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Yunjiao He
Medical School
Southern University of Science and Technology
Guangdong
Language: Chinese, English
Protein Structure
Enzyme Mechanisms
Molecular Interaction
Biological Systems
X-Ray Crystallography
Nmr Spectroscopy
Computational Modeling
Bioinformatics
Molecular Dynamics
Drug Design
Areas of Focus
- Structural Biology
- Glycochemistry
Work Experience
- 2006.07-2008.08 - Shanghai PharmaTech Co., Ltd - Drug Synthesis Researcher
- 2013.10-2014.07 - Hong Kong Polytechnic University, Research Assistant
- 2014.07-2016.07 - Hong Kong Polytechnic University, Postdoctoral Fellow
- 2016.09-2019.05 - Southern University of Science and Technology, Postdoctoral Fellow
Academic Background & Achievements
- 1999-2003 Bachelor in Pharmacy: Wuhan University
- 2003-2006 Master in Pharmaceutical Chemistry: Wuhan University
- 2009-2013 PhD in Biochemistry and Molecular Biology: Hong Kong Polytechnic University
Publications
- Targeting the potent Beclin 1-UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking, Shuai Wu, Yunjiao He, et al., 2018
- Modified Penicillin Molecule with Carbapenem-Like Stereochemistry Specifically Inhibits Class C beta-Lactamases, Xuehua Pan, Yunjiao He, et al., 2017
- Crystallographic Snapshots of Class A beta-Lactamase Catalysis Reveal Structural Changes That Facilitate beta-Lactam Hydrolysis, Xuehua Pan, Yunjiao He, et al., 2017
- Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation, Xuehua Pan, Yunjiao He, et al., 2014
- A general and facile synthetic approach to N-alpha-Boc ureidoalanine derivatives, Teng H., Yunjiao He, et al., 2006
- Novel intermediates in the active site of Class A β-lactamase reveal critical factors that coordinate the catalytic water molecule for nucleophilic attack on β-lactam acyl adduct, Yun jiao He, et al., 2019
