Professor | 李阳 | 数字化转型顾问

	Upload Avatar (500 x 500)
Name	李阳
Contact Information	younglee@zju.edu.cn
Language ability	中文, 英文
Province	浙江

Upload Avatar (500 x 500)

Name

李阳

Contact Information

younglee@zju.edu.cn

Language ability

中文, 英文

Province

浙江

University/Lab Affiliation and Title	浙江大学
Faculty	Medical
Academic Background & Achievements	2008.9-2012.6 理学学士: 四川大学 2012.9-2018.12 理学博士: 浙江大学开发了基于CRISPR/Cas13系统的精准操纵RNA m1A修饰的分子工具阐明了转录因子KLF9在胃癌远端转移过程中的功能及分子机制利用TALEN技术定点敲除CIITA基因建立了低免疫原性的人胚胎干细胞系
Work Experience	2019.7-2021.12 - 四川师范大学 - 助理研究员 2022.1-2022.11 - 四川大学华西医院 - 助理研究员 2022.12至今 - 浙江大学医学院附属第四医院 - 特聘研究员

University/Lab Affiliation and Title

浙江大学

Faculty

Medical

Academic Background & Achievements

2008.9-2012.6 理学学士: 四川大学
2012.9-2018.12 理学博士: 浙江大学
开发了基于CRISPR/Cas13系统的精准操纵RNA m1A修饰的分子工具
阐明了转录因子KLF9在胃癌远端转移过程中的功能及分子机制
利用TALEN技术定点敲除CIITA基因建立了低免疫原性的人胚胎干细胞系

Work Experience

2019.7-2021.12 - 四川师范大学 - 助理研究员
2022.1-2022.11 - 四川大学华西医院 - 助理研究员
2022.12至今 - 浙江大学医学院附属第四医院 - 特聘研究员

Areas of Focus	RNA修饰在生理病理过程中的功能及其分子机制新型基因编辑工具的开发和优化
Publications	Inducible RNA targeting and N6-methyladenosine editing by a split-Cas13 architecture, Li, Y#,., Sun, Q#., Yang, Z#., Yuan, G., 2023 Long-read sequencing reveals the landscape of aberrant alternative splicing and novel therapeutic target in colorectal cancer, Sun, Q#., Han, Y#., He, J#., Ma, X., Ning, Q., Zhao, Q., Jin, Q., Yang, L., Li, S., Li, Y., Zhi, Q., Zheng, J., Dong, D., 2023 Programmable RNA N1-Methyladenosine Demethylation by a Cas13d-Directed Demethylase, Xie, S#., Jin, H#., Yang, F#., Zheng, H#., Chang, Y., Liao, Y., Zhang, Y., Zhou, T., Li, Y., 2021 KLF9 suppresses gastric cancer invasion and metastasis through transcriptional inhibition of MMP28, Li, Y#., Sun, Q#., Jiang, M., Li, S., Zhang, J., Xu, Z., Guo, D., Gu, T., Wang, B., Xiao, L., Zhou, T., Zhuo, W., 2019 FTO-mediated m6A modification of SOCS1 mRNA promotes the progression of diabetic kidney disease, Sun, Q#,., Geng, H#., Zhao, M#., Li, Y#., Chen, X., Sha, Q., Lai, P., Tang, D., Yang, D., Liang, J., Guo, M., 2022 Functional disruption of human leukocyte antigen II in human embryonic stem cell, Chen, H#., Li, Y#., Lin, X., Cui, D., Cui, C., Li, H., Xiao, L., 2015 Combining gene expression signature with clinical features for survival stratification of gastric cancer, Sun, Q#., Guo, D#., Li, S#., Xu, Y., Jiang, M., Li, Y., Duan, H., Zhuo, W., Liu, W., Zhu, S., Wang, L., Zhou, T., 2021 Prebiotics Inulin Metabolism by Lactic Acid Bacteria From Young Rabbits, Zhu, Y#,*., Yue, S#., Li, R#., Qiu, S., Xu, Z., Wu, Y., Yao, J., Zuo, Y., Li, K., Li, Y., 2021

Areas of Focus

RNA修饰在生理病理过程中的功能及其分子机制
新型基因编辑工具的开发和优化

Publications

Inducible RNA targeting and N6-methyladenosine editing by a split-Cas13 architecture, Li, Y#,*., Sun, Q#., Yang, Z#., Yuan, G*., 2023
Long-read sequencing reveals the landscape of aberrant alternative splicing and novel therapeutic target in colorectal cancer, Sun, Q#., Han, Y#., He, J#., Ma, X., Ning, Q., Zhao, Q., Jin, Q., Yang, L., Li, S., Li, Y., Zhi, Q*., Zheng, J*., Dong, D*., 2023
Programmable RNA N1-Methyladenosine Demethylation by a Cas13d-Directed Demethylase, Xie, S#., Jin, H#., Yang, F#., Zheng, H#., Chang, Y., Liao, Y., Zhang, Y*., Zhou, T*., Li, Y*., 2021
KLF9 suppresses gastric cancer invasion and metastasis through transcriptional inhibition of MMP28, Li, Y#., Sun, Q#., Jiang, M., Li, S., Zhang, J., Xu, Z., Guo, D., Gu, T., Wang, B., Xiao, L., Zhou, T*., Zhuo, W*., 2019
FTO-mediated m6A modification of SOCS1 mRNA promotes the progression of diabetic kidney disease, Sun, Q#,*., Geng, H#., Zhao, M#., Li, Y#., Chen, X., Sha, Q., Lai, P., Tang, D., Yang, D., Liang, J*., Guo, M*., 2022
Functional disruption of human leukocyte antigen II in human embryonic stem cell, Chen, H#., Li, Y#., Lin, X., Cui, D., Cui, C., Li, H., Xiao, L*., 2015
Combining gene expression signature with clinical features for survival stratification of gastric cancer, Sun, Q#., Guo, D#., Li, S#., Xu, Y., Jiang, M., Li, Y., Duan, H., Zhuo, W., Liu, W., Zhu, S., Wang, L*., Zhou, T*., 2021
Prebiotics Inulin Metabolism by Lactic Acid Bacteria From Young Rabbits, Zhu, Y#,*., Yue, S#., Li, R#., Qiu, S., Xu, Z., Wu, Y., Yao, J., Zuo, Y., Li, K., Li, Y., 2021

Rna修饰分子机制生理过程病理过程基因编辑 Crispr Cas13 Talen Klf9 胃癌

陈宝惠 - 浙江大学

杜丹 - 厦门大学

Area of Focus
Crispr | 肿瘤 | 免疫学 | 微生态 | 消化 | 电场 | 检测 | 治疗 | 分子机制 | 筛选

张进 - 浙江大学

View All

Personal Information

Academic Information

Research

联系我们

还未创建账户?

Personal Information

Academic Information

Research

联系我们