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Zhijun Wang
Life Science
Shanghai Jiao Tong University
Shanghai
Language: Chinese, English
Synthesis
Natural Products
Cryo-Em
Protein Structure
Antibiotics
Erythromycin
Penicillin
Lovastatin
Lipid-Lowering Drugs
Cancer Treatment
Areas of Focus
- Synthetic machinery of natural products
- Cryo-EM techniques for protein structure analysis
- Synthetic machinery for antibiotics like erythromycin and penicillin
- Synthetic machinery for lovastatin and related compounds
Work Experience
- 2007 - Present - Shanghai Jiao Tong University, Microbial Metabolism National Key Laboratory
Academic Background & Achievements
- Doctorate: Microbial Metabolism National Key Laboratory
- Position at Shanghai Jiao Tong University since 2007
- Visiting Scholar at University of California, Berkeley (2011-2013)
Publications
- C-N bond formation by a polyketide synthase, Wang J, Wang X, Li X, Kong L, Du Z, Li D, Gou L, Wu H, Cao W, Wang X, Lin S, Shi T, Deng Z, Wang Z, Liang J, 2023
- Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain, Wang J, Li D, Chen L, Cao W, Kong L, Zhang W, Croll T, Deng Z, Liang J, Wang Z, 2022
- Structural basis for the biosynthesis of Lovastatin, Wang J, Liang J, Chen L, Zhang W, Kong L, Peng C, Su C, Tang Y, Deng X, Wang Z, 2021
- An in vitro DNA Phosphorothioate Modification Reaction, Pu T, Mei Z, Zhang W, Liang W, Zhou X, Liang J, Deng Z, Wang Z, 2020
- Phosphorothioated DNA is shielded from oxidative damage, Pu T, Liang J, Mei Z, Yang Y, Wang J, Zhang W, Liang W, Zhou X, Deng Z, Wang Z, 2019
- Recycling of Overactivated Acyls by a Type II Thioesterase during Calcimycin Biosynthesis in Streptomyces chartreusis NRRL 3882, Wu H, Liang J, Gou L, Wu Q, Liang W, Zhou X, Bruce IJ, Deng Z, Wang Z, 2018
- Cezomycin Is Activated by CalC to Its Ester Form for Further Biosynthesis Steps in the Production of Calcimycin in Streptomyces chartreusis NRRL 3882, Wu H, Liang J, Wang J, Liang W, Gou L, Wu Q, Zhou X, Bruce IJ, Deng Z, Wang Z, 2018
- CRISPR/dCas9-Mediated Multiplex Gene Repression in Streptomyces, Zhao Y, Li L, Zheng G, Jiang W, Deng Z, Wang Z, Lu Y, 2018
- Phosphorothioate DNA as an antioxidant in bacteria, Xie X, Liang J, Pu T, Xu F, Yao F, Yang Y, Zhao Y, You D, Zhou X, Deng Z, Wang Z, 2012
- DNA modification by sulfur: analysis of the sequence recognition specificity surrounding the modification sites, Liang J, Wang Z, He X, Li J, Zhou X, Deng Z, 2007
