Upload Avatar (500 x 500)
Mingyu Li
Medical School
Xiamen University
Fujian
Language: Chinese, English
Pancreatic Α Cells
Glucagon Signaling
Β Cell Regeneration
Diabetes Models
Anti-Diabetic Drugs
Disease Models
Drug Screening
Marine Drugs
Crispr
Genome Editing
Areas of Focus
- Molecular regulation mechanisms of pancreatic α cells and glucagon signaling pathways
- Research and development of drugs promoting pancreatic β cell regeneration
- Construction of diabetes models and screening of anti-diabetic drugs
- Establishment of disease models and drug screening
- Screening and mechanism of marine drugs
- CRISPR genome editing technology
Work Experience
- 2010-2011 - Third Institute of Oceanography, State Oceanic Administration - Assistant Researcher
- 2011-2016 - Vanderbilt University - Postdoctoral Researcher
- 2016-present - Xiamen University, School of Pharmacy - Associate Professor
Academic Background & Achievements
- 1999-2003 Bachelor: Ocean University of China (Biotechnology)
- 2003-2006 Master: Ocean University of China (Cell Biology)
- 2006-2010 PhD: Ocean University of China (Pharmaceutical Chemistry)
- Published over 40 articles in international journals
- Cited over 1500 times
Publications
- Artemether and aspterric acid induce pancreatic α cells to transdifferentiate into β cells in zebrafish., Jia J., Kang Q., Liu S., Song Y., Wong F.S., Qiu Y., Li M., 2022
- Knockout of Nur77 leads to amino acid, lipid and glucose metabolism disorders in zebrafish., Xu, Y., Tian, J., Kang, Q., Yuan, H., Liu, C., Li, Z., Liu, J., Li M., 2022
- Linear Polyketides Produced by Co-Culture of Penicillium crustosum and Penicillium fellutanum., Yu, G., Sun, P., Aierken, R., Sun, C., Zhang, Z., Che, Q., Zhang, G., Zhu, T., Gu, Q., Li, M., Li, D., 2022
- Instantaneous Phosphatidylcholine spatial specific regulation induced by formononetin revealed by DESI-MSI., Tie, C., Zhu, C., Jin, Y., Liang, H., Li, M., Tian, J., Wu, C., 2022
- New Sorbicillinoids with Tea Pathogenic Fungus Inhibitory Effect from Marine-Derived Fungus Hypocrea jecorina H8., Liu, S.-Z.; Xu, G.-X.; He, F.-M.; Zhang, W.-B.; Wu, Z.; Li, M.-Y.; Tang, X.-X.; Qiu, Y.-K., 2022
- Integrated Metabolomics and Lipidomics Analysis Reveal Remodeling of Lipid Metabolism and Amino Acid Metabolism in Glucagon Receptor-Deficient Zebrafish., Bai, X., Jia, J., Kang, Q., Fu, Y., Zhou, Y., Zhong, Y., Zhang, C., Li, M., 2021
- Penipyrols C−G and methyl-penipyrol A, α-Pyrone Polyketides from the Mangrove Derived Fungus Penicillium sp. HDN-11-131., Wang, L., Shi, Y., Che, Q., Zhu, T., Zhang, G., Zhang X.K., Li, M., Li, D., 2021
- IGF-2 mRNA binding protein 2 regulates primordial germ cell development in zebrafish., Li, M., Rong, X., Lu, L., Li, Y., Yao, K., Ge, W., Duan, C., 2021
- Impact of macroporous silica nanoparticles at sub-50nm on bio-behaviors and biosafety in drug-resistant cancer models., Xu, W., Zhou, M., Guo, Z., Lin, S., Li, M., Kang, Q., Xu, Y., Zhang, X., Xie, J., 2021
- Staprexanthones, Xanthone-Type Stimulators of Pancreatic β-cell Proliferation from a Mangrove Endophytic Fungus., Gan Q., Lin C., Lu C., Chang Y., Che Q., Zhang G., Zhu T., Gu Q., Wu Z., Li M., Li D., 2020
- Global Transcriptomic Analysis of Zebrafish Glucagon Receptor Mutant Reveals Its Regulated Metabolic Network., Kang, Q., Hu, M., Jia, J., Bai, X., Liu, C., Wu, Z., Chen, W., Li, M., 2020
- Characterization of Insulin and Glucagon Genes and Their Producing Endocrine Cells From Pygmy Sperm Whale (Kogia breviceps)., Zhao, L., Wang, L., Aierken, R., Wang, W., Wang, X., Li, M., 2020
- Cancer-targeted and intracellular delivery of Bcl-2-converting peptide with functional macroporous silica nanoparticles for biosafe treatment., Wu, Y., Ge, P., Xu, W., Li, M., Kang, Q., Zhang, X., Xie, J., 2020
- Enhanced cancer therapy of celastrol in vitro and in vivo by smart dendrimers delivery with specificity and biosafety., Ge, P., Niu, B., Wu, Y., Xu, W., Li, M., Sun, H., Zhou, H., Zhang, X., Xie, J., 2020
- Two new compounds from a mangrove sediment-derived fungus Penicillium polonicum H175., Liu, S. Z., Tang, X. X., He, F. M., Jia, J. X., Hu, H., Xie, B. Y., Li, M. Y., Qiu, Y. K., 2020
- Construction of a transgenic zebrafish model with nuclear-specific expression of mCherry in pancreatic α cells., Lin, C., Jia, J., Kang, Q., Wu, Z., Li, M., 2020
- SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway., Chen, Z., Zhang, D., Yan, S., Hu, C., Huang, Z., Li, Z., Peng, S., Li, X., Zhu, Y., Yu, H., Lian, B., Kang, Q., Li, M., Zeng, Z., Zhang, X. K., Su, Y., 2019
- In vivo screening of flavonoids promoting pancreatic β-cell proliferation., Wang, C., Lin, C., Wu, Z., Li, M., 2019
- Interrupted Glucagon Signaling Reveals Hepatic alpha Cell Axis and Role for L-Glutamine in alpha Cell Proliferation., Dean, E. D., Li, M., Prasad, N., Wisniewski, S. N., Von Deylen, A., Spaeth, J., Maddison, L., Botros, A., Sedgeman, L. R., Bozadjieva, N., Ilkayeva, O., Coldren, A., Poffenberger, G., Shostak, A., Semich, M. C., Aamodt, K. I., Phillips, N., Yan, H., Bernal-Mizrachi, E., Corbin, J. D., Vickers, K. C., Levy, S. E., Dai, C., Newgard, C., Gu, W., Stein, R., Chen, W., Powers, A. C., 2017
- Modulation of the Nur77-Bcl-2 apoptotic pathway by p38alpha MAPK., Liu, J., Wang, G. H., Duan, Y. H., Dai, Y., Bao, Y., Hu, M., Zhou, Y. Q., Li, M., Jiang, F., Zhou, H., Yao, X. S., Zhang, X. K., 2017
- FGF1 Mediates Overnutrition-Induced Compensatory beta-Cell Differentiation., Li, M., Page-McCaw, P., Chen, W., 2016
- Zebrafish Genome Engineering Using the CRISPR-Cas9 System., Li, M., Zhao, L., Page-McCaw, P. S., Chen, W., 2016
- Glucagon receptor inactivation leads to alpha-cell hyperplasia in zebrafish., Li, M., Dean, E. D., Zhao, L., Nicholson, W. E., Powers, A. C., Chen, W., 2015
- Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs., Yin, L., Maddison, L. A., Li, M., Kara, N., LaFave, M. C., Varshney, G. K., Burgess, S. M., Patton, J. G., Chen, W., 2015
- High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9., Varshney, G. K., Pei, W., LaFave, M. C., Idol, J., Xu, L., Gallardo, V., Carrington, B., Bishop, K., Jones, M., Li, M., Harper, U., Huang, S. C., Prakash, A., Chen, W., Sood, R., Ledin, J., Burgess, S. M., 2015
- Genome sequencing of the perciform fish Larimichthys crocea provides insights into molecular and genetic mechanisms of stress adaptation., Ao, J., Mu, Y., Xiang, L. X., Fan, D., Feng, M., Zhang, S., Shi, Q., Zhu, L. Y., Li, T., Ding, Y., Nie, L., Li, Q., Dong, W. R., Jiang, L., Sun, B., Zhang, X., Li, M., Zhang, H. Q., Xie, S., Zhu, Y., Jiang, X., Wang, X., Mu, P., Chen, W., Yue, Z., Wang, Z., Wang, J., Shao, J. Z., Chen, X., 2015
- Overnutrition induces beta-cell differentiation through prolonged activation of beta-cells in zebrafish larvae., Li, M., Maddison, L. A., Page-McCaw, P., Chen, W., 2014
- Identification of cathepsin B from large yellow croaker (Pseudosciaena crocea) and its role in the processing of MHC class II-associated invariant chain., Li, M., Li, Q., Yang, Z., Hu, G., Li, T., Chen, X., Ao, J., 2014
- De novo characterization of the spleen transcriptome of the large yellow croaker (Pseudosciaena crocea) and analysis of the immune relevant genes and pathways involved in the antiviral response., Mu, Y., Li, M., Ding, F., Ding, Y., Ao, J., Hu, S., Chen, X., 2014
- Conditional gene-trap mutagenesis in zebrafish., Maddison, L. A., Li, M., Chen, W., 2014
- Targeted overexpression of CKI-insensitive cyclin-dependent kinase 4 increases functional beta-cell number through enhanced self-replication in zebrafish., Li, M., Maddison, L. A., Crees, Z., Chen, W., 2013
- Molecular cloning and characterization of caspase-3 in large yellow croaker (Pseudosciaena crocea)., Li, M., Ding, Y., Mu, Y., Ao, J., Chen, X., 2011
- Characterization of large yellow croaker (Pseudosciaena crocea) beta-actin promoter supports beta-actin gene as an internal control for gene expression modulation and its potential application in transgenic studies in fish., Xiao, X., Li, M., Wang, K., Qin, Q., Chen, X., 2011
- Structural, gene expression, and functional analysis of the fugu (Takifugu rubripes) insulin-like growth factor binding protein-4 gene., Li, M., Li, Y., Lu, L., Wang, X., Gong, Q., Duan, C., 2009
- Purification and characterization of phenoloxidase from Octopus ocellatus., Fan, T., Li, M., Wang, J., Yang, L., Cong, R., 2009
- Cloning of proliferating cell nuclear antigen gene from the dinoflagellate Prorocentrum donghaiense and monitoring its expression profiles by real-time RT-PCR., Zhao, L., Mi, T., Zhen, Y., Li, M., He, S., Sun, J., Yu, Z., 2009
- Molecular and functional characterization of two distinct IGF binding protein-6 genes in zebrafish., Wang, X., Lu, L., Li, Y., Li, M., Chen, C., Feng, Q., Zhang, C., Duan, C., 2009
