Upload Avatar (500 x 500)
Mingming Hu
Immunology and Metabolion
Wuhan University
Hubei
Language: Chinese, English
Viral
Immune
Tumor
Signaling
Metabolic
Regulation
Mechanisms
Immunology
Pathways
Response
Areas of Focus
- Viral Immunology
- Tumor Immunology: Signaling Mechanisms and Metabolic Regulation
Work Experience
- 2016.10-2019.8 Wuhan University Medical Research Institute, Distinguished Associate Researcher
- 2018.4-present National Key Laboratory of Virology, PI
- 2019.9-present Wuhan University Medical Research Institute, Professor and Doctoral Supervisor
- 2020.1-present Center for Frontier Science of Immunology and Metabolism, PI
- 2020.7-present Zhongnan Hospital of Wuhan University, Distinguished Professor
- 2022.4-present Wuhan University Taikang Life Medical Center, PI
Academic Background & Achievements
- 2007-2011 Bachelor: Wuhan University, School of Life Sciences
- 2011-2016 PhD: Wuhan University, School of Life Sciences
Publications
- Endocytosis triggers V-ATPase-SYK-mediated priming of cGAS activation and innate immune response, Yang, Y.L., Cao, L.B., He, W.R., Zhong, L., Guo, Y., Yang, Q., Shu, H.B., and Hu, M.M.*, 2022
- Estrogen receptor a-mediated signaling inhibits type I interferon response to promote breast cancer, Cao, L.B., Ruan Z.L., Yang Y.L., Zhang N.C., Gao, C., Cai, C.G., Zhang J., Hu, M.M.*, and Shu H.B.*, 2023
- beta-adrenoreceptor-triggered PKA activation negatively regulates the innate antiviral response, Guo, Y., Zhang, X.N., Su, S., Ruan, Z.L., Hu, M.M.*, and Shu, H.B.*, 2023
- Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone, Su, S., Hua, D., Li, J.P., Zhang, X.N., Bai, L., Cao, L.B., Guo, Y., Zhang, M., Dong, J.Z., Liang, X.W., Lan, K., Hu, M.M.*, and Shu, H.B.*, 2022
- VRK2 is involved in innate antiviral response by promoting mitostress-induced mtDNA release, He W.R., Cao L.B., Yang Y.L., Hua D., Hu M.M.* and Shu H.B.*, 2021
- Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases, Hu M.M.* and Shu H.B.*, 2020
- Virus-induced accumulation of intracellular bile acids activates the TGR5-b-arrestin-SRC axis to enable innate antiviral immunity, Hu M.M.*, He W.R., Gao P., Yang Q., He K., Cao L.B., Li S., Feng Y.Q. and Shu H.B.*, 2019
- Cytoplasmic mechanisms of recognition and defense of microbial nucleic acids, Hu M.M.* and Shu H.B.*, 2018
- TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses, Yang, Q., Liu, T.T., Lin, H., Zhang, M., Wei, J., Luo, W.W., Hu, Y.H., Zhong, B., Hu, M.M.*, and Shu, H.B.*, 2017
- Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5, Hu, M.M., Liao, C.Y., Yang, Q., Xie, X.Q., and Shu. H.B.*, 2017
- Multifaceted roles of TRIM38 in innate immune and inflammatory responses, Hu, M.M. and Shu H.B., 2017
- Sumoylation promotes the stability of the DNA sensor cGAS and the adaptor STING to regulate the kinetics of response to DNA virus, Hu, M.M., Yang, Q., Zhang, J., Liu, S.M., Zhang, Y., Lin, H., Huang, Z.F., Wang, Y.Y., Zhang, X.D., Zhong, B., and Shu, H.B., 2016
- TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms, Hu, M.M., Yang, Q., Xie, X.Q., Liao, C.Y., Lin, H., Liu, T.T., and Shu, H.B.*, 2015
- TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3, Hu, M.M., Yang, Q., Zhang, J., Liu, S.M., Zhang, Y., Lin, H., Huang, Z.F., Wang, Y.Y., Zhang, X.D., Zhong, B., and Shu, H.B., 2014
Awards
- 2016 National Excellent Postdoctoral Innovation Talent Support Plan (First Session)
- 2017 Wuhan University Graduate Academic Innovation Award (Special Prize)
- 2017 National Natural Science Foundation of China
- 2019 National Excellent Young Scientists Fund (Talent Project)
- 2021 National Natural Science Foundation of China
- 2021 National Key Research and Development Program of the Ministry of Science and Technology (Youth Project)
- 2022 National Key Research and Development Program of the Ministry of Science and Technology (Youth Project)
