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陈默
Medical School
南方科技大学
广东省
Language: 中文, 英语
脂代谢
信号通路
细胞器
运输
效应蛋白
生物学功能
定位
非膜结构
疾病分析
药物开发
Areas of Focus
- 细胞器中脂代谢信号通路的分子机制
- 细胞器之间的脂质运输
- 脂质与效应蛋白的复合及其生物学功能
- 细胞器中非膜结构上的脂质定位及其作用机理
- 疾病中的脂代谢功能异常分析及针对这些的新药开发
Work Experience
- 2023-04至今 南方科技大学医学院药理学系，副教授
- 2022-07至 2023-03 美国威斯康星大学麦迪逊分校医学院, 高级科学家
- 2019-09至 2022-07 美国威斯康星大学麦迪逊分校医学院, 副科学家
- 2017-07至 2019-09 美国威斯康星大学麦迪逊分校医学院, 博士后
- 2014-01至 2017-06 新加坡国立大学生物系，博士后
Academic Background & Achievements
- 2009-08 至 2013-12, 新加坡国立大学, 生物学, 博士
- 2005-09 至 2009-06, 四川大学, 生物技术, 学士
Publications
- A p53-phosphoinositide signalosome regulates nuclear AKT activation, Chen, M., Choi, S., Wen, T., Chen, C., Thapa, N., Lee, J. H., Cryns, V. L. & Anderson, R. A., 2022
- Phosphatidylinositol-3 kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4, Thapa, N.#, Chen, M.# (#共同一作), Horn, H. T., Choi, S., Wen, T. & Anderson, R. A., 2020
- A nuclear phosphoinositide kinase complex regulates p53, Choi, S.#, Chen, M.# (#共同一作), Cryns, V. L. & Anderson, R. A., 2019
- Extracellular anti-angiogenic proteins augment an endosomal protein trafficking pathway to reach mitochondria and execute apoptosis in HUVECs, Chen, M., Qiu, T., Wu, J., Yang, Y., Wright, G. D., Wu, M. & Ge, R., 2018
- Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction, Chen, M., Zhang, Y., Yu, V. C., Chong, Y. S., Yoshioka, T. & Ge, R., 2014
- Assessing In Situ Phosphoinositide-Protein Interactions Through Fluorescence Proximity Ligation Assay in Cultured Cells, Chen, M., Horn, H. T., Wen, T., Cryns, V. L. & Anderson, R. A., 2021
- The nuclear phosphoinositide response to stress, Chen, M., Wen, T., Horn, H. T., Chandrahas, V. K., Thapa, N., Choi, S., Cryns, V. L. & Anderson, R. A., 2020
- The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif, Chen, M. #, Choi, S. .# (#共同一作), Jung, O. et al., 2019
- Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-/-) mice, Kumar, S. #, Chen, M.# (#共同一作), Li, Y., Wong, F. H., Thiam, C. W., Hossain, M. Z., Poh, K. K., Hirohata, S., Ogawa, H., Angeli, V. & Ge, R., 2016
- Proapoptotic Cyclic Peptide BC71 Targets Cell-Surface GRP78 and Functions as an Anticancer Therapeutic in Mice, Kao, C., Chandna, R., Ghode, A., Dsouza, C., Chen, M., Larsson, A., Lim, S. H., Wang, M., Cao, Z., Zhu, Y., Anand, G. S. & Ge, R., 2018
- Angio-3, a 10-residue peptide derived from human plasminogen kringle 3, suppresses tumor growth in mice via impeding both angiogenesis and vascular permeability, Venugopal, S., Kao, C., Chandna, R., Sulochana, K. N., Subramanian, V., Chen, M., Kini, R. M. & Ge, R., 2018
- Isthmin is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation, Venugopal, S., Chen, M., Liao, W., Er, S. Y., Wong, W. S. & Ge, R., 2015
- Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin
Awards
- 2015: 新加坡心血管协会优秀青年学者奖励
- 2009-2013: 新加坡国立大学全额奖学金
- 2009: 四川省优秀大学毕业生
- 2007: 国家奖学金
