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Yunjiao He
Medical School
Southern University of Science and Technology
Guangdong
Language: Chinese, English
Protein Structure
Enzymes
Carbohydrates
Molecular Interaction
X-Ray Crystallography
Nmr Spectroscopy
Bioinformatics
Molecular Dynamics
Drug Design
Biomolecular Engineering
Areas of Focus
- Structural Biology
- Glycochemistry
Work Experience
- 2006.07-2008.08 - WuXi AppTec, Drug Synthesis Researcher
- 2013.10-2014.07 - Hong Kong Polytechnic University, Research Assistant
- 2014.07-2016.07 - Hong Kong Polytechnic University, Postdoctoral Researcher
- 2016.09-2019.05 - Southern University of Science and Technology, Postdoctoral Researcher
Academic Background & Achievements
- 1999.9-2003.6 Bachelor: Wuhan University, Pharmacy
- 2003.9-2006.6 Master: Wuhan University, Pharmaceutical Chemistry
- 2009.1-2013.10 PhD: Hong Kong Polytechnic University, Biochemistry and Molecular Biology
Publications
- Targeting the potent Beclin 1-UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking, Shuai Wu, Yunjiao He, et al., 2018
- Modified Penicillin Molecule with Carbapenem-Like Stereochemistry Specifically Inhibits Class C beta-Lactamases, Xuehua Pan, Yunjiao He, et al., 2017
- Crystallographic Snapshots of Class A beta-Lactamase Catalysis Reveal Structural Changes That Facilitate beta-Lactam Hydrolysis, Xuehua Pan, Yunjiao He, et al., 2017
- Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation, Xuehua Pan, Yunjiao He, et al., 2014
- A general and facile synthetic approach to N-alpha-Boc ureidoalanine derivatives, Teng H., Yunjiao He, et al., 2006
- Novel intermediates in the active site of Class A β-lactamase reveal critical factors that coordinate the catalytic water molecule for nucleophilic attack on β-lactam acyl adduct, Yunjiao He, Lei J., Pan X., Huang X., Zhao Y., 2019
