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Xianqing Huang
Life Science
Shanghai Jiao Tong University
Shanghai
Language: Chinese, English
Antibiotic Synthesis
Pseudomonas
Molecular Regulation
Metabolic Engineering
Global Networks
Secondary Metabolism
Microbial Pesticides
High-Value Products
Biotechnology
Bioengineering
Areas of Focus
- Molecular regulation mechanisms, networks, and engineering of antibiotic synthesis in Pseudomonas
- Global regulation networks and metabolic engineering of primary and secondary metabolism in microbes
- Application and development of microbial-derived pesticides and other high-value products
Work Experience
- 2005 - Present: Shanghai Jiao Tong University - Associate Professor
Academic Background & Achievements
- 2005 - PhD in Biochemistry and Molecular Biology from Shanghai Jiao Tong University
- Led 1 National High-tech R&D Program (863 Program) and 3 National Natural Science Foundation projects
Publications
- Lon protease downregulates phenazine-1-carboxamide biosynthesis by degrading the quorum sensing signal synthase PhzI and exhibits negative feedback regulation of Lon itself in Pseudomonas chlororaphis HT66, Zheng Wang, Xianqing Huang *, Malik Jan, Deyu Kong, Wei Wang, Xuehong Zhang *, 2021
- GacS/GacA activates pyoluteorin biosynthesis through Gac/Rsm-RsmE cascade and RsmA/RsmE-driven feedback loop in Pseudomonas protegens H78, Zheng Wang, Xianqing Huang *, Yujie Liu, Guohuan Yang, Yang Liu, Xuehong Zhang, 2017
- The Lon protease negatively regulates pyoluteorin biosynthesis through the Gac/Rsm-RsmE cascade and directly degrades the transcriptional activator PltR in Pseudomonas protegens H78, Zheng Wang, Xianqing Huang *, Chenxi Nie, Tao Xiang, Xuehong Zhang *, 2022
- The global regulator Hfq exhibits far more extensive and intensive regulation than Crc in Pseudomonas protegens H78, Zheng Wang, Xianqing Huang *, Malik Jan, Deyu Kong, Jingwen Pan, Xuehong Zhang *, 2021
- The (p)ppGpp-mediated stringent response regulatory system globally inhibits primary metabolism and activates secondary metabolism in Pseudomonas Protegens H78, Lingyu Wu, Zheng Wang, Yejun Guan, Xianqing Huang *, Huimin Shi, Yujie Liu, Xuehong Zhang, 2020
- Pleiotropic control of antibiotic biosynthesis, flagellar operon expression, biofilm formation, and carbon source utilization by RpoN in Pseudomonas protegens H78, Yujie Liu, Huimin Shi, Zheng Wang, Xianqing Huang*, Xuehong Zhang, 2018
- Improvement of pyoluteorin production in Pseudomonas protegens H78 through engineering its biosynthetic and regulatory pathways, Huimin Shi, Xianqing Huang*, Zheng Wang, Yejun Guan, Xuehong Zhang, 2019
- Global control of GacA in secondary metabolism, primary metabolism, secretion systems, and motility in the rhizobacterium Pseudomonas aeruginosa M18, Xue Wei, Xianqing Huang *, Lulu Tang, Daqiang Wu, Yuquan Xu *, 2013
- The RNA chaperone Hfq regulates antibiotic biosynthesis in the rhizobacterium Pseudomonas aeruginosa M18, Guohao Wang, Xianqing Huang *, Sainan Li, Jiaofang Huang, Xue Wei, Yaqian Li, Yuquan Xu *, 2012
Awards
- 2007: First Prize of Shanghai Science and Technology Progress Award for the project 'Development and Application of Shenqinmycin'
