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Yao Wang Li
Life Science
Southern University of Science and Technology
Guangdong
Language: Chinese, English
Cryo-Em
Electron Diffraction
Single-Particle Analysis
Electron Tomography
Biomolecular Structures
Nanocrystals
Helical Reconstruction
Parkinson'S Disease
Alpha-Synuclein
High-Resolution
Areas of Focus
- Cryo-electron microscopy methodology
- Structural analysis of biomolecules
- Neurodegenerative diseases and drug research
Work Experience
- 2021-Present, Southern University of Science and Technology, Research Assistant Professor
- 2017-2021, Tsinghua University, Postdoctoral Researcher
- 2015-2017, Leiden University, Postdoctoral Researcher, Visiting
Academic Background & Achievements
- 2011-2017 PhD: Leiden University
- 2008-2011 Master's: China Agricultural University
- 2004-2008 Bachelor's: Jiangxi Agricultural University
- First researcher in China to resolve high-resolution fibril structures
Publications
- Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a novel fibril structure, Zhao K.*, Li Y.W.*, Liu Z., Long H. Zhao C., Luo F., Sun Y., Tao Y., Su X., Li D., Li X., Liu C., 2020
- Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy, Li Y.W.*, Zhao C.*, Luo F.*, Liu Z., Gui X., Luo Z., Zhang X., Li D., Liu C., Li X., 2018
- Torsional refrigeration by twisted, coiled, and supercoiled fibers, Wang R., Fang S., Xiao Y., Gao E., Jiang N., Li, Y.W., Mou L., Shen Y., Zhao W., Li S.,FonSeca A., Galvao D., Chen M., He W., Yu K., Lu H., Wang X., Qian D., Aliev A., Li N.,Haines C., Liu Z., Mu J., Wang Z., Yin S., Lima M., An B., Zhou X., Liu Z., Baughman R., 2019
- Lattice filter for processing image data of three-dimensional protein nanocrystals, van Genderen E.*, Li Y.W.*, Nederlof I., Abrahams,J.P., 2016
- Imaging protein three-dimensional nanocrystals with cryo-EM, Nederlof, I, Li Y.W., van Heel, M., Abrahams, J.P., 2013
- A Medipix quantum area detector allows rotation electron diffraction data collection from submicrometre three-dimensional protein crystals, Nederlof, I, van Genderen, E., Li Y.W., Abrahams, J.P., 2013
- Structure-activity relationship study of antioxidative peptides by QSAR modeling: the amino acid next to C-terminal affects the activity, Li Y.W., Li B., He J., Qian P., 2011
Awards
- 2018 Guo Kexin Symposium Travel Award
- 2018 National Natural Science Foundation of China Young Scientist Fund
- 2017 China Postdoctoral Science Foundation Grant
- 2017 Tsinghua University Center for Structural Biology Excellence Scholar
- 2017 Tsinghua University Postdoctoral Support Plan
- 2011 National Graduate Student Program for Building High-Level Universities
- 2011 China Agricultural University Top Ten Outstanding Master's Thesis
- 2009 China Agricultural University Research Achievement Award
