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Lige Leng
Medical School
Xiamen University
Fujian
Language: Chinese, English
Neurodegenerative Diseases
Pathogenic Mechanisms
Microglial Metabolism
Astrocytes
Stress
Hypothalamus
Aging
Diagnostic Markers
Targeted Drugs
Alzheimer'S Disease
Areas of Focus
- Pathogenic mechanisms of neurodegenerative diseases
- Role and mechanism of microglial metabolic mode conversion in AD pathogenesis
- Metabolic abnormalities of astrocytes under stress and their systemic metabolic regulation
- Interrelationship between hypothalamic energy metabolism changes and aging
- Screening of early diagnostic markers and targeted drugs for AD
Work Experience
- 2023.9-present - Xiamen University School of Medicine - Professor
- 2019.8-2023.8 - Xiamen University School of Medicine - Associate Professor
- 2016.1-2019.7 - Xiamen University School of Medicine - Assistant Professor
- 2013.9-2015.12 - Second Military Medical University/PLA Navy General Hospital - Postdoctoral Researcher
Academic Background & Achievements
- 2010-2013 Medical Doctorate: Capital Medical University/Beijing Neurosurgical Institute
- 2003-2010 Bachelor and Master in Clinical Medicine/Surgery: Capital Medical University
Publications
- Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance, Lige Leng, Ziqi Yuan, Ruiyuan Pan, Xiao Su, Han Wang, Jin Xue, Kai Zhuang, Ju Gao, Zhenlei Chen, Hui Lin, Wenting Xie, Huifang Li, Zhenyi Chen, Keke Ren, Xiao Zhang, Wenting Wang, Zi-Bing Jin, Shengxi Wu, Xinglong Wang, Zengqiang Yuan, Huaxi Xu, Hei-Man Chow, Jie Zhang, 2022
- Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation, Leng Lige, Zhuang Kai, Liu Zeyue, Huang Changquan, Gao Yuehong, Chen Guimiao, Lin Hui, Hu Yu, Wu Di, Shi Meng, Xie Wenting, Sun Hao, Shao Zhicheng, Li Huifang, Zhang Kunkun, Mo Wei, Huang Timothy Y, Xue Maoqiang, Yuan Zengqiang, Zhang Xia, Bu Guojun, Xu Huaxi, Xu Qi, Zhang Jie, 2018
- Hypothalamic Menin regulates systemic aging and cognitive decline, Lige Leng, Ziqi Yuan, Xiao Su, Zhenlei Chen, Shangchen Yang, Meiqin Chen, Kai Zhuang, Hui Lin, Hao Sun, Huifang Li, Maoqiang Xue, Jun Xu, Jingqi Yan, Zhenyi Chen, Tifei Yuan, Jie Zhang, 2023
- Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression, Zhuang Kai, Huang Changquan, Leng Lige, Zheng Honghua, Gao Yuehong, Chen Guimiao, Ji Zhilin, Sun Hao, Hu Yu, Wu Di, Shi Meng, Li Huifang, Zhao Yingjun, Zhang Yunwu, Xue Maoqiang, Bu Guojun, Huang Timothy Y, Xu Huaxi, Zhang Jie, 2018
- Brain Energy Metabolism: Astrocytes in Neurodegenerative Diseases, Zhenlei Chen, Ziqi Yuan, Shangchen Yang, Yufei Zhu, Maoqiang Xue, Jie Zhang, Lige Leng, 2022
- Application of antidepressants in depression: A systematic review and meta-analysis, Yuan Ziqi, Chen Zhenlei, Xue Maoqiang, Zhang Jie, Leng Lige, 2020
Awards
- Changjiang Young Scholar (2023): Ministry of Education
- Second Prize for Excellent Academic Papers in Natural Science of Fujian Province (2020)
- Second Prize in the First Anatomy Teaching Competition of Fujian Province (2021)
- Third Prize in the Second Teaching Competition of Fujian Province (2023)
- Third Prize in the First Rising Sun Cup Teaching Competition of the Chinese Society of Anatomy (2023)
