Professor | Lige Leng | Asia Growth Partners

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Name	Lige Leng
Contact Information	nlenglige@xmu.edu.cn
Language ability	Chinese, English
Province	Fujian

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Name

Lige Leng

Contact Information

nlenglige@xmu.edu.cn

Language ability

Chinese, English

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Medical
Academic Background & Achievements	2010-2013 Medical Doctorate: Capital Medical University/Beijing Neurosurgical Institute 2003-2010 Bachelor and Master in Clinical Medicine/Surgery: Capital Medical University
Work Experience	2023.9-present - Xiamen University School of Medicine - Professor 2019.8-2023.8 - Xiamen University School of Medicine - Associate Professor 2016.1-2019.7 - Xiamen University School of Medicine - Assistant Professor 2013.9-2015.12 - Second Military Medical University/PLA Navy General Hospital - Postdoctoral Researcher
Awards	Changjiang Young Scholar (2023): Ministry of Education Second Prize for Excellent Academic Papers in Natural Science of Fujian Province (2020) Second Prize in the First Anatomy Teaching Competition of Fujian Province (2021) Third Prize in the Second Teaching Competition of Fujian Province (2023) Third Prize in the First Rising Sun Cup Teaching Competition of the Chinese Society of Anatomy (2023)

University/Lab Affiliation and Title

Xiamen University

Faculty

Medical

Academic Background & Achievements

2010-2013 Medical Doctorate: Capital Medical University/Beijing Neurosurgical Institute
2003-2010 Bachelor and Master in Clinical Medicine/Surgery: Capital Medical University

Work Experience

2023.9-present - Xiamen University School of Medicine - Professor
2019.8-2023.8 - Xiamen University School of Medicine - Associate Professor
2016.1-2019.7 - Xiamen University School of Medicine - Assistant Professor
2013.9-2015.12 - Second Military Medical University/PLA Navy General Hospital - Postdoctoral Researcher

Awards

Changjiang Young Scholar (2023): Ministry of Education
Second Prize for Excellent Academic Papers in Natural Science of Fujian Province (2020)
Second Prize in the First Anatomy Teaching Competition of Fujian Province (2021)
Third Prize in the Second Teaching Competition of Fujian Province (2023)
Third Prize in the First Rising Sun Cup Teaching Competition of the Chinese Society of Anatomy (2023)

Areas of Focus	Pathogenic mechanisms of neurodegenerative diseases Role and mechanism of microglial metabolic mode conversion in AD pathogenesis Metabolic abnormalities of astrocytes under stress and their systemic metabolic regulation Interrelationship between hypothalamic energy metabolism changes and aging Screening of early diagnostic markers and targeted drugs for AD
Publications	Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance, Lige Leng, Ziqi Yuan, Ruiyuan Pan, Xiao Su, Han Wang, Jin Xue, Kai Zhuang, Ju Gao, Zhenlei Chen, Hui Lin, Wenting Xie, Huifang Li, Zhenyi Chen, Keke Ren, Xiao Zhang, Wenting Wang, Zi-Bing Jin, Shengxi Wu, Xinglong Wang, Zengqiang Yuan, Huaxi Xu, Hei-Man Chow, Jie Zhang, 2022 Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation, Leng Lige, Zhuang Kai, Liu Zeyue, Huang Changquan, Gao Yuehong, Chen Guimiao, Lin Hui, Hu Yu, Wu Di, Shi Meng, Xie Wenting, Sun Hao, Shao Zhicheng, Li Huifang, Zhang Kunkun, Mo Wei, Huang Timothy Y, Xue Maoqiang, Yuan Zengqiang, Zhang Xia, Bu Guojun, Xu Huaxi, Xu Qi, Zhang Jie, 2018 Hypothalamic Menin regulates systemic aging and cognitive decline, Lige Leng, Ziqi Yuan, Xiao Su, Zhenlei Chen, Shangchen Yang, Meiqin Chen, Kai Zhuang, Hui Lin, Hao Sun, Huifang Li, Maoqiang Xue, Jun Xu, Jingqi Yan, Zhenyi Chen, Tifei Yuan, Jie Zhang, 2023 Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression, Zhuang Kai, Huang Changquan, Leng Lige, Zheng Honghua, Gao Yuehong, Chen Guimiao, Ji Zhilin, Sun Hao, Hu Yu, Wu Di, Shi Meng, Li Huifang, Zhao Yingjun, Zhang Yunwu, Xue Maoqiang, Bu Guojun, Huang Timothy Y, Xu Huaxi, Zhang Jie, 2018 Brain Energy Metabolism: Astrocytes in Neurodegenerative Diseases, Zhenlei Chen, Ziqi Yuan, Shangchen Yang, Yufei Zhu, Maoqiang Xue, Jie Zhang, Lige Leng, 2022 Application of antidepressants in depression: A systematic review and meta-analysis, Yuan Ziqi, Chen Zhenlei, Xue Maoqiang, Zhang Jie, Leng Lige, 2020

Areas of Focus

Pathogenic mechanisms of neurodegenerative diseases
Role and mechanism of microglial metabolic mode conversion in AD pathogenesis
Metabolic abnormalities of astrocytes under stress and their systemic metabolic regulation
Interrelationship between hypothalamic energy metabolism changes and aging
Screening of early diagnostic markers and targeted drugs for AD

Publications

Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance, Lige Leng, Ziqi Yuan, Ruiyuan Pan, Xiao Su, Han Wang, Jin Xue, Kai Zhuang, Ju Gao, Zhenlei Chen, Hui Lin, Wenting Xie, Huifang Li, Zhenyi Chen, Keke Ren, Xiao Zhang, Wenting Wang, Zi-Bing Jin, Shengxi Wu, Xinglong Wang, Zengqiang Yuan, Huaxi Xu, Hei-Man Chow, Jie Zhang, 2022
Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation, Leng Lige, Zhuang Kai, Liu Zeyue, Huang Changquan, Gao Yuehong, Chen Guimiao, Lin Hui, Hu Yu, Wu Di, Shi Meng, Xie Wenting, Sun Hao, Shao Zhicheng, Li Huifang, Zhang Kunkun, Mo Wei, Huang Timothy Y, Xue Maoqiang, Yuan Zengqiang, Zhang Xia, Bu Guojun, Xu Huaxi, Xu Qi, Zhang Jie, 2018
Hypothalamic Menin regulates systemic aging and cognitive decline, Lige Leng, Ziqi Yuan, Xiao Su, Zhenlei Chen, Shangchen Yang, Meiqin Chen, Kai Zhuang, Hui Lin, Hao Sun, Huifang Li, Maoqiang Xue, Jun Xu, Jingqi Yan, Zhenyi Chen, Tifei Yuan, Jie Zhang, 2023
Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression, Zhuang Kai, Huang Changquan, Leng Lige, Zheng Honghua, Gao Yuehong, Chen Guimiao, Ji Zhilin, Sun Hao, Hu Yu, Wu Di, Shi Meng, Li Huifang, Zhao Yingjun, Zhang Yunwu, Xue Maoqiang, Bu Guojun, Huang Timothy Y, Xu Huaxi, Zhang Jie, 2018
Brain Energy Metabolism: Astrocytes in Neurodegenerative Diseases, Zhenlei Chen, Ziqi Yuan, Shangchen Yang, Yufei Zhu, Maoqiang Xue, Jie Zhang, Lige Leng, 2022
Application of antidepressants in depression: A systematic review and meta-analysis, Yuan Ziqi, Chen Zhenlei, Xue Maoqiang, Zhang Jie, Leng Lige, 2020

Neurodegenerative Diseases Pathogenic Mechanisms Microglial Metabolism Astrocytes Stress Hypothalamus Aging Diagnostic Markers Targeted Drugs Alzheimer'S Disease

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