Yuhui Hu

huyh@sustech.edu.cn

English, Chinese, German

Guangdong

Southern University of Science and Technology

Medical School

• 2002-2006 PhD in Functional Genomics, Max Planck Institute for Molecular Genetics, Germany
• 1998-2001 Master in Pharmacognosy, West China School of Pharmacy (later Sichuan University), China
• 1990-1994 Bachelor in Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, China
• Established independent laboratory in 2007 at Max Planck Institute for Molecular Genetics
• Published over 40 research papers with nearly 2000 citations

• 2022.03-present Associate Professor, Researcher at School of Medicine, Department of Pharmacology, Southern University of Science and Technology
• 2016.08-2022.03 Independent PI, Associate Research Professor, Doctoral Supervisor at Department of Biology, Southern University of Science and Technology
• 2009-2016 Senior Researcher at Max Delbrück Center for Molecular Medicine / Berlin Institute for Medical Systems Biology, Germany
• 2007-2009 Group Leader (Chemistry and Drug Genomics) at Max Planck Institute for Molecular Genetics, Germany
• 2006-2007 Postdoctoral Researcher at Max Planck Institute for Molecular Genetics, Germany
• 2002.1-2002.10 Visiting Scholar at Hong Kong Baptist University
• 1994-2002 Assistant, Lecturer at West China School of Pharmacy (merged into Sichuan University in 2001)

• 2021 Shenzhen Industrial Development and Innovation Talent Award
• 2020 Southern University of Science and Technology Outstanding Patent Award

Functional genomics, especially combining high-throughput sequencing, single-cell spatiotemporal omics, CRISPR gene editing technology for drug function and molecular mechanism research.
Precision medicine-based cancer genomics and chemical genomics, focusing on cancer drug resistance reversal, early detection, and targeted classification treatment.
Cell biology research combining omics and chemical biology, focusing on compound-induced cell apoptosis, mitochondrial dysfunction, DNA damage and repair, and epigenetic changes.
Preclinical new drug development based on new mechanisms of action, including natural products.

• High-resolution 3D spatiotemporal transcriptomic maps of developing Drosophila embryos and larvae, Mingyue Wang, Qinan Hu, Tianhang Lv, Yuhang Wang, Qing Lan, Zhencheng Tu, Rong Xiang, Yanrong Wei, Kai Han, Yanru An, Mengnan Cheng, Jiangshan Xu, Miguel A.Esteban, Haorong Lu, Wangsheng Li, Shaofang Zhang, Ao Chen, Wei Chen, Yuxiang Li, Xiaoshan Wang, Xun Xu, Yuhui Hu, Longqi Liu, 2022
• Diterpenoid Vinigrol specifically activates ATF4/DDIT3-mediated PERK arm of unfolded protein response to drive non-apoptotic death of breast cancer cells, Wencheng Wei, Yunfei Li, Chuanxi Wang, Sanxing Gao, Hao Wang, Yan Zhao, Ziying Gao, Yanxiang Jiang, Li Zhao, Hao Gao, Xinsheng Yao, Yuhui Hu, 2022
• CRISPR-iPAS: a novel dCAS13-based method for alternative polyadenylation interference, Shuye Tian, Bin Zhang, Yuhao He, Zhiyuan Sun, Jun Li, Yisheng Li, Hongyang Yi, Yan Zhao, Xudong Zou, Yunfei Li, Huanhuan Cui, Liang Fang, Xin Gao, Yuhui Hu, Wei Chen, 2022
• Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents, Weizheng Liang, Guipeng Li, Huanhuan Cui, Yukai Wang, Wencheng Wei, Siyue Sun, Diwen Gan, Rui Chen, Hongyang Yi, Bernhard Schaefke, Yuhui Hu, Qi Zhou, Wei Li, Wei Chen, 2021
• Mammalian splicing divergence is shaped by drift, buffering in trans, and a scaling law, Xudong Zou, Bernhard Schaefke, Yisheng Li, Fujian Jia, Wei Sun, Guipeng Li, Weizheng Liang, Tristan Reif, Florian Heyd, Qingsong Gao, Shuye Tian, Yanping Li, Yisen Tang, Liang Fang, Yuhui Hu, Wei Chen, 2021
• The strand-biased transcription of SARS-CoV-2 and unbalanced inhibition by remdesivir, Yan Zhao, Jing Sun, Yunfei Li, Zhengxuan Li, Yu Xie, Ruoqing Feng, Jincun Zhao, Yuhui Hu, 2021
• CASB: a concanavalin A‐based sample barcoding strategy for single cell Sequencing, Liang Fang, Guipeng Li, Zhiyuan Sun, Qionghua Zhu, Huanhuan Cui, Yunfei Li, Jingwen Zhang, Weizheng Liang, Wencheng Wei, Yuhui Hu, Wei Chen, 2021
• DeeReCT-APA: Prediction of Alternative Polyadenylation Site Usage Through Deep Learning, Zhongxiao Li, Yisheng Li, Bin Zhang, Yu Li, Yongkang Long, Juexiao Zhou, Xudong Zou, Min Zhang, Yuhui Hu, Wei Chen, Xin Gao, 2021
• CIGAR‐seq, a CRISPR/Cas‐based method for unbiased screening of novel mRNA modification regulators, Hongyang Yi, Guipeng Li, Yongkang Long, Weizheng Liang, Huanhuan Cui, Bin Zhang, Ying Tan, Yunfei Li, Luochen Shen, Daqi Deng, Yisen Tang, Chenyu Mao, Shuye Tian, Yunting Cai, Qionghua Zhu, Yuhui Hu, Wei Chen, Liang Fang, 2020
• Integrative multi-omics analysis of a colon cancer cell line with heterogeneous Wnt activity revealed RUNX2 as an epigenetic regulator of EMT, Hongyang Yi, Guipeng Li, Yongkang Long, Weizheng Liang, Huanhuan Cui, Bin Zhang, Ying Tan, Yunfei Li, Luochen Shen, Daqi Deng, Yisen Tang, Chenyu Mao, Shuye Tian, Yunting Cai, Qionghua Zhu, Yuhui Hu, Wei Chen, Liang Fang, 2020
• Pan-tissue analysis of allelic alternative polyadenylation suggests widespread functional regulation, Yisheng Li, Bernhard Schaefke, Xudong Zou, Min Zhang, Florian Heyd, Wei Sun, Bin Zhang, Guipeng Li, Weizheng Liang, Yuhao He, Juexiao Zhou, Yunfei Li, Liang Fang, Yuhui Hu, Wei Chen, 2020
• Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus, Xi Wang, Xintian You, Julian Langer, Jingyi Hou, Fiona Rupprecht, Irena Vlatkovic, Claudia Quedenau, Georgi Tushev, Irina Epstein, Bernhard Schaefke, Wei Sun, Liang Fang, Guipeng Li, Yuhui Hu, Erin Schuman, Wei Chen, 2019
• A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing, Tao Chen, Bin Zhang, Thomas Ziegenhals, Archana B. Prusty, Sebastian Frohler, Clemens Grimm, Yuhui Hu, Bernhard Schaefke, Liang Fang, Min Zhang, Nadine Kraemer, Angela M. Kaindl, Utz Fischer, Wei Chen, 2019
• IVS2vec: A tool of Inverse Virtual Screening based on word2vec and deep learning techniques, Haiping Zhang, Linbu Liao, Yunting Cai, Yuhui Hu