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Jingdan Liang
Life Science
Shanghai Jiao Tong University
Shanghai
Language: Chinese, English
Sulfur
Dna
Modification
Oligonucleotide
Drugs
Bacterial
Physiological
Mechanism
Synthesis
Research
Areas of Focus
- Sulfur modification of DNA
- Structural and mechanistic studies of important drug synthesis machinery
- Physiological modifications of DNA phosphorothioate
Work Experience
- Current: Works at the State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University
Academic Background & Achievements
- PhD from Shanghai Jiao Tong University
- Visiting scholar at the Department of Cell Biology, University of California, Berkeley (Feb 2011 - Feb 2013)
Publications
- C-N bond formation by a polyketide synthase, Wang J, Wang X, Li X, Kong L, Du Z, Li D, Gou L, Wu H, Cao W, Wang X, Lin S, Shi T, Deng Z, Wang Z, Liang J*, 2023
- Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain, Wang J, Li D, Chen L, Cao W, Kong L, Zhang W, Croll T, Deng Z, Liang J*, Wang Z, 2022
- Structural basis for the biosynthesis of Lovastatin, Wang J, Liang J, Chen L, Zhang W, Kong L, Peng C, Su C, Tang Y, Deng X*, Wang Z*, 2021
- Phosphorothioated DNA is shielded from oxidative damage, Pu T, Liang J, Mei Z, Yang Y, Wang J, Zhang W, Liang W, Zhou X, Deng Z, Wang Z, 2019
- An in vitro DNA Phosphorothioate Modification Reaction, Pu T, Mei Z, Zhang W, Liang W, Zhou X, Liang J, Deng Z, Wang Z, 2020
- Cezomycin Is Activated by CalC to Its Ester Form for Further Biosynthesis Steps in the Production of Calcimycin in Streptomyces chartreusis NRRL 3882, Wu H, Liang J, Wang J, Liang W, Gou L, Wu Q, Zhou X, Bruce IJ, Deng Z, Wang Z, 2018
- Recycling of Overactivated Acyls by a Type II Thioesterase during Calcimycin Biosynthesis in Streptomyces chartreusis NRRL 3882, Wu H, Liang J, Gou L, Wu Q, Liang W, Zhou X, Bruce IJ, Deng Z, Wang Z, 2018
- DNA Phosphorothioate Modification Plays a Role in Peroxides Resistance in Streptomyces lividans, Dai D, Du A, Xiong K, Pu T, Zhou X, Deng Z, Liang J, He X, Wang Z, 2016
- Phosphorothioate DNA as an antioxidant in bacteria, Xie X, Liang J, Pu T, Xu F, Yao F, Yang Y, Zhao Y, You D, Zhou X, Deng Z, Wang Z, 2012
- DNA modification by sulfur: analysis of the sequence recognition specificity surrounding the modification sites, Liang J, Wang Z, He X, Li J, Zhou X, Deng Z, 2007
Awards
- Pujiang Plan Special Urgent Talent
- Principal investigator for multiple National Natural Science Foundation projects, Shanghai Natural Science Foundation, Pujiang Scholar Project, Transgenic Special Project, Synthetic Biology Subproject
