Professor | Shi Zhaoying | Asia Growth Partners

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Name	Shi Zhaoying
Contact Information	shizy3@mail.sustech.edu.cn
Language ability	Chinese, English
Province	Guangdong

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Name

Shi Zhaoying

Contact Information

shizy3@mail.sustech.edu.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Southern University of Science and Technology
Faculty	Life Sciences
Academic Background & Achievements	2018-2022 PhD in Biomedical Engineering, Harbin Institute of Technology (Joint program with Southern University of Science and Technology), Supervisor: Associate Professor Chen Yonglong Master's degree in Basic Veterinary Medicine, Guizhou University, 2010-2013 Bachelor's degree in Veterinary Medicine, Guizhou University, 2006-2010
Work Experience	2023.11 - Present, Southern University of Science and Technology, School of Life Sciences, Research Assistant Professor 2023.01 - 2023.10, Southern University of Science and Technology, School of Life Sciences, Senior Research Scholar 2014.09 - 2018.08, Southern University of Science and Technology, Department of Biology, Assistant Researcher 2013.07 - 2014.08, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Research Intern

University/Lab Affiliation and Title

Southern University of Science and Technology

Faculty

Life Sciences

Academic Background & Achievements

2018-2022 PhD in Biomedical Engineering, Harbin Institute of Technology (Joint program with Southern University of Science and Technology), Supervisor: Associate Professor Chen Yonglong
Master's degree in Basic Veterinary Medicine, Guizhou University, 2010-2013
Bachelor's degree in Veterinary Medicine, Guizhou University, 2006-2010

Work Experience

2023.11 - Present, Southern University of Science and Technology, School of Life Sciences, Research Assistant Professor
2023.01 - 2023.10, Southern University of Science and Technology, School of Life Sciences, Senior Research Scholar
2014.09 - 2018.08, Southern University of Science and Technology, Department of Biology, Assistant Researcher
2013.07 - 2014.08, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Research Intern

Areas of Focus	Identification of maternal factors regulating zygotic genome activation Mechanisms of embryonic hybrid lethality Functional identification of whole-genome regulatory elements Mechanisms regulating regenerative capacity in Xenopus Development and optimization of gene editing techniques
Publications	Activation of P53 pathway contributes to Xenopus hybrid inviability, Shi, Z., Liu, G., Jiang, H., Shi, S., Zhang, X., Deng, Y., Chen, Y., 2023 Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis, Shi, Z., Xu, J., Niu, L., Shen, W., Yan, S., Tan, Y., Quan, X., Cheung, E., Huang, K., Chen, Y., Li, L., Hou, C., 2023 Expanding the CRISPR/Cas genome-editing scope in Xenopus tropicalis, Shi, Z., Jiang, H., Liu, G., Shi, S., Zhang, X., Chen, Y., 2022 Disruption of tp53 leads to cutaneous nevus and melanoma formation in Xenopus tropicalis, Ran, R., Li, L., Shi, Z., Liu, G., Jiang, H., Fang, L., Xu, T., Huang, J., Chen, W., Chen, Y., 2022 Three-dimensional folding dynamics of the Xenopus tropicalis genome, Niu, L., Shen, W., Shi, Z., Tan, Y., He, N., Wan, J., Sun, J., Zhang, Y., Huang, Y., Wang, W., Fang, C., Li, J., Zheng, P., Cheung, E., Chen, Y., Li, L., Hou, C., 2021 Modeling human point mutation diseases in Xenopus tropicalis with a modified CRISPR/Cas9 system, Shi, Z., Xin, H., Tian, D., Lian, J., Wang, J., Liu, G., Ran, R., Shi, S., Zhang, Z., Shi, Y., Deng, Y., Hou, C., Chen, Y., 2019 Customized one-step preparation of sgRNA transcription templates via overlapping PCR Using short primers and its application in vitro and in vivo gene editing, Hu, Z., Wang, L., Shi, Z., Jiang, J., Li, X., Chen, Y., Li, K., Luo, D., 2019 EphA7 regulates claudin6 and pronephros development in Xenopus, Sun, J., Wang, X., Shi, Y., Li, J., Li, C., Shi, Z., Chen, Y., Mao, B., 2018 Ligase IV inhibitor SCR7 enhances gene editing directed by CRISPR-Cas9 and ssODN in human cancer cells, Hu, Z., Shi, Z., Guo, X., Jiang, B., Wang, G., Luo, D., Chen, Y., Zhu, Y. S., 2018 Targeted integration of genes in Xenopus tropicalis, Shi, Z., Tian, D., Xin, H., Lian, J., Guo, X., Chen, Y., 2017 Efficient genome editing of genes involved in neural crest development using the CRISPR/Cas9 system in Xenopus embryos, Liu, Z., Cheng, T. T., Shi, Z., Liu, Z., Lei, Y., Wang, C., Shi, W., Chen, X., Qi, X., Cai, D., Feng, B., Deng, Y., Chen, Y., Zhao, H., 2016 Targeted gene disruption in Xenopus laevis using CRISPR/Cas9, Wang, F., Shi, Z., Cui, Y., Guo, X., Shi, Y. B., Chen, Y., 2015 Heritable CRISPR/Cas9-mediated targeted integration in Xenopus tropicalis, Shi, Z., Wang, F., Cui, Y., Liu, Z., Guo, X., Zhang, Y., Deng, Y., Zhao, H., Chen, Y., 2015 Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis, Guo, X., Zhang, T., Hu, Z., Zhang, Y., Shi, Z., Wang, Q., Cui, Y., Wang, F., Zhao, H., Chen, Y., 2014

Areas of Focus

Identification of maternal factors regulating zygotic genome activation
Mechanisms of embryonic hybrid lethality
Functional identification of whole-genome regulatory elements
Mechanisms regulating regenerative capacity in Xenopus
Development and optimization of gene editing techniques

Publications

Activation of P53 pathway contributes to Xenopus hybrid inviability, Shi, Z., Liu, G., Jiang, H., Shi, S., Zhang, X., Deng, Y., Chen, Y., 2023
Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis, Shi, Z., Xu, J., Niu, L., Shen, W., Yan, S., Tan, Y., Quan, X., Cheung, E., Huang, K., Chen, Y., Li, L., Hou, C., 2023
Expanding the CRISPR/Cas genome-editing scope in Xenopus tropicalis, Shi, Z., Jiang, H., Liu, G., Shi, S., Zhang, X., Chen, Y., 2022
Disruption of tp53 leads to cutaneous nevus and melanoma formation in Xenopus tropicalis, Ran, R., Li, L., Shi, Z., Liu, G., Jiang, H., Fang, L., Xu, T., Huang, J., Chen, W., Chen, Y., 2022
Three-dimensional folding dynamics of the Xenopus tropicalis genome, Niu, L., Shen, W., Shi, Z., Tan, Y., He, N., Wan, J., Sun, J., Zhang, Y., Huang, Y., Wang, W., Fang, C., Li, J., Zheng, P., Cheung, E., Chen, Y., Li, L., Hou, C., 2021
Modeling human point mutation diseases in Xenopus tropicalis with a modified CRISPR/Cas9 system, Shi, Z., Xin, H., Tian, D., Lian, J., Wang, J., Liu, G., Ran, R., Shi, S., Zhang, Z., Shi, Y., Deng, Y., Hou, C., Chen, Y., 2019
Customized one-step preparation of sgRNA transcription templates via overlapping PCR Using short primers and its application in vitro and in vivo gene editing, Hu, Z., Wang, L., Shi, Z., Jiang, J., Li, X., Chen, Y., Li, K., Luo, D., 2019
EphA7 regulates claudin6 and pronephros development in Xenopus, Sun, J., Wang, X., Shi, Y., Li, J., Li, C., Shi, Z., Chen, Y., Mao, B., 2018
Ligase IV inhibitor SCR7 enhances gene editing directed by CRISPR-Cas9 and ssODN in human cancer cells, Hu, Z., Shi, Z., Guo, X., Jiang, B., Wang, G., Luo, D., Chen, Y., Zhu, Y. S., 2018
Targeted integration of genes in Xenopus tropicalis, Shi, Z., Tian, D., Xin, H., Lian, J., Guo, X., Chen, Y., 2017
Efficient genome editing of genes involved in neural crest development using the CRISPR/Cas9 system in Xenopus embryos, Liu, Z., Cheng, T. T., Shi, Z., Liu, Z., Lei, Y., Wang, C., Shi, W., Chen, X., Qi, X., Cai, D., Feng, B., Deng, Y., Chen, Y., Zhao, H., 2016
Targeted gene disruption in Xenopus laevis using CRISPR/Cas9, Wang, F., Shi, Z., Cui, Y., Guo, X., Shi, Y. B., Chen, Y., 2015
Heritable CRISPR/Cas9-mediated targeted integration in Xenopus tropicalis, Shi, Z., Wang, F., Cui, Y., Liu, Z., Guo, X., Zhang, Y., Deng, Y., Zhao, H., Chen, Y., 2015
Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis, Guo, X., Zhang, T., Hu, Z., Zhang, Y., Shi, Z., Wang, Q., Cui, Y., Wang, F., Zhao, H., Chen, Y., 2014

Zygotic Genome Activation Maternal Factors Embryonic Hybrid Lethality Whole-Genome Regulatory Elements Regenerative Capacity Xenopus Gene Editing Crispr/Cas9 Genetic Engineering Disease Modeling

Jiayu Chen - Tongji University

Yu Yong - Tongji University

Jiqin Zhang - East China Normal University

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