Professor | Chen Mo | Asia Growth Partners

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Name	Chen Mo
Contact Information	chenm7@sustech.edu.cn
Language ability	Chinese, English
Province	Guangdong

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Name

Chen Mo

Contact Information

chenm7@sustech.edu.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Southern University of Science and Technology
Faculty	Medical School
Academic Background & Achievements	2009-08 to 2013-12, PhD in Biology, National University of Singapore 2005-09 to 2009-06, Bachelor in Biotechnology, Sichuan University
Work Experience	2023-04 to present - Southern University of Science and Technology, School of Medicine, Department of Pharmacology, Associate Professor 2022-07 to 2023-03 - University of Wisconsin Madison, School of Medicine, Senior Scientist 2019-09 to 2022-07 - University of Wisconsin Madison, School of Medicine, Associate Scientist 2017-07 to 2019-09 - University of Wisconsin Madison, School of Medicine, Postdoctoral Researcher 2014-01 to 2017-06 - National University of Singapore, Department of Biology, Postdoctoral Researcher
Awards	2015: Singapore Cardiovascular Society Young Scholar Award 2009-2013: National University of Singapore Full Scholarship 2009: Sichuan Province Outstanding University Graduate 2007: National Scholarship

University/Lab Affiliation and Title

Southern University of Science and Technology

Faculty

Medical School

Academic Background & Achievements

2009-08 to 2013-12, PhD in Biology, National University of Singapore
2005-09 to 2009-06, Bachelor in Biotechnology, Sichuan University

Work Experience

2023-04 to present - Southern University of Science and Technology, School of Medicine, Department of Pharmacology, Associate Professor
2022-07 to 2023-03 - University of Wisconsin Madison, School of Medicine, Senior Scientist
2019-09 to 2022-07 - University of Wisconsin Madison, School of Medicine, Associate Scientist
2017-07 to 2019-09 - University of Wisconsin Madison, School of Medicine, Postdoctoral Researcher
2014-01 to 2017-06 - National University of Singapore, Department of Biology, Postdoctoral Researcher

Awards

2015: Singapore Cardiovascular Society Young Scholar Award
2009-2013: National University of Singapore Full Scholarship
2009: Sichuan Province Outstanding University Graduate
2007: National Scholarship

Areas of Focus	Molecular mechanisms of lipid metabolic signaling pathways in organelles Transport of lipids between organelles Complexes of lipids and effector proteins and their biological functions Localization and mechanisms of lipids in non-membrane structures within organelles Analysis of lipid metabolic functions in diseases and development of new drugs targeting these
Publications	A p53-phosphoinositide signalosome regulates nuclear AKT activation, Chen, M., Choi, S., Wen, T., Chen, C., Thapa, N., Lee, J. H., Cryns, V. L. & Anderson, R. A., 2022 Phosphatidylinositol-3 kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4, Thapa, N.#, Chen, M.# (#共同一作), Horn, H. T., Choi, S., Wen, T. & Anderson, R. A., 2020 A nuclear phosphoinositide kinase complex regulates p53, Choi, S.#, Chen, M.# (#共同一作), Cryns, V. L. & Anderson, R. A., 2019 Extracellular anti-angiogenic proteins augment an endosomal protein trafficking pathway to reach mitochondria and execute apoptosis in HUVECs, Chen, M., Qiu, T., Wu, J., Yang, Y., Wright, G. D., Wu, M. & Ge, R., 2018 Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction, Chen, M., Zhang, Y., Yu, V. C., Chong, Y. S., Yoshioka, T. & Ge, R., 2014 Assessing In Situ Phosphoinositide-Protein Interactions Through Fluorescence Proximity Ligation Assay in Cultured Cells, Chen, M., Horn, H. T., Wen, T., Cryns, V. L. & Anderson, R. A., 2021 The nuclear phosphoinositide response to stress, Chen, M., Wen, T., Horn, H. T., Chandrahas, V. K., Thapa, N., Choi, S., Cryns, V. L. & Anderson, R. A., 2020 The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif, Chen, M. #, Choi, S. .# (#共同一作), Jung, O. et al., 2019 Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-/-) mice, Kumar, S. #, Chen, M.# (#共同一作), Li, Y., Wong, F. H., Thiam, C. W., Hossain, M. Z., Poh, K. K., Hirohata, S., Ogawa, H., Angeli, V. & Ge, R., 2016 Proapoptotic Cyclic Peptide BC71 Targets Cell-Surface GRP78 and Functions as an Anticancer Therapeutic in Mice, Kao, C., Chandna, R., Ghode, A., Dsouza, C., Chen, M., Larsson, A., Lim, S. H., Wang, M., Cao, Z., Zhu, Y., Anand, G. S. & Ge, R., 2018 Angio-3, a 10-residue peptide derived from human plasminogen kringle 3, suppresses tumor growth in mice via impeding both angiogenesis and vascular permeability, Venugopal, S., Kao, C., Chandna, R., Sulochana, K. N., Subramanian, V., Chen, M., Kini, R. M. & Ge, R., 2018 Isthmin is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation, Venugopal, S., Chen, M., Liao, W., Er, S. Y., Wong, W. S. & Ge, R., 2015 Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin depending on its physical state, Zhang, Y., Chen, M., Venugopal, S., Zhou, Y., Xiang, W., Li, Y. H., Lin, Q., Kini, R. M., Chong, Y. S. & Ge, R., 2011

Areas of Focus

Molecular mechanisms of lipid metabolic signaling pathways in organelles
Transport of lipids between organelles
Complexes of lipids and effector proteins and their biological functions
Localization and mechanisms of lipids in non-membrane structures within organelles
Analysis of lipid metabolic functions in diseases and development of new drugs targeting these

Publications

A p53-phosphoinositide signalosome regulates nuclear AKT activation, Chen, M., Choi, S., Wen, T., Chen, C., Thapa, N., Lee, J. H., Cryns, V. L. & Anderson, R. A., 2022
Phosphatidylinositol-3 kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4, Thapa, N.#, Chen, M.# (#共同一作), Horn, H. T., Choi, S., Wen, T. & Anderson, R. A., 2020
A nuclear phosphoinositide kinase complex regulates p53, Choi, S.#, Chen, M.# (#共同一作), Cryns, V. L. & Anderson, R. A., 2019
Extracellular anti-angiogenic proteins augment an endosomal protein trafficking pathway to reach mitochondria and execute apoptosis in HUVECs, Chen, M., Qiu, T., Wu, J., Yang, Y., Wright, G. D., Wu, M. & Ge, R., 2018
Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction, Chen, M., Zhang, Y., Yu, V. C., Chong, Y. S., Yoshioka, T. & Ge, R., 2014
Assessing In Situ Phosphoinositide-Protein Interactions Through Fluorescence Proximity Ligation Assay in Cultured Cells, Chen, M., Horn, H. T., Wen, T., Cryns, V. L. & Anderson, R. A., 2021
The nuclear phosphoinositide response to stress, Chen, M., Wen, T., Horn, H. T., Chandrahas, V. K., Thapa, N., Choi, S., Cryns, V. L. & Anderson, R. A., 2020
The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif, Chen, M. #, Choi, S. .# (#共同一作), Jung, O. et al., 2019
Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-/-) mice, Kumar, S. #, Chen, M.# (#共同一作), Li, Y., Wong, F. H., Thiam, C. W., Hossain, M. Z., Poh, K. K., Hirohata, S., Ogawa, H., Angeli, V. & Ge, R., 2016
Proapoptotic Cyclic Peptide BC71 Targets Cell-Surface GRP78 and Functions as an Anticancer Therapeutic in Mice, Kao, C., Chandna, R., Ghode, A., Dsouza, C., Chen, M., Larsson, A., Lim, S. H., Wang, M., Cao, Z., Zhu, Y., Anand, G. S. & Ge, R., 2018
Angio-3, a 10-residue peptide derived from human plasminogen kringle 3, suppresses tumor growth in mice via impeding both angiogenesis and vascular permeability, Venugopal, S., Kao, C., Chandna, R., Sulochana, K. N., Subramanian, V., Chen, M., Kini, R. M. & Ge, R., 2018
Isthmin is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation, Venugopal, S., Chen, M., Liao, W., Er, S. Y., Wong, W. S. & Ge, R., 2015
Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin depending on its physical state, Zhang, Y., Chen, M., Venugopal, S., Zhou, Y., Xiang, W., Li, Y. H., Lin, Q., Kini, R. M., Chong, Y. S. & Ge, R., 2011

Lipid Metabolism Signaling Pathways Organelles Transport Effector Proteins Biological Functions Localization Non-Membrane Structures Disease Analysis Drug Development

Chengpeng Fan - Wuhan University

Jing Chen - University of Chinese Academy of Sciences

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