2009-2012 Master's in Chemical Biology: Xiamen University
2005-2009 Bachelor's in Biotechnology: Northwest A&F University
2023-present - Xiamen University - Associate Professor
2019-2023 - Xiamen University - Assistant Professor
2016-2019 - Xiamen University - Postdoctoral Researcher
2013-2014 - Sanford-Burnham Medical Research Institute, USA - Visiting Scholar
Research
Molecular mechanisms and therapeutic targets of neurological diseases
β2-microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice., Zhao Y, Zheng Q, Hong Y, Gao Y, Hu J, Lang M, Zhang H, Zhou Y, Luo H, Zhang X, Sun H, Yan XX, Huang TY, Wang YJ, Xu H, Liu C, Wang X*., 2023
β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function., Gao Y, Hong Y, Huang L, Zheng S, Zhang H, Wang S, Yao Y, Zhao Y, Zhu L, Xu Q, Chai X, Zeng Y, Zeng Y, Zheng L, Zhou Y, Luo H, Zhang X, Zhang H, Zhou Y, Fu G, Sun H, Huang TY, Zheng Q, Xu H, Wang X*., 2023
Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice., Meng J#, Han L#, Zheng N, Wang T, Xu H, Jiang Y, Wang Z, Liu Z, Zheng Q, Zhang X, Luo H, Can D, Lu J, Xu H, Zhang Y-W*., 2022
Metabolic reprogramming in astrocytes results in neuronal dysfunction in intellectual disability., Zhang H#, Zheng Q#, Guo T#, Zhang S#, Zheng S, Wang R, Deng Q, Yang G, Zhang S, Tang L, Qi Q, Zhu L, Zhang X-F, Luo H, Zhang X, Sun H, Gao Y, Zhang H, Zhou Y, Han A, Zhang C-S, Xu H, Wang X*., 2022
USP25 inhibition ameliorates Alzheimer’s pathology through regulating APP processing and Aβ generation., Zheng Q#, Song B#, Li G#, Cai F#, Wu M, Zhao Y, Jiang L, Guo T, Shen M, Hou H, Zhou Y, Zhao Y, Di A, Zhang L, Zeng F, Zhang X-F, Luo H, Zhang X, Zhang H, Zeng Z, Huang T, Dong C, Qing H, Zhang Y, Zhang Q, Wang X, Wu Y, Xu H*, Song W*, Wang X*., 2022
SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate., Zhang H#, Hong Y#, Yang W, Wang R, Yao T, Wang J, Liu K, Yuan H, Xu C, Zhou Y, Li G, Zhang L, Luo H, Zhang X, Du D, Sun H, Zheng Q, Zhang Y-W, Zhao Y, Zhou Y, Xu H, Wang X*., 2021
Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25., Zheng Q#, Li G#, Wang S, Zhou Y, Liu K, Gao Y, Zhou Y, Zheng L, Zhu L, Deng Q, Wu M, Di A, Zhang L, Zhao Y, Zhang H, Sun H, Dong C, Xu H, Wang X*., 2021
Overexpression of Human SNX27 Enhances Learning and Memory Through Modulating Synaptic Plasticity in Mice., Huo Y#, Gao Y#, Zheng Q, Zhao D, Guo T, Zhang S, Zeng Y, Cheng Y, Gu H, Zhang L, Zhu B, Luo H, Zhang X, Zhou Y, Zhang Y-W, Sun H, Xu H, Wang X*., 2020
The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability., Zeng F#, Ma X#, Zhu L#, Xu Q, Zeng Y, Gao Y, Li G, Guo T, Zhang H, Tang X, Wang Z, Ye Z, Zheng L, Zhang H, Zheng Q, Li K, Lu J, Qi X, Luo H, Zhang X, Wang Z, Zhou Y, Yao Y, Ke R, Zhou Y, Liu Y, Sun H, Huang T, Shao Z, Xu H, Wang X*., 2019
Snx27 Deletion Promotes Recovery From Spinal Cord Injury by Neuroprotection and Reduces Macrophage/Microglia Proliferation., Zeng Y, Wang N, Guo T, Zheng Q, Wang S, Wu S, Li X, Wu J, Chen Z, Xu H, Wang X*, Lin B*., 2018
Inhibition of PKCdelta reduces amyloid-beta levels and reverses Alzheimer disease phenotypes., Du Y#, Zhao Y#, Li C#, Zheng Q, Tian J, Li Z, Huang T, Zhang W*, Xu H., 2018
The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death., Zheng Q, Zheng X, Zhang L, Luo H, Qian L, Fu X, Liu Y, Gao Y, Niu M, Meng J, Zhang M, Bu G, Xu H, Zhang Y-W*., 2017
Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases., Zheng Q, Huang T, Zhang L, Zhou Y, Luo H, Xu H, Wang X*., 2016
SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis., Wang X*, Zhou Y, Wang J, Tseng I C, Huang T, Zhao Y, Zheng Q, Gao Y, Luo H, Zhang X, Bu G, Hong W, Xu H*., 2016
Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis., Zhao Y, Tseng I C, Heyser C J, Rockenstein E, Mante M, Adame A, Zheng Q, Huang T, Wang X, Arslan P E, Chakrabarty P, Wu C, Bu G, Mobley W C, Zhang Y-W, St George-Hyslop P, Masliah E, Fraser P, Xu H*., 2015
Role of copper and the copper-related protein CUTA in mediating APP processing and Abeta generation., Hou P, Liu G, Zhao Y, Shi Z, Zheng Q, Bu G, Xu H, Zhang Y-W*., 2015
Sorting nexin 27 regulates Abeta production through modulating gamma-secretase activity., Wang X, Huang T, Zhao Y, Zheng Q, Thompson R C, Bu G, Zhang Y-W, Hong W, Xu H*., 2014
Ferritin light chain interacts with PEN-2 and affects gamma-secretase activity., Li X#, Liu Y#, Zheng Q#, Yao G, Cheng P, Bu G, Xu H, Zhang Y-W*., 2013
