Professor | Yang Li | Asia Growth Partners

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Name	Yang Li
Contact Information	younglee@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

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Name

Yang Li

Contact Information

younglee@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Academic Background & Achievements	2008.9-2012.6 Bachelor of Science: Sichuan University 2012.9-2018.12 Doctor of Science: Zhejiang University Developed a molecular tool for precise manipulation of RNA m1A modification based on the CRISPR/Cas13 system Elucidated the function and molecular mechanism of transcription factor KLF9 in distal metastasis of gastric cancer Established a low-immunogenic human embryonic stem cell line by targeted knockout of the CIITA gene using TALEN technology
Work Experience	2019.7-2021.12 - Sichuan Normal University - Assistant Researcher 2022.1-2022.11 - West China Hospital, Sichuan University - Assistant Researcher 2022.12-present - The Fourth Affiliated Hospital, Zhejiang University School of Medicine - Distinguished Researcher

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Academic Background & Achievements

2008.9-2012.6 Bachelor of Science: Sichuan University
2012.9-2018.12 Doctor of Science: Zhejiang University
Developed a molecular tool for precise manipulation of RNA m1A modification based on the CRISPR/Cas13 system
Elucidated the function and molecular mechanism of transcription factor KLF9 in distal metastasis of gastric cancer
Established a low-immunogenic human embryonic stem cell line by targeted knockout of the CIITA gene using TALEN technology

Work Experience

2019.7-2021.12 - Sichuan Normal University - Assistant Researcher
2022.1-2022.11 - West China Hospital, Sichuan University - Assistant Researcher
2022.12-present - The Fourth Affiliated Hospital, Zhejiang University School of Medicine - Distinguished Researcher

Areas of Focus	Function and molecular mechanism of RNA modification in physiological and pathological processes Development and optimization of novel gene editing tools
Publications	Inducible RNA targeting and N6-methyladenosine editing by a split-Cas13 architecture, Li, Y#,., Sun, Q#., Yang, Z#., Yuan, G., 2023 Long-read sequencing reveals the landscape of aberrant alternative splicing and novel therapeutic target in colorectal cancer, Sun, Q#., Han, Y#., He, J#., Ma, X., Ning, Q., Zhao, Q., Jin, Q., Yang, L., Li, S., Li, Y., Zhi, Q., Zheng, J., Dong, D., 2023 Programmable RNA N1-Methyladenosine Demethylation by a Cas13d-Directed Demethylase, Xie, S#., Jin, H#., Yang, F#., Zheng, H#., Chang, Y., Liao, Y., Zhang, Y., Zhou, T., Li, Y., 2021 KLF9 suppresses gastric cancer invasion and metastasis through transcriptional inhibition of MMP28, Li, Y#., Sun, Q#., Jiang, M., Li, S., Zhang, J., Xu, Z., Guo, D., Gu, T., Wang, B., Xiao, L., Zhou, T., Zhuo, W., 2019 FTO-mediated m6A modification of SOCS1 mRNA promotes the progression of diabetic kidney disease, Sun, Q#,., Geng, H#., Zhao, M#., Li, Y#., Chen, X., Sha, Q., Lai, P., Tang, D., Yang, D., Liang, J., Guo, M., 2022 Functional disruption of human leukocyte antigen II in human embryonic stem cell, Chen, H#., Li, Y#., Lin, X., Cui, D., Cui, C., Li, H., Xiao, L., 2015 Combining gene expression signature with clinical features for survival stratification of gastric cancer, Sun, Q#., Guo, D#., Li, S#., Xu, Y., Jiang, M., Li, Y., Duan, H., Zhuo, W., Liu, W., Zhu, S., Wang, L., Zhou, T., 2021 Prebiotics Inulin Metabolism by Lactic Acid Bacteria From Young Rabbits, Zhu, Y#,*., Yue, S#., Li, R#., Qiu, S., Xu, Z., Wu, Y., Yao, J., Zuo, Y., Li, K., Li, Y., 2021

Areas of Focus

Function and molecular mechanism of RNA modification in physiological and pathological processes
Development and optimization of novel gene editing tools

Publications

Inducible RNA targeting and N6-methyladenosine editing by a split-Cas13 architecture, Li, Y#,*., Sun, Q#., Yang, Z#., Yuan, G*., 2023
Long-read sequencing reveals the landscape of aberrant alternative splicing and novel therapeutic target in colorectal cancer, Sun, Q#., Han, Y#., He, J#., Ma, X., Ning, Q., Zhao, Q., Jin, Q., Yang, L., Li, S., Li, Y., Zhi, Q*., Zheng, J*., Dong, D*., 2023
Programmable RNA N1-Methyladenosine Demethylation by a Cas13d-Directed Demethylase, Xie, S#., Jin, H#., Yang, F#., Zheng, H#., Chang, Y., Liao, Y., Zhang, Y*., Zhou, T*., Li, Y*., 2021
KLF9 suppresses gastric cancer invasion and metastasis through transcriptional inhibition of MMP28, Li, Y#., Sun, Q#., Jiang, M., Li, S., Zhang, J., Xu, Z., Guo, D., Gu, T., Wang, B., Xiao, L., Zhou, T*., Zhuo, W*., 2019
FTO-mediated m6A modification of SOCS1 mRNA promotes the progression of diabetic kidney disease, Sun, Q#,*., Geng, H#., Zhao, M#., Li, Y#., Chen, X., Sha, Q., Lai, P., Tang, D., Yang, D., Liang, J*., Guo, M*., 2022
Functional disruption of human leukocyte antigen II in human embryonic stem cell, Chen, H#., Li, Y#., Lin, X., Cui, D., Cui, C., Li, H., Xiao, L*., 2015
Combining gene expression signature with clinical features for survival stratification of gastric cancer, Sun, Q#., Guo, D#., Li, S#., Xu, Y., Jiang, M., Li, Y., Duan, H., Zhuo, W., Liu, W., Zhu, S., Wang, L*., Zhou, T*., 2021
Prebiotics Inulin Metabolism by Lactic Acid Bacteria From Young Rabbits, Zhu, Y#,*., Yue, S#., Li, R#., Qiu, S., Xu, Z., Wu, Y., Yao, J., Zuo, Y., Li, K., Li, Y., 2021

Rna Modification Molecular Mechanism Physiological Processes Pathological Processes Gene Editing Crispr Cas13 Talen Klf9 Gastric Cancer

Baohui Chen - Zhejiang University

Dan Du - Xiamen University

Jiahuai Han - Xiamen University

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