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Shi Zhaoying
Life Science
Southern University of Science and Technology
Guangdong
Language: Chinese, English
Zygotic Genome Activation
Maternal Factors
Embryonic Hybrid Lethality
Whole-Genome Regulatory Elements
Regenerative Capacity
Xenopus
Gene Editing
Crispr/Cas9
Genetic Engineering
Disease Modeling
Areas of Focus
- Identification of maternal factors regulating zygotic genome activation
- Mechanisms of embryonic hybrid lethality
- Functional identification of whole-genome regulatory elements
- Mechanisms regulating regenerative capacity in Xenopus
- Development and optimization of gene editing techniques
Work Experience
- 2023.11 - Present, Southern University of Science and Technology, School of Life Sciences, Research Assistant Professor
- 2023.01 - 2023.10, Southern University of Science and Technology, School of Life Sciences, Senior Research Scholar
- 2014.09 - 2018.08, Southern University of Science and Technology, Department of Biology, Assistant Researcher
- 2013.07 - 2014.08, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Research Intern
Academic Background & Achievements
- 2018-2022 PhD in Biomedical Engineering, Harbin Institute of Technology (Joint program with Southern University of Science and Technology), Supervisor: Associate Professor Chen Yonglong
- Master's degree in Basic Veterinary Medicine, Guizhou University, 2010-2013
- Bachelor's degree in Veterinary Medicine, Guizhou University, 2006-2010
Publications
- Activation of P53 pathway contributes to Xenopus hybrid inviability, Shi, Z., Liu, G., Jiang, H., Shi, S., Zhang, X., Deng, Y., Chen, Y., 2023
- Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis, Shi, Z., Xu, J., Niu, L., Shen, W., Yan, S., Tan, Y., Quan, X., Cheung, E., Huang, K., Chen, Y., Li, L., Hou, C., 2023
- Expanding the CRISPR/Cas genome-editing scope in Xenopus tropicalis, Shi, Z., Jiang, H., Liu, G., Shi, S., Zhang, X., Chen, Y., 2022
- Disruption of tp53 leads to cutaneous nevus and melanoma formation in Xenopus tropicalis, Ran, R., Li, L., Shi, Z., Liu, G., Jiang, H., Fang, L., Xu, T., Huang, J., Chen, W., Chen, Y., 2022
- Three-dimensional folding dynamics of the Xenopus tropicalis genome, Niu, L., Shen, W., Shi, Z., Tan, Y., He, N., Wan, J., Sun, J., Zhang, Y., Huang, Y., Wang, W., Fang, C., Li, J., Zheng, P., Cheung, E., Chen, Y., Li, L., Hou, C., 2021
- Modeling human point mutation diseases in Xenopus tropicalis with a modified CRISPR/Cas9 system, Shi, Z., Xin, H., Tian, D., Lian, J., Wang, J., Liu, G., Ran, R., Shi, S., Zhang, Z., Shi, Y., Deng, Y., Hou, C., Chen, Y., 2019
- Customized one-step preparation of sgRNA transcription templates via overlapping PCR Using short primers and its application in vitro and in vivo gene editing, Hu, Z., Wang, L., Shi, Z., Jiang, J., Li, X., Chen, Y., Li, K., Luo, D., 2019
- EphA7 regulates claudin6 and pronephros development in Xenopus, Sun, J., Wang, X., Shi, Y., Li, J., Li, C., Shi, Z., Chen, Y., Mao, B., 2018
- Ligase IV inhibitor SCR7 enhances gene editing directed by CRISPR-Cas9 and ssODN in human cancer cells, Hu, Z., Shi, Z., Guo, X., Jiang, B., Wang, G., Luo, D., Chen, Y., Zhu, Y. S., 2018
- Targeted integration of genes in Xenopus tropicalis, Shi, Z., Tian, D., Xin, H., Lian, J., Guo, X., Chen, Y., 2017
- Efficient genome editing of genes involved in neural crest development using the CRISPR/Cas9 system in Xenopus embryos, Liu, Z., Cheng, T. T., Shi, Z., Liu, Z., Lei, Y., Wang, C., Shi, W., Chen, X., Qi, X., Cai, D., Feng, B., Deng, Y., Chen, Y., Zhao, H., 2016
- Targeted gene disruption in Xenopus laevis using CRISPR/Cas9, Wang, F., Shi, Z., Cui, Y., Guo, X., Shi, Y. B., Chen, Y., 2015
- Heritable CRISPR/Cas9-mediated targeted integration in Xenopus tropicalis, Shi, Z., Wang, F., Cui, Y., Liu, Z., Guo, X., Zhang, Y., Deng, Y., Zhao, H., Chen, Y., 2015
- Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis, Guo, X., Zhang, T., Hu, Z., Zhang, Y., Shi, Z., Wang, Q., Cui, Y., Wang, F., Zhao, H., Chen, Y., 2014
