Areas of Focus
- 生理病理过程中的细胞应激反应
- 细胞应激反应的分子机制,包括炎症及相关疾病
Work Experience
- 1990-1992 研究员,美国德克萨斯大学西南医学中心
- 1992-1993 研究助理,美国斯克里普斯研究所
- 1993-1996 助理成员,美国斯克里普斯研究所
- 1996-2004 副教授,美国斯克里普斯研究所
- 2004-2007 教授,美国斯克里普斯研究所
- 2002-2007 厦门大学兼职教授
- 2007至今 厦门大学教授
- 厦门大学医学与生命科学学部主任
- 细胞应激生物学国家重点实验室主任
- 厦门大学实验动物中心主任
- 厦门大学副校长
Academic Background & Achievements
- 1978-1982 生物化学学士学位:北京大学
- 1982-1985 蛋白质化学硕士学位:北京大学
- 1985-1990 分子生物学博士学位:布鲁塞尔大学
- 2013 中国科学院院士
Publications
- Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion, He WT, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J, 2015
- Group-DIA: analyzing multiple data-independent acquisition mass spectrometry data files, Li Y, Zhong CQ, Xu X, Cai S, Wu X, Zhang Y, Chen J, Shi J, Lin S, Han J, 2015
- Ppm1b negatively regulates necroptosis through dephosphorylating Rip3, Chen W, Wu J, Li L, Zhang Z, Ren J, Liang Y, Chen F, Yang C, Zhou Z, Sean Su S, Zheng X, Zhang Z, Zhong CQ, Wan H, Xiao M, Lin X, Feng XH, Han J, 2015
- RIP1/RIP3 Binding to HSV-1 ICP6 Initiates Necroptosis to Restrict Virus Propagation in Mice, Huang Z, Wu SQ, Liang Y, Zhou X, Chen W, Li L, Wu J, Zhuang Q, Chen C, Li J, Zhong CQ, Xia W, Zhou R, Zheng C, Han J, 2015
- Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death, Chen X, Li W, Ren J, Huang D, He WT, Song Y, Yang C, Li W, Zheng X, Chen P, Han J, 2013
- RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis, Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J, 2009
- PRAK is essential for ras-induced senescence and tumor suppression, Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong MQ, Frangou CG, Yates JR, 3rd, Wright PE, Han J, 2007
- Involvement of microRNA in AU-rich element-mediated mRNA instability, Jing Q, Huang S, Guth S, Zarubin T, Motoyama A, Chen J, DiPadova F, Lin SC, Gram H, Han J, 2005
- MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha, Ge B, Gram H, DiPadova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J, 2002
- Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation, Han J, Jiang Y, Li Z, Kravchenko VV, Ulevitch RJ, 1997
- A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells, Han J, Lee JD, Bibbs L, Ulevitch RJ, 1994
Awards
- 2013: 中国科学院院士