Professor | 由德林 | 数字化转型顾问

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Name	由德林
Contact Information	dlyou@sjtu.edu.cn
Language ability	中文, 英语
Province	上海

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Name

由德林

Contact Information

dlyou@sjtu.edu.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	上海交通大学
Faculty	Life Sciences
Academic Background & Achievements	1998-2001 吉林大学，生物化学与分子生物学博士 2001-2003 北京大学生命科学学院，博士后 2010-2011 麻省理工学院生物工程系，访问学者
Work Experience	2003-至今 - 上海交通大学生命科学技术学院 - 副教授，教授，长聘教授
Awards	2008年入选首届上海交通大学晨星青年学者奖励计划(A类) 2012年获得明治生命科学奖（科学奖），入选上海市浦江人才计划

University/Lab Affiliation and Title

上海交通大学

Faculty

Life Sciences

Academic Background & Achievements

1998-2001 吉林大学，生物化学与分子生物学博士
2001-2003 北京大学生命科学学院，博士后
2010-2011 麻省理工学院生物工程系，访问学者

Work Experience

2003-至今 - 上海交通大学生命科学技术学院 - 副教授，教授，长聘教授

Awards

2008年入选首届上海交通大学晨星青年学者奖励计划(A类)
2012年获得明治生命科学奖（科学奖），入选上海市浦江人才计划

Areas of Focus	DNA磷硫酰化修饰微生物天然产物的生物合成
Publications	Quantitative mapping of DNA phosphorothioatome reveals phosphorothioate heterogeneity of low modification frequency, Li J, Chen Y, Zheng T, Kong L, Zhu S, Sun Y, Deng Z, Yang L, You D, 2019 Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps, Zheng X, Cheng Q, Yao F, Wang X, Kong L, Cao B, Xu M, Lin S, Deng Z, Chooi YH, You D, 2017 A Multifunctional Monooxygenase XanO4 Catalyzes Xanthone Formation in Xantholipin Biosynthesis via a Cryptic Demethoxylation, Kong L, Zhang W, Chooi YH, Wang L, Cao B, Deng Z, Chu Y, You D, 2016 DndEi exhibits helicase activity essential for DNA phosphorothioate modification and ATPase activity strongly stimulated by DNA substrate with a GAAC/GTTC motif, Zheng T, Jiang P, Cao B, Cheng Q, Kong L, Zheng X, Hu Q, You D, 2016 Regulation of DNA phosphorothioate modifications by the transcriptional regulator DptB in Salmonella, Cheng Q, Cao B, Yao F, Li J, Deng Z, You D, 2015 Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences, Cao B, Chen C, DeMott MS, Cheng Q, Clark TA, Xiong X, Zheng X, Butty V, Levine SS, Yuan G, Boitano M, Luong K, Song Y, Zhou X, Deng Z, Turner SW, Korlach J, You D, Wang L, Chen S, Dedon PC, 2014 Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens, Zhu T, Cheng X, Liu Y, Deng Z, You D, 2013 Unveiling the post-PKS redox tailoring steps in biosynthesis of the type II polyketide antitumor antibiotic xantholipin, Zhang W, Wang L, Kong L, Wang T, Chu Y, Deng Z, You D, 2012 Elucidation of piericidin A1 biosynthetic locus revealed a thioesterase-dependent mechanism of α-pyridone ring formation, Liu Q, Yao F, Chooi Y, Kang Q, Xu W, Li Y, Shao Y, Shi Y, Deng Z, Tang Y, You D, 2012 A novel host-specific restriction system associated with DNA backbone S-modification in Salmonella, Xu T, Yao F, Zhou X, Deng Z, You D, 2010

Areas of Focus

DNA磷硫酰化修饰
微生物天然产物的生物合成

Publications

Quantitative mapping of DNA phosphorothioatome reveals phosphorothioate heterogeneity of low modification frequency, Li J, Chen Y, Zheng T, Kong L, Zhu S, Sun Y, Deng Z, Yang L, You D, 2019
Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps, Zheng X, Cheng Q, Yao F, Wang X, Kong L, Cao B, Xu M, Lin S, Deng Z, Chooi YH, You D, 2017
A Multifunctional Monooxygenase XanO4 Catalyzes Xanthone Formation in Xantholipin Biosynthesis via a Cryptic Demethoxylation, Kong L, Zhang W, Chooi YH, Wang L, Cao B, Deng Z, Chu Y, You D, 2016
DndEi exhibits helicase activity essential for DNA phosphorothioate modification and ATPase activity strongly stimulated by DNA substrate with a GAAC/GTTC motif, Zheng T, Jiang P, Cao B, Cheng Q, Kong L, Zheng X, Hu Q, You D, 2016
Regulation of DNA phosphorothioate modifications by the transcriptional regulator DptB in Salmonella, Cheng Q, Cao B, Yao F, Li J, Deng Z, You D, 2015
Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences, Cao B, Chen C, DeMott MS, Cheng Q, Clark TA, Xiong X, Zheng X, Butty V, Levine SS, Yuan G, Boitano M, Luong K, Song Y, Zhou X, Deng Z, Turner SW, Korlach J, You D, Wang L, Chen S, Dedon PC, 2014
Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens, Zhu T, Cheng X, Liu Y, Deng Z, You D, 2013
Unveiling the post-PKS redox tailoring steps in biosynthesis of the type II polyketide antitumor antibiotic xantholipin, Zhang W, Wang L, Kong L, Wang T, Chu Y, Deng Z, You D, 2012
Elucidation of piericidin A1 biosynthetic locus revealed a thioesterase-dependent mechanism of α-pyridone ring formation, Liu Q, Yao F, Chooi Y, Kang Q, Xu W, Li Y, Shao Y, Shi Y, Deng Z, Tang Y, You D, 2012
A novel host-specific restriction system associated with DNA backbone S-modification in Salmonella, Xu T, Yao F, Zhou X, Deng Z, You D, 2010

Dna修饰磷硫酰化表观遗传学生物化学基因组测序细胞防御基因表达调控微生物产品生物合成途径天然产物

由德林 - 上海交通大学

孙鲁阳 - 中国科学院大学

杨云强 - 中国科学院大学

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