Upload Avatar (500 x 500)
由德林
Life Science
上海交通大学
上海
Language: 中文, 英语
Dna修饰
磷硫酰化
表观遗传学
生物化学
基因组测序
细胞防御
基因表达调控
微生物产品
生物合成途径
天然产物
Areas of Focus
- DNA磷硫酰化修饰
- 微生物天然产物的生物合成
Work Experience
- 2003-至今 - 上海交通大学生命科学技术学院 - 副教授，教授，长聘教授
Academic Background & Achievements
- 1998-2001 吉林大学，生物化学与分子生物学博士
- 2001-2003 北京大学生命科学学院，博士后
- 2010-2011 麻省理工学院生物工程系，访问学者
Publications
- Quantitative mapping of DNA phosphorothioatome reveals phosphorothioate heterogeneity of low modification frequency, Li J, Chen Y, Zheng T, Kong L, Zhu S, Sun Y, Deng Z, Yang L, You D, 2019
- Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps, Zheng X, Cheng Q, Yao F, Wang X, Kong L, Cao B, Xu M, Lin S, Deng Z, Chooi YH, You D, 2017
- A Multifunctional Monooxygenase XanO4 Catalyzes Xanthone Formation in Xantholipin Biosynthesis via a Cryptic Demethoxylation, Kong L, Zhang W, Chooi YH, Wang L, Cao B, Deng Z, Chu Y, You D, 2016
- DndEi exhibits helicase activity essential for DNA phosphorothioate modification and ATPase activity strongly stimulated by DNA substrate with a GAAC/GTTC motif, Zheng T, Jiang P, Cao B, Cheng Q, Kong L, Zheng X, Hu Q, You D, 2016
- Regulation of DNA phosphorothioate modifications by the transcriptional regulator DptB in Salmonella, Cheng Q, Cao B, Yao F, Li J, Deng Z, You D, 2015
- Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences, Cao B, Chen C, DeMott MS, Cheng Q, Clark TA, Xiong X, Zheng X, Butty V, Levine SS, Yuan G, Boitano M, Luong K, Song Y, Zhou X, Deng Z, Turner SW, Korlach J, You D, Wang L, Chen S, Dedon PC, 2014
- Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens, Zhu T, Cheng X, Liu Y, Deng Z, You D, 2013
- Unveiling the post-PKS redox tailoring steps in biosynthesis of the type II polyketide antitumor antibiotic xantholipin, Zhang W, Wang L, Kong L, Wang T, Chu Y, Deng Z, You D, 2012
- Elucidation of piericidin A1 biosynthetic locus revealed a thioesterase-dependent mechanism of α-pyridone ring formation, Liu Q, Yao F, Chooi Y, Kang Q, Xu W, Li Y, Shao Y, Shi Y, Deng Z, Tang Y, You D, 2012
- A novel host-specific restriction system associated with DNA backbone S-modification in Salmonella, Xu T, Yao F, Zhou X, Deng Z, You D, 2010
Awards
- 2008年入选首届上海交通大学晨星青年学者奖励计划(A类)
- 2012年获得明治生命科学奖（科学奖），入选上海市浦江人才计划
