1995-2002 - Xiamen University, School of Life Sciences - Associate Professor
2002-Present - Xiamen University, School of Life Sciences - Professor, Doctoral Supervisor
2005-Present - Xiamen University, National Institute of Diagnostics and Vaccine Development in Infectious Diseases - Director
2011-2021 - Xiamen University, School of Public Health - Dean
National Technological Invention Second Prize
National Science and Technology Progress Second Prize
China Patent Gold Award
National Innovation Award
National Advanced Collective in Fighting COVID-19
Qiu Shi Outstanding Scientific Achievement Collective Award
Outstanding Contribution Award in Translational Medicine
Research
Infectious disease prevention and control Diagnostic reagents and vaccine development
Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating, Xu LF, Zheng QB, Zhu R, Yin ZC, Yu H, Lin Y, Wu YY, He MZ, Huang Y, Jiang YC, Sun H, Zha ZH, Yang HW, Huang QZ, Zhang DQ, Chen ZQ, Ye XZ, Han JL, Yang LS, Liu C, Que YQ, Fang MJ, Gu Y, Zhang J, Luo W, Zhou ZH, Li SW, Cheng T, Xia NS, 2021
Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16, He MZ, Xu LF, Zheng QB, Zhu R, Yin ZC, Zha ZH, Lin Y, Yang LS, Huang Y, Ye XZ, Li SX, Hou WH, Wu YT, Han JL, Liu DX, Li ZK, Chen ZQ, Yu H, Que YQ, Wang YB, Yan XD, Zhang J, Gu Y, Zhou ZH, Cheng T, Li SW, Xia NS, 2020
Near-atomic cryo-electron microscopy structures of varicella-zoster virus capsids, Wang W, Zheng QB, Pan DQ, Yu H, Fu WK, Liu J, He MZ, Zhu R, Cai YZ, Huang Y, Zha ZH, Chen ZQ, Ye XZ, Han JL, Que YQ, Wu T, Zhang J, Li SW, Zhu H, Zhou ZH, Cheng T, Xia NS, 2020
Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles, Wang DN, Liu XL, Wei MX, Qian CY, Song S, Chen J, Wang ZP, Xu Q, Yang YR, He MZ, Chi X, Huang SW, Li TT, Kong ZB, Zheng QB, Yu H, Wang YB, Zhao QJ, Zhang J, Xia NS, Gu Y, Li SW, 2020
Quantitative evaluation of protective antibody response induced by hepatitis E vaccine in humans, Wen GP, He LL, Tang ZM, Wang SL, Zhang X, Chen YZ, Lin XH, Liu C, Chen JX, Ying D, Chen ZH, Wang YB, Luo WX, Huang SJ, Li SW, Zhang J, Zheng ZZ, Zhu J, Xia NS, 2020
Virus-Free and Live-Cell Visualizing SARS-CoV-2 Cell Entry for Studies of Neutralizing Antibodies and Compound Inhibitors, Zhang YL, Wang SJ, Wu YT, Hou WH, Yuan LZ, Sheng CG, Wang J, Ye JH, Zheng QB, Ma J, Xu JJ, Wei M, Li ZL, Nian S, Xiong HL, Zhang L, Shi Y, Fu BR, Cao JL, Yang CL, Li ZY, Yang T, Liu L, Yu H, Hu JD, Ge SX, Chen YX, Zhang TY, Zhang J, Cheng T, Yuan Q, Xia NS, 2020
Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction, Zhang TY, Chen HY, Cao JL, Xiong HL, Mo XB, Li TL, Kang XZ, Zhao JH, Yin B, Zhao X, Huang CH, Yuan Q, Xue D, Xia NS, Yuan YA, 2019
Vesicular Antibodies: A Bioactive Multifunctional Combination Platform for Targeted Therapeutic Delivery and Cancer Immunotherapy, Liu X, Liu C, Zheng ZZ, Chen SY, Pang X, Xiang XC, Tang JX, Ren E, Chen YZ, You M, Wang XY, Chen XY, Luo WX, Liu G, Xia NS, 2019
HBV infection-induced liver cirrhosis development in dual-humanised mice with human bone mesenchymal stem cell transplantation, Yuan L, Jiang J, Liu X, Zhang Y, Zhang L, Xin J, Wu K, Li X, Cao J, Guo X, Shi D, Li J, Jiang L, Sun S, Wang T, Hou W, Zhang T, Zhu H, Zhang J, Yuan Q, Cheng T, Li J, Xia N, 2019
A unique B cell epitope-based particulate vaccine shows effective suppression of hepatitis B surface antigen in mice, Zhang T-Y, Guo X-R, Wu Y-T, Kang X-Z, Zheng Q-B, Qi R-Y, Chen B-B, Lan Y, Wei M, Wang S-J, Xiong H-L, Cao J-L, Zhang B-H, Qiao X-Y, Huang X-F, Wang Y-B, Fang M-J, Zhang Y-L, Cheng T, Chen Y-X, Zhao Q-J, Li S-W, Ge S-X, Chen P-J, Zhang J, Yuan Q, Xia N-S, 2020
Efficacy, safety, and immunogenicity of an Escherichia coli-produced bivalent human papillomavirus vaccine: An interim analysis of a randomized clinical trial, Qiao Y-L, Wu T, Li R-C, Hu Y-M, Wei L-H, Li C-G, Chen W, Huang S-J, Zhao F-H, Li M-Q, Pan Q-J, Zhang X, Li Q, Hong Y, Zhao C, Zhang W-H, Li Y-P, Chu K, Li M, Jiang Y-F, Li J, Zhao H, Lin Z-J, Cui X-L, Liu W-Y, Li C-H, Guo D-P, Ke L-D, Wu X, Tang J, Gao G-Q, Li B-Y, Zhao B, Zheng F-X, Dai C-H, Guo M, Zhao J, Su Y-Y, Wang J-Z, Zhu F-C, Li S-W, Pan H-R, Li Y-M, Zhang J, Xia N-S, 2020
Viral neutralization by antibody-imposed physical disruption, Zheng Q, Jiang J, He M, Zheng Z, Yu H, Li T, Xue W, Tang Z, Ying D, Li Z, Song S, Liu X, Wang K, Zhang Z, Wang D, Wang Y, Yan X, Zhao Q, Zhang J, Gu Y, Li S, Xia N, 2019
Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization, Zheng QB, Zhu R, Xu LF, He MZ, Yan XD, Liu DX, Yin ZC, Wu YT, Li YC, Yang LS, Hou WH, Li SX, Li ZZ, Chen ZQ, Li ZH, Yu H, Gu Y, Zhang J, Baker TS, Zhou ZH, Graham BS, Cheng T, Li SW, Xia NS, 2019
Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity, Li ZH, Song S, He MZ, Wang DN, Shi JJ, Liu XL, Li YB, Chi X, Wei SP, Yang YR, Wang ZP, Li JJ, Qian HL, Yu H, Zheng QB, Yan XD, Zhao QJ, Zhang J, Gu Y, Li SW, Xia NS, 2018
Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10, Zhu R, Xu LF, Zheng QB, Cui YX, Li SW, He MZ, Yin ZC, Liu DX, Li SX, Li ZZ, Chen ZQ, Yu H, Que YQ, Liu C, Kong Z, Zhang JB, Baker TS, Yan XD, Zhou ZH, Cheng T, Xia NS, 2018
A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses, Shen CG, Chen JY, Li R, Zhang MY, Wang GS, Stegalkina S, Zhang LM, Chen J, Cao JL, Bi XJ, Anderson SF, Alefantis T, Zhang MW, Cai XY, Yang KY, Zheng QB, Fang MJ, Yu H, Luo WX, Zheng ZZ, Yuan Q, Zhang J, Shih JWK, Kleanthous H, Chen HL, Chen YX, Xia NS, 2017
Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody, Xu LF, Zheng QB, Li SW, He MZ, Wu YT, Li YC, Zhu R, Yu H, Hong QY, Jiang J, Li ZZ, Li SX, Zhao H, Yang LS, Hou WH, Wang W, Ye XZ, Zhang J, Baker TS, Cheng T, Zhou ZH, Yan XD, Xia NS, 2017
Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein, Tian DY, Battles MB, Moin SM, Chen M, Modjarrad K, Kumar A, Kanekiyo M, Graepel KW, Taher NM, Hotard AL, Moore ML, Zhao M, Zheng ZZ, Xia NS, McLellan JS, Graham BS, 2017
Prolonged suppression of HBV in mice by a novel antibody that targets a unique epitope on hepatitis B surface antigen, Zhang TY, Yuan Q, Zhao JH, Zhang YL, Yuan LZ, Lan Y, Lo YC, Sun CP, Wu CR, Zhang JF, Zhang Y, Cao JL, Guo XR, Liu X, Mo XB, Luo WX, Cheng T, Chen YX, Tao MH, Shih JWK, Zhao QJ, Zhang J, Chen PJ, Yuan YA, Xia NS, 2016
Baseline quantitative hepatitis B core antibody titre alone strongly predicts HBeAg seroconversion across chronic hepatitis B patients treated with peginterferon or nucleos(t)ide analogues, Fan R, Sun J, Yuan Q, Xie Q, Bai XF, Ning Q, Cheng J, Yu YY, Niu JQ, Shi GF, Wang H, Tan DM, Wan MB, Chen SJ, Xu M, Chen XY, Tang H, Sheng JF, Lu FM, Jia JD, Zhuang H, Xia N, Hou J, Chronic Hepatitis BS, 2016
Serum Hepatitis B Virus Rna Is Encapsidated Pregenome Rna That May Be Associated with Persistence of Viral Infection and Rebound, Wang J, Shen T, Huang X, Kumar GR, Chen X, Zeng Z, Zhang R, Chen R, Li T, Zhang T, Yuan Q, Li P-C, Huang Q, Colonno R, Jia J, Hou J, McCrae MA, Gao Z, Ren H, Xia N, Zhuang H, Lu F, 2016
Long-Term Efficacy of a Hepatitis E Vaccine, Zhang J, Zhang XF, Huang SJ, Wu T, Hu YM, Wang ZZ, Wang H, Jiang HM, Wang YJ, Yan Q, Guo M, Liu XH, Li JX, Yang CL, Tang Q, Jiang RJ, Pan HR, Li YM, Shih JWK, Ng MH, Zhu FC, Xia NS, 2015
Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody, Gu Y, Tang XH, Zhang X, Song CL, Zheng MH, Wang KH, Zhang J, Ng MH, Hew CL, Li SW, Xia NS, Sivaraman J, 2015
Quantitative hepatitis B core antibody level may help predict treatment response in chronic hepatitis B patients, Yuan Q, Song LW, Liu CJ, Li Z, Liu PG, Huang CH, Yan Y, Ge SX, Wang YB, Peng CY, Zhang J, Kao J-H, Chen D-S, Chen PJ, Xia NS, 2013
Safety of hepatitis E vaccine for pregnant women: a preliminary analysis, Wu T, Zhu FC, Huang SJ, Zhang XF, Wang ZZ, Zhang J, Xia NS, 2012
Influence of mutations in hepatitis B virus surface protein on viral antigenicity and phenotype in occult HBV strains from blood donors, Cheng-Hao Huang, Quan Yuan, Pei-Jer Chen, Ya-Li Zhang, Chang-Rong Chen, Qing-Bing Zheng, Shiou-Hwei Yeh, Hai Yu, Yu Xue, Yi-Xin Chen, Ping-Guo Liu, Sheng-Xiang Ge, Jun Zhang, Ning-Shao Xia, 2012
Hepatitis B virus X protein targets Bcl-2 proteins to increase intracellular calcium, required for virus replication and cell death induction, Xin Geng, Chenghao Huang, Yan Qin, Janet E. McCombs, Quan Yuan, Brian L. Harry, Amy E. Palmer, Ning-Shao Xia, and Ding Xue, 2012
Structural basis for the neutralization and genotype specificity of hepatitis E virus, Xuhua Tang, Chunyan Yang, Ying Gu, Cuiling Song, Xiao Zhang, Yingbin Wang, Jun Zhang, Choy Leong Hew, Shaowei Li, Ningshao Xia, and J. Sivaraman, 2011
Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial, Zhu FC, Zhang J, Zhang XF, Zhou C, Wang ZZ, Huang SJ, Wang H, Yang CL, Jiang HM, Cai JP, Wang YJ, Ai X, Hu YM, Tang QA, Yao X, Yan QA, Xian YL, Wu T, Li YM, Miao J, Ng MH, Shih JWK, Xia NS, 2010
Area of Focus
Immunology | B-Cells | Antibodies | Somatic Hypermutation | Pathogens | Autoimmunity | Gut Microbiome | Host Interactions | Vaccines | Traditional Chinese Medicine
Area of Focus
Nanobodies | Medical Applications | Health Applications | Antibodies | Diagnostics | Targeted Drugs | Research Platform | Technology Development | Full Process | Advanced Techniques
