Professor | 陈默 | 数字化转型顾问

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Name	陈默
Contact Information	chenm7@sustech.edu.cn
Language ability	中文, 英语
Province	广东省

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Name

陈默

Contact Information

chenm7@sustech.edu.cn

Language ability

中文, 英语

Province

广东省

University/Lab Affiliation and Title	南方科技大学
Faculty	Medical School
Academic Background & Achievements	2009-08 至 2013-12, 新加坡国立大学, 生物学, 博士 2005-09 至 2009-06, 四川大学, 生物技术, 学士
Work Experience	2023-04至今南方科技大学医学院药理学系，副教授 2022-07至 2023-03 美国威斯康星大学麦迪逊分校医学院, 高级科学家 2019-09至 2022-07 美国威斯康星大学麦迪逊分校医学院, 副科学家 2017-07至 2019-09 美国威斯康星大学麦迪逊分校医学院, 博士后 2014-01至 2017-06 新加坡国立大学生物系，博士后
Awards	2015: 新加坡心血管协会优秀青年学者奖励 2009-2013: 新加坡国立大学全额奖学金 2009: 四川省优秀大学毕业生 2007: 国家奖学金

University/Lab Affiliation and Title

南方科技大学

Faculty

Medical School

Academic Background & Achievements

2009-08 至 2013-12, 新加坡国立大学, 生物学, 博士
2005-09 至 2009-06, 四川大学, 生物技术, 学士

Work Experience

2023-04至今南方科技大学医学院药理学系，副教授
2022-07至 2023-03 美国威斯康星大学麦迪逊分校医学院, 高级科学家
2019-09至 2022-07 美国威斯康星大学麦迪逊分校医学院, 副科学家
2017-07至 2019-09 美国威斯康星大学麦迪逊分校医学院, 博士后
2014-01至 2017-06 新加坡国立大学生物系，博士后

Awards

2015: 新加坡心血管协会优秀青年学者奖励
2009-2013: 新加坡国立大学全额奖学金
2009: 四川省优秀大学毕业生
2007: 国家奖学金

Areas of Focus	细胞器中脂代谢信号通路的分子机制细胞器之间的脂质运输脂质与效应蛋白的复合及其生物学功能细胞器中非膜结构上的脂质定位及其作用机理疾病中的脂代谢功能异常分析及针对这些的新药开发
Publications	A p53-phosphoinositide signalosome regulates nuclear AKT activation, Chen, M., Choi, S., Wen, T., Chen, C., Thapa, N., Lee, J. H., Cryns, V. L. & Anderson, R. A., 2022 Phosphatidylinositol-3 kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4, Thapa, N.#, Chen, M.# (#共同一作), Horn, H. T., Choi, S., Wen, T. & Anderson, R. A., 2020 A nuclear phosphoinositide kinase complex regulates p53, Choi, S.#, Chen, M.# (#共同一作), Cryns, V. L. & Anderson, R. A., 2019 Extracellular anti-angiogenic proteins augment an endosomal protein trafficking pathway to reach mitochondria and execute apoptosis in HUVECs, Chen, M., Qiu, T., Wu, J., Yang, Y., Wright, G. D., Wu, M. & Ge, R., 2018 Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction, Chen, M., Zhang, Y., Yu, V. C., Chong, Y. S., Yoshioka, T. & Ge, R., 2014 Assessing In Situ Phosphoinositide-Protein Interactions Through Fluorescence Proximity Ligation Assay in Cultured Cells, Chen, M., Horn, H. T., Wen, T., Cryns, V. L. & Anderson, R. A., 2021 The nuclear phosphoinositide response to stress, Chen, M., Wen, T., Horn, H. T., Chandrahas, V. K., Thapa, N., Choi, S., Cryns, V. L. & Anderson, R. A., 2020 The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif, Chen, M. #, Choi, S. .# (#共同一作), Jung, O. et al., 2019 Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-/-) mice, Kumar, S. #, Chen, M.# (#共同一作), Li, Y., Wong, F. H., Thiam, C. W., Hossain, M. Z., Poh, K. K., Hirohata, S., Ogawa, H., Angeli, V. & Ge, R., 2016 Proapoptotic Cyclic Peptide BC71 Targets Cell-Surface GRP78 and Functions as an Anticancer Therapeutic in Mice, Kao, C., Chandna, R., Ghode, A., Dsouza, C., Chen, M., Larsson, A., Lim, S. H., Wang, M., Cao, Z., Zhu, Y., Anand, G. S. & Ge, R., 2018 Angio-3, a 10-residue peptide derived from human plasminogen kringle 3, suppresses tumor growth in mice via impeding both angiogenesis and vascular permeability, Venugopal, S., Kao, C., Chandna, R., Sulochana, K. N., Subramanian, V., Chen, M., Kini, R. M. & Ge, R., 2018 Isthmin is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation, Venugopal, S., Chen, M., Liao, W., Er, S. Y., Wong, W. S. & Ge, R., 2015 Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin

Areas of Focus

细胞器中脂代谢信号通路的分子机制
细胞器之间的脂质运输
脂质与效应蛋白的复合及其生物学功能
细胞器中非膜结构上的脂质定位及其作用机理
疾病中的脂代谢功能异常分析及针对这些的新药开发

Publications

A p53-phosphoinositide signalosome regulates nuclear AKT activation, Chen, M., Choi, S., Wen, T., Chen, C., Thapa, N., Lee, J. H., Cryns, V. L. & Anderson, R. A., 2022
Phosphatidylinositol-3 kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4, Thapa, N.#, Chen, M.# (#共同一作), Horn, H. T., Choi, S., Wen, T. & Anderson, R. A., 2020
A nuclear phosphoinositide kinase complex regulates p53, Choi, S.#, Chen, M.# (#共同一作), Cryns, V. L. & Anderson, R. A., 2019
Extracellular anti-angiogenic proteins augment an endosomal protein trafficking pathway to reach mitochondria and execute apoptosis in HUVECs, Chen, M., Qiu, T., Wu, J., Yang, Y., Wright, G. D., Wu, M. & Ge, R., 2018
Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction, Chen, M., Zhang, Y., Yu, V. C., Chong, Y. S., Yoshioka, T. & Ge, R., 2014
Assessing In Situ Phosphoinositide-Protein Interactions Through Fluorescence Proximity Ligation Assay in Cultured Cells, Chen, M., Horn, H. T., Wen, T., Cryns, V. L. & Anderson, R. A., 2021
The nuclear phosphoinositide response to stress, Chen, M., Wen, T., Horn, H. T., Chandrahas, V. K., Thapa, N., Choi, S., Cryns, V. L. & Anderson, R. A., 2020
The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif, Chen, M. #, Choi, S. .# (#共同一作), Jung, O. et al., 2019
Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-/-) mice, Kumar, S. #, Chen, M.# (#共同一作), Li, Y., Wong, F. H., Thiam, C. W., Hossain, M. Z., Poh, K. K., Hirohata, S., Ogawa, H., Angeli, V. & Ge, R., 2016
Proapoptotic Cyclic Peptide BC71 Targets Cell-Surface GRP78 and Functions as an Anticancer Therapeutic in Mice, Kao, C., Chandna, R., Ghode, A., Dsouza, C., Chen, M., Larsson, A., Lim, S. H., Wang, M., Cao, Z., Zhu, Y., Anand, G. S. & Ge, R., 2018
Angio-3, a 10-residue peptide derived from human plasminogen kringle 3, suppresses tumor growth in mice via impeding both angiogenesis and vascular permeability, Venugopal, S., Kao, C., Chandna, R., Sulochana, K. N., Subramanian, V., Chen, M., Kini, R. M. & Ge, R., 2018
Isthmin is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation, Venugopal, S., Chen, M., Liao, W., Er, S. Y., Wong, W. S. & Ge, R., 2015
Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin

脂代谢信号通路细胞器运输效应蛋白生物学功能定位非膜结构疾病分析药物开发

范成鹏 - 武汉大学

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