Upload Avatar (500 x 500)
Baoxue Yang
Basic Medical Sciences
Peking University
Beijing
Language: Chinese, English
Diuretics
Renal Injury
Repair Mechanisms
Polycystic Kidney Disease
Drug Development
Urea Transporters
Aquaporins
Molecular Biology
Cell Biology
Pharmacology
Areas of Focus
- Cardiovascular Pharmacology
- Renal Physiology
Work Experience
- 1994-1997 - Postdoctoral Training at UCSF Cardiovascular Research Institute
- 1997-2003 - Assistant Researcher at UCSF Cardiovascular Research Institute
- 2003-2007 - Assistant Professor at UCSF Medical Department
- 2007-present - Professor at Peking University, School of Basic Medical Sciences, Department of Pharmacology
Academic Background & Achievements
- 1984 - Bachelor of Medicine: Norman Bethune College of Medicine
- 1987 - Master of Medical Genetics: Norman Bethune College of Medicine
- 1993 - PhD in Immunology: Norman Bethune College of Medicine
- Published 117 SCI papers, entered Elsevier's list of most influential Chinese scholars for 2014, 2015, and 2016
- Filed 11 patents
Publications
- Aquaporin-3 deletion in mice results in renal collecting duct abnormalities and worsens ischemia-reperfusion injury, Lei L., W. Wang, Y. Jia, L. Su, H. Zhou, A. S. Verkman, and B. Yang, 2017
- Generation and phenotypic analysis of mice lacking all urea transporters, Jiang T., Y. Li, A. T. Layton, W. Wang, Y. Sun, M. Li, H. Zhou, and B. Yang, 2017
- Low molecular weight fucoidan protects renal tubular cells from injury induced by albumin overload, Jia Y., Y. Sun, L. Weng, Y. Li, Q. Zhang, H. Zhou, and B. Yang, 2016
- Functional inhibition of urea transporter UT-B enhances endothelial-dependent vasodilation and lowers blood pressure via L-arginine-endothelial nitric oxide synthase-nitric oxide pathway, Sun Y., C. Lau, Y. Jia, Y. Li, W. Wang, J. Ran, F. Li, Y. Huang, H. Zhou, and B. Yang, 2016
- Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling, Wang W., F. Li, Y. Sun, L. Lei, H. Zhou, T. Lei, Y. Xia, A. S. Verkman, and B. Yang, 2015
- Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress, Zhong D., H. Wang, M. Liu, X. Li, M. Huang, H. Zhou, S. Lin, Z. Lin, and B. Yang, 2015
- Activation of protein kinase C-α and Src increases urea transporter A1 α-2,6 sialylation, Li X., B. Yang, M. Chen, J. Klein, Jeff. Sands, and G. Chen, 2015
- Developing hypothetical inhibition mechanism of novel urea transporter B inhibitor, Li M., W.I. Tou, H. Zhou, F. Li, H. Ren, C.Y. Chen, and B. Yang, 2014
- mPGES-2 deletion remarkably enhances liver injury in streptozotocin-treated mouse via induction of GLUT2, Sun Y., Z. Jia, G. Yang, Y. Kakizo, M. Liu, K.Yang, Y. Liu, B. Yang and T. Yang, 2014
- A novel small-molecule thienoquinolin urea transporter inhibitor acts as a potential diuretic, Li F., T. Lei, J. Zhu, W. Wang, Y. Sun, J. Chen, Z. Dong, H. Zhou and B. Yang, 2013
Awards
- Funded by American NIH, PKD, AHA funds, China's 985 Project Fund, 'Major New Drug Creation' National Science and Technology Major Project Fund, National Natural Science Foundation of China, Doctoral Fund of Ministry of Education, International Science and Technology Cooperation Projects of Ministry of Science and Technology, Program for Innovative Research Team in University of Ministry of Education
