Areas of Focus
- Sulfur modification of DNA and its implications in oligonucleotide drugs
- Structural and mechanistic studies of natural product synthesis machinery using cryo-EM
- Physiological significance of DNA phosphorothioate modifications
Work Experience
- Current: Works at the State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University
Academic Background & Achievements
- PhD from Shanghai Jiao Tong University
- Visiting scholar at the Department of Cell Biology, University of California, Berkeley (Feb 2011 - Feb 2013)
Publications
- C-N bond formation by a polyketide synthase, Liang J* et al., 2023
- Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain, Liang J* et al., 2022
- Structural basis for the biosynthesis of Lovastatin, Liang J et al., 2021
- Phosphorothioated DNA is shielded from oxidative damage, Liang J et al., 2019
- An in vitro DNA Phosphorothioate Modification Reaction, Liang J* et al., 2020
- Cezomycin Is Activated by CalC to Its Ester Form for Further Biosynthesis Steps in the Production of Calcimycin in Streptomyces chartreusis NRRL 3882, Liang J et al., 2018
- Recycling of Overactivated Acyls by a Type II Thioesterase during Calcimycin Biosynthesis in Streptomyces chartreusis NRRL 3882, Liang J et al., 2018
- DNA Phosphorothioate Modification Plays a Role in Peroxides Resistance in Streptomyces lividans, Liang J* et al., 2016
- Phosphorothioate DNA as an antioxidant in bacteria, Liang J et al., 2012
- DNA modification by sulfur: analysis of the sequence recognition specificity surrounding the modification sites, Liang J et al., 2007
Awards
- Pujiang Plan Special Urgent Talent
