Professor | You Delin | Asia Growth Partners

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Name	You Delin
Contact Information	dlyou@sjtu.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

You Delin

Contact Information

dlyou@sjtu.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Shanghai Jiao Tong University
Faculty	Life Sciences
Academic Background & Achievements	1998-2001 PhD in Biochemistry and Molecular Biology, Jilin University 2001-2003 Postdoctoral Researcher, School of Life Sciences, Peking University 2010-2011 Visiting Scholar, Department of Biological Engineering, MIT
Work Experience	2003-present - Shanghai Jiao Tong University, School of Life Sciences and Biotechnology - Associate Professor, Professor, Distinguished Professor
Awards	2008 Selected for the first Shanghai Jiao Tong University Morning Star Young Scholar Award Program (Category A) 2012 Meiji Life Science Award (Science Award), selected for Shanghai Pujiang Talent Plan

University/Lab Affiliation and Title

Shanghai Jiao Tong University

Faculty

Life Sciences

Academic Background & Achievements

1998-2001 PhD in Biochemistry and Molecular Biology, Jilin University
2001-2003 Postdoctoral Researcher, School of Life Sciences, Peking University
2010-2011 Visiting Scholar, Department of Biological Engineering, MIT

Work Experience

2003-present - Shanghai Jiao Tong University, School of Life Sciences and Biotechnology - Associate Professor, Professor, Distinguished Professor

Awards

2008 Selected for the first Shanghai Jiao Tong University Morning Star Young Scholar Award Program (Category A)
2012 Meiji Life Science Award (Science Award), selected for Shanghai Pujiang Talent Plan

Areas of Focus	DNA phosphorothioate modification Biosynthesis of microbial natural products
Publications	Quantitative mapping of DNA phosphorothioatome reveals phosphorothioate heterogeneity of low modification frequency, Li J, Chen Y, Zheng T, Kong L, Zhu S, Sun Y, Deng Z, Yang L, You D, 2019 Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps, Zheng X, Cheng Q, Yao F, Wang X, Kong L, Cao B, Xu M, Lin S, Deng Z, Chooi YH, You D, 2017 A Multifunctional Monooxygenase XanO4 Catalyzes Xanthone Formation in Xantholipin Biosynthesis via a Cryptic Demethoxylation, Kong L, Zhang W, Chooi YH, Wang L, Cao B, Deng Z, Chu Y, You D, 2016 DndEi exhibits helicase activity essential for DNA phosphorothioate modification and ATPase activity strongly stimulated by DNA substrate with a GAAC/GTTC motif, Zheng T, Jiang P, Cao B, Cheng Q, Kong L, Zheng X, Hu Q, You D, 2016 Regulation of DNA phosphorothioate modifications by the transcriptional regulator DptB in Salmonella, Cheng Q, Cao B, Yao F, Li J, Deng Z, You D, 2015 Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences, Cao B, Chen C, DeMott MS, Cheng Q, Clark TA, Xiong X, Zheng X, Butty V, Levine SS, Yuan G, Boitano M, Luong K, Song Y, Zhou X, Deng Z, Turner SW, Korlach J, You D, Wang L, Chen S, Dedon PC, 2014 Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens, Zhu T, Cheng X, Liu Y, Deng Z, You D, 2013 Unveiling the post-PKS redox tailoring steps in biosynthesis of the type II polyketide antitumor antibiotic xantholipin, Zhang W, Wang L, Kong L, Wang T, Chu Y, Deng Z, You D, 2012 Elucidation of piericidin A1 biosynthetic locus revealed a thioesterase-dependent mechanism of α-pyridone ring formation, Liu Q, Yao F, Chooi Y, Kang Q, Xu W, Li Y, Shao Y, Shi Y, Deng Z, Tang Y, You D, 2012 A novel host-specific restriction system associated with DNA backbone S-modification in Salmonella, Xu T, Yao F, Zhou X, Deng Z, You D, 2010

Areas of Focus

DNA phosphorothioate modification
Biosynthesis of microbial natural products

Publications

Quantitative mapping of DNA phosphorothioatome reveals phosphorothioate heterogeneity of low modification frequency, Li J, Chen Y, Zheng T, Kong L, Zhu S, Sun Y, Deng Z, Yang L, You D, 2019
Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps, Zheng X, Cheng Q, Yao F, Wang X, Kong L, Cao B, Xu M, Lin S, Deng Z, Chooi YH, You D, 2017
A Multifunctional Monooxygenase XanO4 Catalyzes Xanthone Formation in Xantholipin Biosynthesis via a Cryptic Demethoxylation, Kong L, Zhang W, Chooi YH, Wang L, Cao B, Deng Z, Chu Y, You D, 2016
DndEi exhibits helicase activity essential for DNA phosphorothioate modification and ATPase activity strongly stimulated by DNA substrate with a GAAC/GTTC motif, Zheng T, Jiang P, Cao B, Cheng Q, Kong L, Zheng X, Hu Q, You D, 2016
Regulation of DNA phosphorothioate modifications by the transcriptional regulator DptB in Salmonella, Cheng Q, Cao B, Yao F, Li J, Deng Z, You D, 2015
Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences, Cao B, Chen C, DeMott MS, Cheng Q, Clark TA, Xiong X, Zheng X, Butty V, Levine SS, Yuan G, Boitano M, Luong K, Song Y, Zhou X, Deng Z, Turner SW, Korlach J, You D, Wang L, Chen S, Dedon PC, 2014
Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens, Zhu T, Cheng X, Liu Y, Deng Z, You D, 2013
Unveiling the post-PKS redox tailoring steps in biosynthesis of the type II polyketide antitumor antibiotic xantholipin, Zhang W, Wang L, Kong L, Wang T, Chu Y, Deng Z, You D, 2012
Elucidation of piericidin A1 biosynthetic locus revealed a thioesterase-dependent mechanism of α-pyridone ring formation, Liu Q, Yao F, Chooi Y, Kang Q, Xu W, Li Y, Shao Y, Shi Y, Deng Z, Tang Y, You D, 2012
A novel host-specific restriction system associated with DNA backbone S-modification in Salmonella, Xu T, Yao F, Zhou X, Deng Z, You D, 2010

Dna Modification Phosphorothioate Epigenetics Biochemistry Genomic Sequencing Cell Defense Gene Expression Regulation Microbial Products Biosynthetic Pathways Natural Products

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