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Jiahuai Han
Medical School
Xiamen University
Fujian
Language: English, Chinese
Cellular Stress
Physiological Processes
Pathological Processes
Gene Mutation
Gene Knockout
Signal Pathways
Immune Inflammation
Tumor Development
Cell Differentiation
Cell Death
Areas of Focus
- Cellular stress responses in physiological and pathological processes
- Molecular mechanisms in cellular stress responses including inflammation and related diseases
Work Experience
- 1990-1992 Research Fellow, University of Texas Southwestern Medical Center
- 1992-1993 Research Associate, The Scripps Research Institute
- 1993-1996 Assistant Member, The Scripps Research Institute
- 1996-2004 Associate Professor, The Scripps Research Institute
- 2004-2007 Professor, The Scripps Research Institute
- 2002-2007 Adjunct Professor, Xiamen University
- 2007-present Professor, Xiamen University
- Dean, Faculty of Medicine and Life Sciences, Xiamen University
- Director, State Key Laboratory of Cellular Stress Biology
- Director, Laboratory Animal Center, Xiamen University
- Vice President, Xiamen University
Academic Background & Achievements
- 1978-1982 B.S. in Biochemistry: Beijing University
- 1982-1985 M.S. in Protein Chemistry: Beijing University
- 1985-1990 Ph.D. in Molecular Biology: University of Brussels
- 2013 Academician of the Chinese Academy of Sciences
Publications
- Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion, He WT, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J, 2015
- Group-DIA: analyzing multiple data-independent acquisition mass spectrometry data files, Li Y, Zhong CQ, Xu X, Cai S, Wu X, Zhang Y, Chen J, Shi J, Lin S, Han J, 2015
- Ppm1b negatively regulates necroptosis through dephosphorylating Rip3, Chen W, Wu J, Li L, Zhang Z, Ren J, Liang Y, Chen F, Yang C, Zhou Z, Sean Su S, Zheng X, Zhang Z, Zhong CQ, Wan H, Xiao M, Lin X, Feng XH, Han J, 2015
- RIP1/RIP3 Binding to HSV-1 ICP6 Initiates Necroptosis to Restrict Virus Propagation in Mice, Huang Z, Wu SQ, Liang Y, Zhou X, Chen W, Li L, Wu J, Zhuang Q, Chen C, Li J, Zhong CQ, Xia W, Zhou R, Zheng C, Han J, 2015
- Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death, Chen X, Li W, Ren J, Huang D, He WT, Song Y, Yang C, Li W, Zheng X, Chen P, Han J, 2013
- RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis, Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J, 2009
- PRAK is essential for ras-induced senescence and tumor suppression, Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong MQ, Frangou CG, Yates JR, 3rd, Wright PE, Han J, 2007
- Involvement of microRNA in AU-rich element-mediated mRNA instability, Jing Q, Huang S, Guth S, Zarubin T, Motoyama A, Chen J, DiPadova F, Lin SC, Gram H, Han J, 2005
- MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha, Ge B, Gram H, DiPadova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J, 2002
- Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation, Han J, Jiang Y, Li Z, Kravchenko VV, Ulevitch RJ, 1997
- A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells, Han J, Lee JD, Bibbs L, Ulevitch RJ, 1994
Awards
- 2013: Academician of the Chinese Academy of Sciences
