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Junjie Zhang
Immunology and Metabolion
Wuhan University
Hubei
Language: Chinese, English
Herpesvirus
Immunity
Therapy
Molecular Mechanisms
Antiviral
Host Factors
Lytic Reactivation
Viral Proteins
Oncolytic Viruses
Cancer Immunotherapy
Areas of Focus
- Herpesvirus infections, immunity, and therapy
- Molecular mechanisms of herpesvirus antagonism against host antiviral immune responses
- Identification of key viral proteins and host factors regulating herpesvirus lytic reactivation
- Development of oncolytic herpesviruses for cancer immunotherapy
Work Experience
- 2011-2018 - University of Southern California, Department of Molecular Microbiology and Immunology - Postdoctoral Researcher
- 2018-present - Wuhan University, Medical Research Institute, State Key Laboratory of Virology - Professor
Academic Background & Achievements
- 2001-2005 Bachelor: Peking University, School of Life Sciences
- 2005-2011 PhD: Chinese Academy of Sciences, Institute of Microbiology
- 2011 Zhu Li Yuehua Excellent Doctoral Graduate Award from the Chinese Academy of Sciences
Publications
- Non-canonical regulation of the reactivation of an oncogenic herpesvirus by the OTUD4-USP7 deubiquitinases, Wang S, Tian X, Zhou Y, Xie J, Gao M, Zhong Y, Zhang C, Yu K, Bai L, Qin Q, Zhong B, Lin D, Feng P, Lan K, Zhang J, 2024
- STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2, Zhang L, Jiang C, Zhong Y, Sun K, Jing H, Song J, Xie J, Zhou Y, Tian M, Zhang C, Sun X, Wang S, Cheng X, Zhang Y, Wei W, Li X, Fu B, Feng P, Wu B, Shu HB, Zhang J, 2023
- Genome-Wide CRISPR-Cas9 Screen Identifies SMCHD1 as a Restriction Factor for Herpesviruses, Tian X, Zhou Y, Wang S, Gao M, Xia Y, Li Y, Zhong Y, Xu W, Bai L, Fu B, Zhou Y, Lee HR, Deng H, Lan K, Feng P, Zhang J, 2023
- Oncolytic herpes simplex virus armed with a bacterial GBP1 degrader improves antitumor activity, Xie J, Wang S, Zhong Y, Gao M, Tian X, Zhang L, Pan D, Qin Q, Wu B, Lan K, Sun ZJ, Zhang J, 2023
- A Dual-Responsive STAT3 Inhibitor Nanoprodrug Combined with Oncolytic Virus Elicits Synergistic Antitumor Immune Responses by Igniting Pyroptosis, Su W, Qiu W, Li SJ, Wang S, Xie J, Yang QC, Xu J, Zhang J, Xu Z, Sun ZJ, 2022
- DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity, Sun X, Liu T, Zhao J, Xia, H, Xie J, Guo Y, Zhong L, Li M, Yang Q, Peng C, Rouvet I, Belot A, Shu HB, Feng P, Zhang J, 2020
- Species-specific deamidation of cGAS by herpes simplex virus UL37 protein facilitates viral replication, Zhang J, Zhao J, Xu S, Li J, He S, Zeng Y, Xie L, Xie N, Liu T, Lee K, Seo GJ, Chen L, Stabell AC, Xia Z, Sawyer SL, Jung JU, Huang C, Feng P, 2018
- IkappaB Kinase epsilon Is an NFATc1 Kinase that Inhibits T Cell Immune Response, Zhang J, Feng H, Zhao J, Feldman ER, Chen S, Yuan W, Huang C, Akbari O, Tibbetts SA, and Feng P, 2016
- Hijacking GPCRs by viral pathogens and tumor, Zhang J, Feng H, Xu S, Feng P, 2016
- Roles of IκB kinase ε in the innate immune defense and beyond, Zhang J, Tian M, Xia Z, Feng P, 2016
- Recombinant Murine Gamma Herpesvirus 68 Carrying KSHV G Protein-Coupled Receptor Induces Angiogenic Lesions in Mice, Zhang J, Zhu L, Lu X, Feldman ER, Keyes LR, Wang Y, Fan H, Feng H, Xia Z, Sun J, Jiang T, Gao S, Tibbetts SA, and Feng P, 2015
- Herpesviral G protein-coupled receptors activate NFAT to induce tumor formation via inhibiting the SERCA calcium ATPase, Zhang J, He S, Wang Y, Brulois K, Lan K, Jung JU, and Feng P, 2015
- An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction, Minassian A, Zhang J, He S, Zhao J, Zandi E, Saito T, Liang C, and Feng P, 2015
- Identification of novel virus inhibitors by influenza A virus specific reporter cell-based screening, Zhang J, Liu T, Tong X, Li G, Yan J, Ye X, 2011
- Cyclin T1/CDK9 interacts with influenza A virus polymerase and facilitates its association with cellular RNA polymerase II, Zhang J, Li G, Ye X, 2010
- Influenza A virus M1 blocks the classical complement pathway through interacting with C1qA, Zhang J, Li G, Liu X, Wang Z, Liu W, Ye X, 2009
Awards
- 2011: Zhu Li Yuehua Excellent Doctoral Graduate Award
- 2016: 19th International Workshop on KSHV and Related Agents Travel Award
