; Zhang, J.; Deng, X., 2017 Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders., Jiang, H.; He, H.; Chen, Y.; Huang, W.; Cheng, J.; Ye, J.; Wang, A.; Tao, J.; Wang, C.; Liu, Q.; Jin, T.; Jiang, W.; Deng, X.; Zhou, R., 2017 Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity., He, H.; Jiang, H.; Chen, Y.; Ye, J.; Wang, A.; Wang, C.; Liu, Q.; Liang, G.; Deng, X.; Jiang, W.; Zhou, R., 2018 Aspertetranones A-D, Meroterpenoids from the Marine Algal-associated Fungus Aspergillus sp., Wang, Y.; Qi, S.; Zhan, Y.; Zhang, N.; Wu, A.; Gui, F.; Guo, K.; Yang, Y.; Hu, Z.; Zheng, Z.; Song, S.; Xu, Q.; Shen, Y.; Deng, X., 2015 Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2., Deng, X.; Dzamko, N.; Prescott, A.; Davies, P.; Liu, Q.; Yang, Q.; Lee, J. D.; Patricelli, M. P.; Nomanbhoy, T. K.; Alessi, D. R.; Gray, N. S., 2011 Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein., Yang, Q.; Deng, X.; Lu, B.; Cameron, M.; Fearns, C.; Patricelli, M. P.; Yates, J. R., 3rd; Gray, N. S.; Lee, J. D., 2010

Areas of Focus

Chemical Biology
Medicinal Chemistry

Publications

Low-dose metformin targets the lysosomal AMPK pathway through PEN2., Ma, T.; Tian, X.; Zhang, B.; Li, M.; Wang, Y.; Yang, C.; Wu, J.; Wei, X.; Qu, Q.; Yu, Y.; Long, S.; Feng, J.-W.; Li, C.; Zhang, C.; Xie, C.; Wu, Y.; Xu, Z.; Chen, J.; Yu, Y.; Huang, X.; He, Y.; Yao, L.; Zhang, L.; Zhu, M.; Wang, W.; Wang, Z.-C.; Zhang, M.; Bao, Y.; Jia, W.; Lin, S.-Y.; Ye, Z.; Piao, H.-L.; Deng, X.; Zhang, C.-S.; Lin, S.-C., 2022
Pharmacological targeting of STK19 inhibits oncogenic NRAS driven melanomagenesis., Yin, C.; Zhu, B.; Zhang, T.; Liu, T.; Chen, S.; Liu, Y.; Li, X.; Miao, X.; Li, S.; Mi, X.; Zhang, J.; Li, L.; Wei, G.; Xu, Z.; Gao, X.; Huang, C.; Wei, Z.; Goding, C. R.; Wang, P.; Deng, X.; Cui, R., 2019
Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration., Fan, F.; He, Z.; Kong, L. L.; Chen, Q.; Yuan, Q.; Zhang, S.; Ye, J.; Liu, H.; Sun, X.; Geng, J.; Yuan, L.; Hong, L.; Xiao, C.; Zhang, W.; Li, Y.; Wang, P.; Huang, L.; Wu, X.; Ji, Z.; Wu, Q.; Xia, N. S.; Gray, N. S.; Chen, L.; Yun, C. H.; Deng, X.; Zhou, D., 2016
A new ALK inhibitor overcomes resistance to first- and second-generation inhibitors in NSCLC., Lu, Y.; Fan, Z.; Zhu, S. J.; Huang, X.; Zhuang, Z.; Li, Y.; Deng, Z.; Gao, L.; Hong, X.; Zhang, T.; Li, L.; Sun, X.; Huang, W.; Zhang, J.; Liu, Y.; Zhang, B.; Jiang, J.; Gui, F.; Wang, Z.; Li, Q.; Song, S.; Huang, X.; Wu, Q.; Chen, L.; Zhou, D.; Zhang, J.; Yun, C. H.; Chen, L.; Deng, X., 2022
Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a., Zhang, J.; Bhuiyan, M. I. H.; Zhang, T.; Karimy, J. K.; Wu, Z.; Fiesler, V. M.; Zhang, J.; Huang, H.; Hasan, M. N.; Skrzypiec, A. E.; Mucha, M.; Duran, D.; Huang, W.; Pawlak, R.; Foley, L. M.; Hitchens, T. K.; Minnigh, M. B.; Poloyac, S. M.; Alper, S. L.; Molyneaux, B. J.; Trevelyan, A. J.; Kahle, K. T.; Sun, D.; Deng, X., 2020
Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer., Wang, Y.; Zhang, L.; Wei, Y.; Huang, W.; Li, L.; Wu, A. A.; Dastur, A.; Greninger, P.; Bray, W. M.; Zhang, C. S.; Li, M.; Lian, W.; Hu, Z.; Wang, X.; Liu, G.; Yao, L.; Guh, J. H.; Chen, L.; Wang, H. R.; Zhou, D.; Lin, S. C.; Xu, Q.; Shen, Y.; Zhang, J.; Jurica, M. S.; Benes, C. H.; Deng, X., 2020
Tandem-Mass-Tag Based Proteomic Analysis Facilitates Analyzing Critical Factors of Porous Silicon Nanoparticles in Determining Their Biological Responses under Diseased Condition., Li, Y.; Liu, Z.; Li, L.; Lian, W.; He, Y.; Khalil, E.; Mäkilä, E.; Zhang, W.; Torrieri, G.; Liu, X.; Su, J.; Xiu, Y.; Fontana, F.; Salonen, J.; Hirvonen, J.; Liu, W.; Zhang, H.; Santos, H. A.; Deng, X., 2020
Biosynthesis and Chemical Diversification of Verucopeptin Leads to Structural and Functional Versatility., Zhang, L.; Wang, Y.; Huang, W.; Wei, Y.; Jiang, Z.; Kong, L.; Wu, A. A.; Hu, Z.; Huang, H.; Xu, Q.; Li, L.; Deng, X., 2020
A non-covalent inhibitor XMU-MP-3 overrides ibrutinib-resistant Btk(C481S) mutation in B-cell malignancies., Gui, F.; Jiang, J.; He, Z.; Li, L.; Li, Y.; Deng, Z.; Lu, Y.; Wu, X.; Chen, G.; Su, J.; Song, S.; Zhang, Y. M.; Yun, C. H.; Huang, X.; Weisberg, E.; Zhang, J.; Deng, X., 2019
A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases., Tian, M.; Zeng, T.; Liu, M.; Han, S.; Lin, H.; Lin, Q.; Li, L.; Jiang, T.; Li, G.; Zhang, T.; Kang, Q.; Deng, X.; Wang, H. R., 2019
Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing., Liu, Z.; Li, Y.; Li, W.; Lian, W.; Kemell, M.; Hietala, S.; Figueiredo, P.; Li, L.; Mäkilä, E.; Ma, M.; Salonen, J.; Hirvonen, J. T.; Liu, D.; Zhang, H.; Deng, X.; Santos, H. A., 2019
Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities., Huang, W.; Sun, X.; Li, Y.; He, Z.; Li, L.; Deng, Z.; Huang, X.; Han, S.; Zhang, T.; Zhong, J.; Wang, Z.; Xu, Q.; Zhang, J.; Deng, X., 2018
Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles, and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics., Liu, Z.; Li, Y.; Li, W.; Xiao, C.; Liu, D.; Dong, C.; Zhang, M.; Mäkilä, E.; Kemell, M.; Salonen, J.; Hirvonen, J. T.; Zhang, H.; Zhou, D.; Deng, X.; Santos, H. A., 2018
A Novel Microtubule Inhibitor Overcomes Multidrug Resistance in Tumors., Ning, N.; Yu, Y.; Wu, M.; Zhang, R.; Zhang, T.; Zhu, C.; Huang, L.; Yun, C. H.; Benes, C. H.; Zhang, J.; Deng, X.; Chen, Q.; Ren, R., 2018
Targeting BRK-positive breast cancers with small molecule kinase inhibitors., Jiang, J.; Gui, F.; He, Z.; Li, L.; Li, Y.; Li, S.; Wu, X.; Deng, Z.; Sun, X.; Huang, X.; Huang, W.; Han, S.; Zhang, T.; Wang, Z.; Jiao, B.; Song, S.; Wang, H.-R.; Chen, L.; Zhou, D.; Liu, Q.; Ren, R.; Zhang, J.; Deng, X., 2017
Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders., Jiang, H.; He, H.; Chen, Y.; Huang, W.; Cheng, J.; Ye, J.; Wang, A.; Tao, J.; Wang, C.; Liu, Q.; Jin, T.; Jiang, W.; Deng, X.; Zhou, R., 2017
Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity., He, H.; Jiang, H.; Chen, Y.; Ye, J.; Wang, A.; Wang, C.; Liu, Q.; Liang, G.; Deng, X.; Jiang, W.; Zhou, R., 2018
Aspertetranones A-D, Meroterpenoids from the Marine Algal-associated Fungus Aspergillus sp., Wang, Y.; Qi, S.; Zhan, Y.; Zhang, N.; Wu, A.; Gui, F.; Guo, K.; Yang, Y.; Hu, Z.; Zheng, Z.; Song, S.; Xu, Q.; Shen, Y.; Deng, X., 2015
Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2., Deng, X.; Dzamko, N.; Prescott, A.; Davies, P.; Liu, Q.; Yang, Q.; Lee, J. D.; Patricelli, M. P.; Nomanbhoy, T. K.; Alessi, D. R.; Gray, N. S., 2011
Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein., Yang, Q.; Deng, X.; Lu, B.; Cameron, M.; Fearns, C.; Patricelli, M. P.; Yates, J. R., 3rd; Gray, N. S.; Lee, J. D., 2010

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