2003 - Ph.D. in Biochemistry & Molecular Biology/Zoology: Xiamen University
2003 to Present - Xiamen University, School of Life Sciences - Lecturer/Associate Professor/Professor
2020: National Hundred, Thousand and Ten Thousand Talent Project 'Outstanding Young and Middle-aged Expert with Outstanding Contributions'
2020: Member of WHO Vaccine Product Development Advisory Committee
2020: Host of National Natural Science Foundation, '863' Project, Major New Drug Creation Project and Rolling Projects
2020: China Association for Science and Technology Qiu Shi Outstanding Youth Achievement Transformation Award
2019: 'Xiamen Top Talent'
2018: China Patent Gold Award and the 10th Zijin Technology Innovation Award
2017: Selected as one of the Global Top 20 Translational Researchers by Nature Biotechnology
2017: Developed hepatitis E vaccine, cervical cancer vaccine, condyloma acuminatum vaccine, hepatitis E diagnostic reagent, AIDS diagnostic reagent, and COVID-19 diagnostic reagent
2015: China Association for Science and Technology Qiu Shi Outstanding Young Scholar Award
2012: 14th China Patent Award - Gold Award
2011: Ministry of Education New Century Excellent Talent
2011: Fujian Province Outstanding Youth Fund
2001: National Science and Technology Progress Second Prize
2010: National Technology Invention Second Prize
2001: First Prize of Science and Technology Progress of Chinese Universities
Authorized 29 invention patents, 15 international authorizations
Research
Research and development of recombinant human vaccines Structural basis and functional implication for underlying immune epitopes of key infectious viruses Structure-based rational design for vaccine immunogens
Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209, Ju B#, Zheng Q#, Guo H#, Fan Q#, Li T#, Song S#, Sun H#, Shen S, Zhou X, Xue W, Cui L, Zhou B, Li S*, Xia N*, Zhang Z*, 2022
Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron, Wang S#, Sun H#, Zhang Y#, Yuan L#, Wang Y#, Zhang T#, Wang S, Zhang J, Yu H, Xiong H, Tang Z, Liu L, Huang Y, Chen X, Li T, Ying D, Liu C, Chen Z, Yuan Q, Zhang J*, Cheng T*, Li S*, Guan Y*, Zheng Q*, Zheng Z*, Xia N*, 2022
Structures of pseudorabies virus capsids, Wang G#, Zha Z#, Huang P#, Sun H#, Huang Y, He M, Chen T, Lin L, Chen Z, Kong Z, Que Y, Li T, Gu Y, Yu H, Zhang J, Zheng Q*, Chen Y*, Li S*, Xia N*, 2022
A Bacterially Expressed SARS-CoV-2 Receptor Binding Domain Fused With Cross-Reacting Material 197 A-Domain Elicits High Level of Neutralizing Antibodies in Mice, Liu L#, Chen T#, Zhou L, Sun J, Li Y, Nie M, Xiong H, Zhu Y, Xue W, Wu Y, Li T, Zhang T, Kong Z, Yu H, Zhang J, Gu Y, Zheng Q, Zhao Q*, Xia N, Li S*, 2022
A stepwise docking molecular dynamics approach for simulating antibody recognition with substantial conformational changes, Huang Y#, Li Z#, Hong Q, Zhou L, Ma Y, Hu Y, Xin J, Li T, Kong Z, Zheng Q, Chen Y, Zhao Q, Gu Y, Zhang J, Wang Y*, Yu H*, Li S*, Xia N, 2022
Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants, T Li#, W Xue#, Q Zheng#, S Song#, C Yang#, H Xiong#, S Zhang, M Hong, Y Zhang, H Yu, Y Zhang, H Sun, Y Huang, T Deng, X Chi, J Li, S Wang, L Zhou, T Chen, Y Wang, T Cheng, T Zhang, Q Yuan, Q Zhao, J Zhang, J. S. McLellan, Z Zhou*, Z Zhang*, S Li*, Y Gu*, N Xia*, 2021
Cryo-EM Structures Reveal Basis of Receptor-Initiated Coxsackievirus Uncoating with Implications for Therapeutic Antibody Development, L Xu#, Q Zheng#, R Zhu#, Z Yin#, H Yu#, Y Lin, Y Wu, M He, Y Huang, Y Jiang, H Sun, Z Zha, H Yang, Q Huang, D Zhang, Z Chen, X Ye, J Han, L Yang, C Liu, Y Que, M Fang, Y Gu, J Zhang, W Luo, Z Zhou*, S Li*, T Cheng*, N Xia*, 2021
Structural basis for the shared neutralization mechanism of three classes of human papillomavirus type 58 antibodies with disparate modes of binding, M He#, C Xin#, Z Zha#, Y Li, J Chen, Y Huang, S Huang, M Yu, Z Wang, S Song, X Liu, S Wei, Z Li, T Li, Y Wang, HYu, Q Zhao, J Zhang, Q Zheng*, Y Gu*, S Li*, N Xia*, 2021
Near-atomic cryo-electron microscopy structures of varicella-zoster virus capsids, W Wang#, Q Zheng#, D Pan#, H Yu#, W Fu, J Liu, M He, R Zhu, Y Cai, Y Huang, Z Zha, Z Chen, X Ye, J Han, Y Que, T Wu, J Zhang, S Li*, H Zhu*,Z Zhou*,T Cheng*and N Xia*, 2020
Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16, M He#, L Xu#, Q Zheng#, R Zhu#, Z Yin, Z Zha, Y Lin, L Yang, Y Huang, X Ye, S Li, W Hou, Y Wu, J Han, D Liu, Z Li, Z Chen, H Yu, Y Que, Y Wang, X Yan, J Zhang, Y Gu, Z Zhou*, T Cheng*, S Li*, N Xia*, 2020
Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles, D Wang#, X Liu#, M Wei#, C Qian, S Song, J Chen, Z Wang, Q Xu, Y Yang, M He, X Chi, S Huang, T Li, Z Kong, Q Zheng, H Yu, Y Wang, Q Zhao, J Zhang, N Xia*, Y Gu*& S Li*, 2020
SARS-CoV-2 spike produced in insect cells elicits high neutralization titres in non-human primates, T Li#, Q Zheng*#, H Yu, D Wu, W Xue, H Xiong, X Huang, M Nie, M Yue, R Rong, S Zhang, Y Zhang, Y Wu, S Wang, Z Zha, T Chen, T Deng, Y Wang, T Zhang, Y Chen, Q Yuan*, Q Zhao, J Zhang, Y Gu*, S Li*, N Xia*, 2020
Structural characterization of a neutralizing mAb H16.001 that is qualified to a common potency assay for various HPV16 vaccines, W Huang#, M He#, T Ning, J Nie, F Zhang, Q Zheng, R Zhang, Y Xu, Y Gu, S Li*, Y Wang*, 2020
Recent Progress on the Versatility of Virus-Like Particles, C Qian, X Liu, Q Xu, Z Wang, J Chen, T Li, Q Zheng, H Yu, Y Gu*, S Li*, N Xia*, 2020
Genome re-sequencing and reannotation of the Escherichia coli ER2566 strain and transcriptome sequencing under overexpression conditions, L Zhou#, H Yu#, K Wang#, T Chen, Y Ma, Y Huang, J Li, L Liu, Y Li, Z Kong, Q Zheng, Y Wang, Y Gu, N Xia, S Li*, 2020
Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization, Q Zheng#, R Zhu#, L Xu#, M He#, X Yan, D Liu, Z Yin, Y Wu, Y Li, L Yang, W Hou, S Li, Z Li, Z Chen, Z Li, H Yu, Y Gu, J Zhang, T. S. Baker, Z Zhou, B. S. Graham*, T Cheng*, S Li*, N Xia*, 2019
Viral neutralization by antibody-imposed physical disruption, Q Zheng#, J Jiang#, M He#, Z Zheng, H Yu, T Li, W Xue, Z Tang, D Ying, Z Li, S Song, X Liu, K Wang, Z Zhang, D Wang, Y Wang, X Yan, Q Zhao, J Zhang, Y Gu*, S Li*, N Xia*, 2019
Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection, X Liu#, J Chen#, Z Wang, D Wang, M He, C Qian, S Song, X Chi, Z Kong, Q Zheng, Y Wang, H Yu, Q Zhao, J Zhang, S Li*, Y Gu*, N Xia*, 2019
Construction of a bacterial surface display system based on outer membrane protein F, T Chen#, K Wang#, X Chi, L Zhou, J Li, L Liu, Q Zheng, Y Wang, H Yu, Y Gu, J Zhang, S Li*, N Xia*, 2019
Hepatitis E vaccine candidate harboring a non-particulate immunogen of E2 fused with CRM197 fragment A, K Wang#, L Zhou#, X Zhang, C Song, T Chen, J Li, M Zheng, Y Wang, Q Zheng, Z Zheng, H Yu, T Wu, Y Gu, J Zhang, Q Zhao*, S Li*, N Xia*, 2019
Characterization of native-like HIV-1 gp140 glycoprotein expressed in insect cells, T Li, Z Zhang, J Qiao, R Rong, Y Zhang, Q Yao, Z Li, H Shen, F Huang, W Xue, S Gao, S Li, Q Zheng, H Yu, J Zhang, Y Gu *, S Li*, N Xia, 2019
Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity, Z Li#, S Song#, M He#, D Wang, J Shi, X Liu, Y Li, X Chi, S Wei, Y Yang, Z Wang, J Li, H Qian, H Yu, Q Zheng, X Yan, Q Zhao, J Zhang, Y Gu*, S Li*, N Xia*, 2018
Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10, R Zhu#, L Xu#, Q Zheng#, Y Cui#, S Li#, M He, Z Yin, D Liu, S Li, Z Li, Z Chen, H Yu, Y Que , C Liu, Z Kong, J Zhang, T. S. Baker, X Yan*, Z Zhou*, T Cheng*, N Xia*, 2018
T = 4 Icosahedral HIV-1 Capsid As an Immunogenic Vector for HIV-1 V3 Loop Epitope Display, Z Zhang#, M He#, S Bai, F Zhang, J Jiang, Q Zheng, S Gao, X Yan, S Li*, Y Gu*, N Xia, 2018
N-terminal truncations on L1 proteins of human papillomaviruses promote their soluble expression in Escherichia coli and self-assembly in vitro, M Wei#, D Wang#, Z Li, S Song, X Kong, X Mo, Y Yang, M He, Z Li, B Huang, Z Lin, H Pan, Q Zheng, H Yu, Y Gu, J Zhang, S Li*, N Xia*, 2018
Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus, Q Lin#, T Li#, Y Chen#, S. Y. Lau, M Wei, Y Zhang, Z Zhang, Q Yao, J Li, Z Li, D Wang, Q Zheng, H Yu, Y Gu, J Zhang, H Chen, S Li*, N Xia*, 2018
Characterization of capsid protein (p495) of hepatitis E virus expressed ID in Escherichia coli and assembling into particles in vitro, M Zheng, J Jiang, X Zhang, N Wang, K Wang, Q Li, T Li, Q Lin, Y Wang, H Yu, Y Gu, J Zhang, S Li*, N Xia, 2018
Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus, Z Li#, D Wang#, Y Gu#, S Song, M He, J Shi, X Liu, S Wei, J Li, H Yu, Q Zheng, X Yan, T. S. Baker, J Zhang, J. S. McLellan*, S Li*, N Xia*, 2017
Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody, L Xu#, Q Zheng#, S Li#, M He#, Y Wu, Y Li, R Zhu, H Yu, Q Hong, J Jiang, Z Li, S Li, H Zhao, L Yang, W Hou, W Wang, X Ye, J Zhang, T. S. Baker, T Cheng *, Z Zhou, X Yan*, N Xia*, 2017
Bacterially expressed human papillomavirus type 6 and 11 bivalent vaccine: Characterization, antigenicity and immunogenicity, H Pan, Z Li, J Wang, S Song, D Wang, M Wei, Y Gu, J Zhang, S Li*, N Xia*, 2017
Characterization of an Escherichia coil-derived human papillomavirus type 16 and 18 bivalent vaccine, Y Gu, M Wei, D Wang, Z Li, M Xie, H Pan, T Wu, J Zhang, S Li*, N Xia*, 2017
Stop codon mutagenesis for homogenous expression of human papillomavirus L1 protein in Escherichia coli, D Wang#, F Fan#, Z Li, X Liu, S Song, S Wei, M He, Y Lin, Z Li, M Wei, H Yu, Y Gu, S Li*, N Xia, 2017
Characterization of an Escherichia coli-derived human papillomavirus type 16 and 18 bivalent vaccine, Gu Y, Wei M, Wang D, Li Z, Xie M, Pan H, Wu T, Zhang J, Li S*, Xia N*, 2017
The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction, Z Li#, X Yan#, H Yu#, D Wang, S Song, Y Li, M He, Q Hong, Q Zheng, Q Zhao, Y Gu, J Zhang, M. E. Janssen, G Cardone, N. H. Olson, T. S. Baker*, Li S*, Xia N, 2016
A shared N-terminal hydrophobic tail for the formation of nanoparticulates, X Zhang, K Wang, Q Lin, M Zheng, Q Li, T Li, Q Hong, Q Zheng, H Yu *, Y Gu, Li S*, Xia N*, 2016
Production of Influenza Virus HA1 Harboring Native-Like Epitopes by Pichia pastoris, Q Lin, K Yang, F He, J Jiang, T Li, Z Chen, R Li, Y Chen, Li S*, Q Zhao*, N Xia, 2016
Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody, Y Gu, X Tang, X Zhang, C Song, M Zheng, K Wang, J Zhang, M. H. Ng, C. L. Hew, S Li*, N Xia*, J Sivaraman*, 2015
Lessons from hepatitis E vaccine design, S Li1, J Zhang, N Xia*, 2015
The development of a recombinant hepatitis E vaccine HEV 239, S Li1, Q Zhao, T Wu*, S Chen, J Zhang, Xia, N Xia, 2015
Identification of Broad-Genotype HPV L2 Neutralization Site for Pan-HPV Vaccine Development by a Cross-Neutralizing Antibody, D Wang, Z Li, J Xiao, J Wang, L Zhang, Y Liu, F Fan, L Xin, M Wei, Z Kong, H Yu, Y Gu, J Zhang, S Li *, N Xia*, 2015
Structure of a Novel Shoulder-to-Shoulder p24 Dimer in Complex with the Broad-Spectrum Antibody A10F9 and Its Implication in Capsid Assembly, Y Gu, C Fang, W Lei, W Hou, J Zhang, C. l. Hew, S Li*, Y. A. Yuan*, Ningshao Xia*, 2013
Hepatitis E virus capsid protein assembles in 4M urea in the presence of salts, C Yang, H Pan, M Wei, X Zhang, N Wang, Y Gu, H Du, J Zhang, S Li*, N Xia*, 2013
Structural basis for the neutralization and genotype specificity of hepatitis E virus, X Tang, C Yang, Y Gu, C Song, X Zhang, Y Wang, J Zhang, C. L. Hew, S Li*, N Xia*, J Sivaraman *, 2011
Homology model and potential virus-capsid binding site of a putative HEV receptor Grp78, H Yu, S Li*, C Yang, M Wei, C Song, Z Zheng, Y Gu, H Du, J Zhang, N Xia, 2011
Expression and Purification of Soluble HIV-1 Envelope Glycoprotein gp160 Mutant from Saccharomyces Cerevisiae, K Yang, S Li*, F He, J Zhang, M Wei, H Pan, C Yang, J Xiong, J Zhang, N Xia, 2009
Dimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction, S Li#, X Tang#, J Seetharaman#, C Yang, Y Gu, J Zhang, H Du, J. W. Shih, C. L. Hew, J Sivaraman*, N Xia*, 2009
A bacterially expressed particulate hepatitis E vaccine: antigenicity, immunogenicity and protectivity on primates, S Li, J Zhang, Y Li, S Ou, G Huang, Z He, S Ge, Y Xian, S Pang, M. H. Ng, N Xia*, 2005
Mutational analysis of essential interactions involved in the assembly of hepatitis E virus capsid, S Li, J Zhang, Z He, Y Gu, R Liu, J Lin, Y Chen, M. H. Ng, N Xia*, 2005
