Professor | Li Li | Asia Growth Partners

	Upload Avatar (500 x 500)
Name	Li Li
Contact Information	lli@xmu.edu.cn
Language ability	English, Chinese
Province	Fujian

Upload Avatar (500 x 500)

Name

Li Li

Contact Information

lli@xmu.edu.cn

Language ability

English, Chinese

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	2008 - B.S. in Life Science: Xiamen University 2013 - Ph.D. in Cellular and Molecular Biology: Xiamen University
Work Experience	2015-2018 - Engineer, Xiamen University 2019-Present - Assistant Professor, School of Life Sciences, Xiamen University
Awards	Fujian Provincial Natural Science First Prize (2017)

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

2008 - B.S. in Life Science: Xiamen University
2013 - Ph.D. in Cellular and Molecular Biology: Xiamen University

Work Experience

2015-2018 - Engineer, Xiamen University
2019-Present - Assistant Professor, School of Life Sciences, Xiamen University

Awards

Fujian Provincial Natural Science First Prize (2017)

Areas of Focus	Discovery and mechanistic research of bioactive natural products Functional and regulatory mechanism study on potential therapeutic targets
Publications	Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation., Li, L.; Liu, Y.; Chen, H. Z.; Li, F. W.; Wu, J. F.; Zhang, H. K.; He, J. P.; Xing, Y. Z.; Chen, Y.; Wang, W. J.; Tian, X. Y.; Li, A. Z.; Zhang, Q.; Huang, P. Q.; Han, J.; Lin, T.; Wu, Q., 2015 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer., Wang, Y.; Zhang, L.; Wei, Y.; Huang, W.; Li, L.; Wu, A. A.; Dastur, A.; Greninger, P.; Bray, W. M.; Zhang, C. S.; Li, M.; Lian, W.; Hu, Z.; Wang, X.; Liu, G.; Yao, L.; Guh, J. H.; Chen, L.; Wang, H. R.; Zhou, D.; Lin, S. C.; Xu, Q.; Shen, Y.; Zhang, J.; Jurica, M. S.; Benes, C. H.; Deng, X., 2020 Tandem-Mass-Tag Based Proteomic Analysis Facilitates Analyzing Critical Factors of Porous Silicon Nanoparticles in Determining Their Biological Responses under Diseased Condition., Li, Y.; Liu, Z.; Li, L.; Lian, W.; He, Y.; Khalil, E.; Makila, E.; Zhang, W.; Torrieri, G.; Liu, X.; Su, J.; Xiu, Y.; Fontana, F.; Salonen, J.; Hirvonen, J.; Liu, W.; Zhang, H.; Santos, H. A.; Deng, X., 2020 The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling., Chen, H. Z.; Liu, Q. F.; Li, L.; Wang, W. J.; Yao, L. M.; Yang, M.; Liu, B.; Chen, W.; Zhan, Y. Y.; Zhang, M. Q.; Cai, J. C.; Zheng, Z. H.; Lin, S. C.; Li, B. A.; Wu, Q., 2012 A new ALK inhibitor overcomes resistance to first- and second-generation inhibitors in NSCLC., Lu, Y.; Fan, Z.; Zhu, S. J.; Huang, X.; Zhuang, Z.; Li, Y.; Deng, Z.; Gao, L.; Hong, X.; Zhang, T.; Li, L.; Sun, X.; Huang, W.; Zhang, J.; Liu, Y.; Zhang, B.; Jiang, J.; Gui, F.; Wang, Z.; Li, Q.; Song, S.; Huang, X.; Wu, Q.; Chen, L.; Zhou, D.; Zhang, J.; Yun, C. H.; Chen, L.; Deng, X., 2022 Pharmacological targeting PIKfyve and tubulin as an effective treatment strategy for double-hit lymphoma., Feng, L.; Chen, K.; Huang, W.; Jiang, Y.; Sun, X.; Zhou, Y.; Li, L.; Li, Y.; Deng, X.; Xu, B., 2022 Biosynthesis and Chemical Diversification of Verucopeptin Leads to Structural and Functional Versatility., Zhang, L.; Wang, Y.; Huang, W.; Wei, Y.; Jiang, Z.; Kong, L.; Wu, A. A.; Hu, Z.; Huang, H.; Xu, Q.; Li, L.; Deng, X., 2020 Blocking PPARgamma interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression., Yang, P. B.; Hou, P. P.; Liu, F. Y.; Hong, W. B.; Chen, H. Z.; Sun, X. Y.; Li, P.; Zhang, Y.; Ju, C. Y.; Luo, L. J.; Wu, S. F.; Zhou, J. X.; Wang, Z. J.; He, J. P.; Li, L.; Zhao, T. J.; Deng, X.; Lin, T.; Wu, Q., 2020 Discovery of 4-methyl-N- (4-((4-methylpiperazin-1-yl)methyl) -3- (trifluoromethyl)phenyl) -3- ((6-(pyridin-3-yl) -1H-pyrazolo [3,4-d] pyrimidin-4-yl)-oxy)benzamide as a potent inhibitor of RET and its gatekeeper mutant., Li, X.; Su, J.; Yang, Y.; Lian, W.; Deng, Z.; Yang, Z.; Chen, G.; Zhang, B.; Dong, C.; Liu, X.; Li, L.; Wang, Z.; Hu, Z.; Xu, Q.; Deng, X., 2020 Targeting RIPK3 oligomerization blocks necroptosis without inducing apoptosis., Li, W.; Ni, H.; Wu, S.; Han, S.; Chen, C.; Li, L.; Li, Y.; Gui, F.; Han, J.; Deng, X., 2020 Discovery of methyl 3-((2-((1-(dimethylglycyl)-5-methoxyindolin-6-yl)amino)-5-(trifluoro-methyl) pyrimidin-4-yl)amino)thiophene-2-carboxylate as a potent and selective polo-like kinase 1 (PLK1) inhibitor for combating hepatocellular carcinoma., Deng, Z.; Chen, G.; Liu, S.; Li, Y.; Zhong, J.; Zhang, B.; Li, L.; Huang, H.; Wang, Z.; Xu, Q.; Deng, X., 2020 Discovery and optimization of 4-oxo-2-thioxo-thiazolidinones as NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inhibitors., Chen, Y.; He, H.; Jiang, H.; Li, L.; Hu, Z.; Huang, H.; Xu, Q.; Zhou, R.; Deng, X., 2020 Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis., Yin, C.; Zhu, B.; Zhang, T.; Liu, T.; Chen, S.; Liu, Y.; Li, X.; Miao, X.; Li, S.; Mi, X.; Zhang, J.; Li, L.; Wei, G.; Xu, Z. X.; Gao, X.; Huang, C.; Wei, Z.; Goding, C. R.; Wang, P.; Deng, X.; Cui, R., 2019 A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases., Tian, M.; Zeng, T.; Liu, M.; Han, S.; Lin, H.; Lin, Q.; Li, L.; Jiang, T.; Li, G.; Lin, H.; Zhang, T.; Kang, Q.; Deng, X.; Wang, H. R., 2019 Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing., Liu, Z. H.; Li, Y. Z.; Li, W.; Lian, W. H.; Kemell, M.; Hietala, S.; Figueiredo, P.; Li, L.; Makila, E.; Ma, M.; Salonen, J.; Hirvonen, J. T.; Liu, D. F.; Zhang, H. B.; Deng, X. M.; Santos, H. A., 2019 A non-covalent inhibitor XMU-MP-3 overrides ibrutinib-resistant Btk(C481S) mutation in B-cell malignancies., Gui, F.; Jiang, J.; He, Z.; Li, L.; Li, Y.; Deng, Z.; Lu, Y.; Wu, X.; Chen, G.; Su, J.; Song, S.; Zhang, Y. M.; Yun, C. H.; Huang, X.; Weisberg, E.; Zhang, J.; Deng, X., 2019 Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities., Huang, W.; Sun, X.; Li, Y.; He, Z.; Li, L.; Deng, Z.; Huang, X.; Han, S.; Zhang, T.; Zhong, J.; Wang, Z.; Xu, Q.; Zhang, J.; Deng, X., 2018 Mycoepoxydiene suppresses HeLa cell growth by inhibiting glycolysis and the pentose phosphate pathway., Jin, K.; Li, L.; Sun, X.; Xu, Q.; Song, S.; Shen, Y.; Deng, X., 2017 Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors., Jiang, J.; Gui, F.; He, Z.; Li, L.; Li, Y.; Li, S.; Wu, X.; Deng, Z.; Sun, X.; Huang, X.; Huang, W.; Han, S.; Zhang, T.; Wang, Z.; Jiao, B.; Song, S.; Wang, H.; Chen, L.; Zhou, D.; Liu, Q.; Ren, R.; Zhang, J.; Deng, X., 2017 Structure Determinants of Lagunamide A for Anticancer Activity and Its Molecular Mechanism of Mitochondrial Apoptosis., Huang, X.; Huang, W.; Li, L.; Sun, X.; Song, S.; Xu, Q.; Zhang, L.; Wei, B. G.; Deng, X., 2016 Enhancement of hypothalamic STAT3 acetylation by nuclear receptor Nur77 dictates leptin sensitivity., Chen, Y.; Wu, R.; Chen, H. Z.; Xiao, Q.; Wang, W. J.; He, J. P.; Li, X. X.; Yu, X. W.; Li, L.; Wang, P.; Wan, X. C.; Tian, X. H.; Li, S. J.; Yu, X.; Wu, Q., 2015 Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway., Wang, W. J.; Wang, Y.; Chen, H. Z.; Xing, Y. Z.; Li, F. W.; Zhang, Q.; Zhou, B.; Zhang, H. K.; Zhang, J.; Bian, X. L.; Li, L.; Liu, Y.; Zhao, B. X.; Chen, Y.; Wu, R.; Li, A. Z.; Yao, L. M.; Chen, P.; Zhang, Y.; Tian, X. Y.; Beermann, F.; Wu, M.; Han, J.; Huang, P. Q.; Lin, T.; Wu, Q., 2014 Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells., Lee, S. O.; Li, X.; Hedrick, E.; Jin, U. H.; Tjalkens, R. B.; Backos, D. S.; Li, L.; Zhang, Y.; Wu, Q.; Safe, S., 2014 Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis., Chen, H. Z.; Li, L.; Wang, W. J.; Du, X. D.; Wen, Q.; He, J. P.; Zhao, B. X.; Li, G. D.; Zhou, W.; Xia, Y.; Yang, Q. Y.; Hew, C. L.; Liou, Y. C.; Wu, Q., 2012 Akt phosphorylates the TR3 orphan receptor and blocks its targeting to the mitochondria., Chen, H. Z.; Zhao, B. X.; Zhao, W. X.; Li, L.; Zhang, B.; Wu, Q., 2008

Areas of Focus

Discovery and mechanistic research of bioactive natural products
Functional and regulatory mechanism study on potential therapeutic targets

Publications

Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation., Li, L.; Liu, Y.; Chen, H. Z.; Li, F. W.; Wu, J. F.; Zhang, H. K.; He, J. P.; Xing, Y. Z.; Chen, Y.; Wang, W. J.; Tian, X. Y.; Li, A. Z.; Zhang, Q.; Huang, P. Q.; Han, J.; Lin, T.; Wu, Q., 2015
Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer., Wang, Y.; Zhang, L.; Wei, Y.; Huang, W.; Li, L.; Wu, A. A.; Dastur, A.; Greninger, P.; Bray, W. M.; Zhang, C. S.; Li, M.; Lian, W.; Hu, Z.; Wang, X.; Liu, G.; Yao, L.; Guh, J. H.; Chen, L.; Wang, H. R.; Zhou, D.; Lin, S. C.; Xu, Q.; Shen, Y.; Zhang, J.; Jurica, M. S.; Benes, C. H.; Deng, X., 2020
Tandem-Mass-Tag Based Proteomic Analysis Facilitates Analyzing Critical Factors of Porous Silicon Nanoparticles in Determining Their Biological Responses under Diseased Condition., Li, Y.; Liu, Z.; Li, L.; Lian, W.; He, Y.; Khalil, E.; Makila, E.; Zhang, W.; Torrieri, G.; Liu, X.; Su, J.; Xiu, Y.; Fontana, F.; Salonen, J.; Hirvonen, J.; Liu, W.; Zhang, H.; Santos, H. A.; Deng, X., 2020
The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling., Chen, H. Z.; Liu, Q. F.; Li, L.; Wang, W. J.; Yao, L. M.; Yang, M.; Liu, B.; Chen, W.; Zhan, Y. Y.; Zhang, M. Q.; Cai, J. C.; Zheng, Z. H.; Lin, S. C.; Li, B. A.; Wu, Q., 2012
A new ALK inhibitor overcomes resistance to first- and second-generation inhibitors in NSCLC., Lu, Y.; Fan, Z.; Zhu, S. J.; Huang, X.; Zhuang, Z.; Li, Y.; Deng, Z.; Gao, L.; Hong, X.; Zhang, T.; Li, L.; Sun, X.; Huang, W.; Zhang, J.; Liu, Y.; Zhang, B.; Jiang, J.; Gui, F.; Wang, Z.; Li, Q.; Song, S.; Huang, X.; Wu, Q.; Chen, L.; Zhou, D.; Zhang, J.; Yun, C. H.; Chen, L.; Deng, X., 2022
Pharmacological targeting PIKfyve and tubulin as an effective treatment strategy for double-hit lymphoma., Feng, L.; Chen, K.; Huang, W.; Jiang, Y.; Sun, X.; Zhou, Y.; Li, L.; Li, Y.; Deng, X.; Xu, B., 2022
Biosynthesis and Chemical Diversification of Verucopeptin Leads to Structural and Functional Versatility., Zhang, L.; Wang, Y.; Huang, W.; Wei, Y.; Jiang, Z.; Kong, L.; Wu, A. A.; Hu, Z.; Huang, H.; Xu, Q.; Li, L.; Deng, X., 2020
Blocking PPARgamma interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression., Yang, P. B.; Hou, P. P.; Liu, F. Y.; Hong, W. B.; Chen, H. Z.; Sun, X. Y.; Li, P.; Zhang, Y.; Ju, C. Y.; Luo, L. J.; Wu, S. F.; Zhou, J. X.; Wang, Z. J.; He, J. P.; Li, L.; Zhao, T. J.; Deng, X.; Lin, T.; Wu, Q., 2020
Discovery of 4-methyl-N- (4-((4-methylpiperazin-1-yl)methyl) -3- (trifluoromethyl)phenyl) -3- ((6-(pyridin-3-yl) -1H-pyrazolo [3,4-d] pyrimidin-4-yl)-oxy)benzamide as a potent inhibitor of RET and its gatekeeper mutant., Li, X.; Su, J.; Yang, Y.; Lian, W.; Deng, Z.; Yang, Z.; Chen, G.; Zhang, B.; Dong, C.; Liu, X.; Li, L.; Wang, Z.; Hu, Z.; Xu, Q.; Deng, X., 2020
Targeting RIPK3 oligomerization blocks necroptosis without inducing apoptosis., Li, W.; Ni, H.; Wu, S.; Han, S.; Chen, C.; Li, L.; Li, Y.; Gui, F.; Han, J.; Deng, X., 2020
Discovery of methyl 3-((2-((1-(dimethylglycyl)-5-methoxyindolin-6-yl)amino)-5-(trifluoro-methyl) pyrimidin-4-yl)amino)thiophene-2-carboxylate as a potent and selective polo-like kinase 1 (PLK1) inhibitor for combating hepatocellular carcinoma., Deng, Z.; Chen, G.; Liu, S.; Li, Y.; Zhong, J.; Zhang, B.; Li, L.; Huang, H.; Wang, Z.; Xu, Q.; Deng, X., 2020
Discovery and optimization of 4-oxo-2-thioxo-thiazolidinones as NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inhibitors., Chen, Y.; He, H.; Jiang, H.; Li, L.; Hu, Z.; Huang, H.; Xu, Q.; Zhou, R.; Deng, X., 2020
Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis., Yin, C.; Zhu, B.; Zhang, T.; Liu, T.; Chen, S.; Liu, Y.; Li, X.; Miao, X.; Li, S.; Mi, X.; Zhang, J.; Li, L.; Wei, G.; Xu, Z. X.; Gao, X.; Huang, C.; Wei, Z.; Goding, C. R.; Wang, P.; Deng, X.; Cui, R., 2019
A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases., Tian, M.; Zeng, T.; Liu, M.; Han, S.; Lin, H.; Lin, Q.; Li, L.; Jiang, T.; Li, G.; Lin, H.; Zhang, T.; Kang, Q.; Deng, X.; Wang, H. R., 2019
Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing., Liu, Z. H.; Li, Y. Z.; Li, W.; Lian, W. H.; Kemell, M.; Hietala, S.; Figueiredo, P.; Li, L.; Makila, E.; Ma, M.; Salonen, J.; Hirvonen, J. T.; Liu, D. F.; Zhang, H. B.; Deng, X. M.; Santos, H. A., 2019
A non-covalent inhibitor XMU-MP-3 overrides ibrutinib-resistant Btk(C481S) mutation in B-cell malignancies., Gui, F.; Jiang, J.; He, Z.; Li, L.; Li, Y.; Deng, Z.; Lu, Y.; Wu, X.; Chen, G.; Su, J.; Song, S.; Zhang, Y. M.; Yun, C. H.; Huang, X.; Weisberg, E.; Zhang, J.; Deng, X., 2019
Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities., Huang, W.; Sun, X.; Li, Y.; He, Z.; Li, L.; Deng, Z.; Huang, X.; Han, S.; Zhang, T.; Zhong, J.; Wang, Z.; Xu, Q.; Zhang, J.; Deng, X., 2018
Mycoepoxydiene suppresses HeLa cell growth by inhibiting glycolysis and the pentose phosphate pathway., Jin, K.; Li, L.; Sun, X.; Xu, Q.; Song, S.; Shen, Y.; Deng, X., 2017
Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors., Jiang, J.; Gui, F.; He, Z.; Li, L.; Li, Y.; Li, S.; Wu, X.; Deng, Z.; Sun, X.; Huang, X.; Huang, W.; Han, S.; Zhang, T.; Wang, Z.; Jiao, B.; Song, S.; Wang, H.; Chen, L.; Zhou, D.; Liu, Q.; Ren, R.; Zhang, J.; Deng, X., 2017
Structure Determinants of Lagunamide A for Anticancer Activity and Its Molecular Mechanism of Mitochondrial Apoptosis., Huang, X.; Huang, W.; Li, L.; Sun, X.; Song, S.; Xu, Q.; Zhang, L.; Wei, B. G.; Deng, X., 2016
Enhancement of hypothalamic STAT3 acetylation by nuclear receptor Nur77 dictates leptin sensitivity., Chen, Y.; Wu, R.; Chen, H. Z.; Xiao, Q.; Wang, W. J.; He, J. P.; Li, X. X.; Yu, X. W.; Li, L.; Wang, P.; Wan, X. C.; Tian, X. H.; Li, S. J.; Yu, X.; Wu, Q., 2015
Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway., Wang, W. J.; Wang, Y.; Chen, H. Z.; Xing, Y. Z.; Li, F. W.; Zhang, Q.; Zhou, B.; Zhang, H. K.; Zhang, J.; Bian, X. L.; Li, L.; Liu, Y.; Zhao, B. X.; Chen, Y.; Wu, R.; Li, A. Z.; Yao, L. M.; Chen, P.; Zhang, Y.; Tian, X. Y.; Beermann, F.; Wu, M.; Han, J.; Huang, P. Q.; Lin, T.; Wu, Q., 2014
Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells., Lee, S. O.; Li, X.; Hedrick, E.; Jin, U. H.; Tjalkens, R. B.; Backos, D. S.; Li, L.; Zhang, Y.; Wu, Q.; Safe, S., 2014
Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis., Chen, H. Z.; Li, L.; Wang, W. J.; Du, X. D.; Wen, Q.; He, J. P.; Zhao, B. X.; Li, G. D.; Zhou, W.; Xia, Y.; Yang, Q. Y.; Hew, C. L.; Liou, Y. C.; Wu, Q., 2012
Akt phosphorylates the TR3 orphan receptor and blocks its targeting to the mitochondria., Chen, H. Z.; Zhao, B. X.; Zhao, W. X.; Li, L.; Zhang, B.; Wu, Q., 2008

Natural Products Drug Development Biosynthetic Approaches Chemoproteomic Therapeutic Targets Small Molecules Kinases Epigenetic Enzymes Lead Compounds Molecular Mechanisms

Hua Gu - Tongji University

Yang Xiaotong - Shanghai Normal University

Chunguang Wang - Tongji University

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us