Professor | Jiahuai Han | Asia Growth Partners

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Name	Jiahuai Han
Contact Information	jhan@xmu.edu.cn
Language ability	English, Chinese
Province	Fujian

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Name

Jiahuai Han

Contact Information

jhan@xmu.edu.cn

Language ability

English, Chinese

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Medical
Academic Background & Achievements	1978-1982 B.S. in Biochemistry: Beijing University 1982-1985 M.S. in Protein Chemistry: Beijing University 1985-1990 Ph.D. in Molecular Biology: University of Brussels 2013 Academician of the Chinese Academy of Sciences
Work Experience	1990-1992 Research Fellow, University of Texas Southwestern Medical Center 1992-1993 Research Associate, The Scripps Research Institute 1993-1996 Assistant Member, The Scripps Research Institute 1996-2004 Associate Professor, The Scripps Research Institute 2004-2007 Professor, The Scripps Research Institute 2002-2007 Adjunct Professor, Xiamen University 2007-present Professor, Xiamen University Dean, Faculty of Medicine and Life Sciences, Xiamen University Director, State Key Laboratory of Cellular Stress Biology Director, Laboratory Animal Center, Xiamen University Vice President, Xiamen University
Awards	2013: Academician of the Chinese Academy of Sciences

University/Lab Affiliation and Title

Xiamen University

Faculty

Medical

Academic Background & Achievements

1978-1982 B.S. in Biochemistry: Beijing University
1982-1985 M.S. in Protein Chemistry: Beijing University
1985-1990 Ph.D. in Molecular Biology: University of Brussels
2013 Academician of the Chinese Academy of Sciences

Work Experience

1990-1992 Research Fellow, University of Texas Southwestern Medical Center
1992-1993 Research Associate, The Scripps Research Institute
1993-1996 Assistant Member, The Scripps Research Institute
1996-2004 Associate Professor, The Scripps Research Institute
2004-2007 Professor, The Scripps Research Institute
2002-2007 Adjunct Professor, Xiamen University
2007-present Professor, Xiamen University
Dean, Faculty of Medicine and Life Sciences, Xiamen University
Director, State Key Laboratory of Cellular Stress Biology
Director, Laboratory Animal Center, Xiamen University
Vice President, Xiamen University

Awards

2013: Academician of the Chinese Academy of Sciences

Areas of Focus	Cellular stress responses in physiological and pathological processes Molecular mechanisms in cellular stress responses including inflammation and related diseases
Publications	Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion, He WT, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J, 2015 Group-DIA: analyzing multiple data-independent acquisition mass spectrometry data files, Li Y, Zhong CQ, Xu X, Cai S, Wu X, Zhang Y, Chen J, Shi J, Lin S, Han J, 2015 Ppm1b negatively regulates necroptosis through dephosphorylating Rip3, Chen W, Wu J, Li L, Zhang Z, Ren J, Liang Y, Chen F, Yang C, Zhou Z, Sean Su S, Zheng X, Zhang Z, Zhong CQ, Wan H, Xiao M, Lin X, Feng XH, Han J, 2015 RIP1/RIP3 Binding to HSV-1 ICP6 Initiates Necroptosis to Restrict Virus Propagation in Mice, Huang Z, Wu SQ, Liang Y, Zhou X, Chen W, Li L, Wu J, Zhuang Q, Chen C, Li J, Zhong CQ, Xia W, Zhou R, Zheng C, Han J, 2015 Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death, Chen X, Li W, Ren J, Huang D, He WT, Song Y, Yang C, Li W, Zheng X, Chen P, Han J, 2013 RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis, Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J, 2009 PRAK is essential for ras-induced senescence and tumor suppression, Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong MQ, Frangou CG, Yates JR, 3rd, Wright PE, Han J, 2007 Involvement of microRNA in AU-rich element-mediated mRNA instability, Jing Q, Huang S, Guth S, Zarubin T, Motoyama A, Chen J, DiPadova F, Lin SC, Gram H, Han J, 2005 MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha, Ge B, Gram H, DiPadova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J, 2002 Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation, Han J, Jiang Y, Li Z, Kravchenko VV, Ulevitch RJ, 1997 A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells, Han J, Lee JD, Bibbs L, Ulevitch RJ, 1994

Areas of Focus

Cellular stress responses in physiological and pathological processes
Molecular mechanisms in cellular stress responses including inflammation and related diseases

Publications

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion, He WT, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J, 2015
Group-DIA: analyzing multiple data-independent acquisition mass spectrometry data files, Li Y, Zhong CQ, Xu X, Cai S, Wu X, Zhang Y, Chen J, Shi J, Lin S, Han J, 2015
Ppm1b negatively regulates necroptosis through dephosphorylating Rip3, Chen W, Wu J, Li L, Zhang Z, Ren J, Liang Y, Chen F, Yang C, Zhou Z, Sean Su S, Zheng X, Zhang Z, Zhong CQ, Wan H, Xiao M, Lin X, Feng XH, Han J, 2015
RIP1/RIP3 Binding to HSV-1 ICP6 Initiates Necroptosis to Restrict Virus Propagation in Mice, Huang Z, Wu SQ, Liang Y, Zhou X, Chen W, Li L, Wu J, Zhuang Q, Chen C, Li J, Zhong CQ, Xia W, Zhou R, Zheng C, Han J, 2015
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death, Chen X, Li W, Ren J, Huang D, He WT, Song Y, Yang C, Li W, Zheng X, Chen P, Han J, 2013
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis, Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J, 2009
PRAK is essential for ras-induced senescence and tumor suppression, Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong MQ, Frangou CG, Yates JR, 3rd, Wright PE, Han J, 2007
Involvement of microRNA in AU-rich element-mediated mRNA instability, Jing Q, Huang S, Guth S, Zarubin T, Motoyama A, Chen J, DiPadova F, Lin SC, Gram H, Han J, 2005
MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha, Ge B, Gram H, DiPadova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J, 2002
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation, Han J, Jiang Y, Li Z, Kravchenko VV, Ulevitch RJ, 1997
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells, Han J, Lee JD, Bibbs L, Ulevitch RJ, 1994

Cellular Stress Physiological Processes Pathological Processes Gene Mutation Gene Knockout Signal Pathways Immune Inflammation Tumor Development Cell Differentiation Cell Death

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