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Yong Zhang
Life Science
Shanghai Jiao Tong University
Shanghai
Language: Chinese, English
Enzyme Design
Molecular Dynamics
Biocatalysis
Substrate Specificity
Protein Engineering
X-Ray Crystallography
Biochemistry
Molecular Genetics
Cascade Systems
Inhibitor Synthesis
Areas of Focus
- Enzyme molecular design and cascade enzyme system assembly
- Inhibitor design and synthesis
Work Experience
- Current - Shanghai Jiao Tong University - Associate Researcher
Academic Background & Achievements
- Bachelor: Xinjiang University
- Master: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- PhD: Fudan University, Molecular Genetics and Biochemistry
- Postdoctoral Researcher: University of Texas at Austin
- Visiting Scholar: Michigan State University
Publications
- Ordered Coimmobilization of Multimeric Enzyme Arrays with Enhanced Biocatalytic Cascade Performance, Mohamed Yassin Ali, Qing Chang, Yuerong Su, Jinhong Wu, Quande Yan, Liang Yin, Yong Zhang*, and Yan Feng*, 2021
- Highly Efficient Biosynthesis of Glycyrrhetinic Acid Glycoside Derivatives Using an Artificial Biocatalyst Cascade, Mohamed Yassin Ali, Qing Chang, Guo Xiang, Yong Zhang*, Yan Feng*, 2021
- Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method, Yumeng Tan, Yong Zhang, Yunbin Han, Hao Liu, Haifeng Chen, Fuqiang Ma, Stephen G Withers, Yan Feng, Guangyu Yang*, 2019
- Structure of an Endogalactosylceramidase from Rhodococcus hoagii 103S Reveals the Molecular Basis of its Substrate Specificity, Liuqing Chen, Qing Chang, Guangyu Yang, Yong Zhang*, Yan Feng*, 2019
- Self-Assembled Multimeric-Enzyme Nanoreactor for Robust and Efficient Biocatalysis, Liang Yin, Xiang Guo, Lu Liu, Yong Zhang*, Yan Feng*, 2018
- Stepwise Loop Insertion Strategy for Active Site Remodeling to Generate Novel Enzyme Functions, Md Anarul Hoque, Yong Zhang, Liuqing Chen, Guangyu Yang, Mst Afroza Khatun, Haifeng Chen, Liu Hao, Yan Feng*, 2017
- Structure features of GH10 xylanase from Caldicellulosiruptor bescii: implication for its thermophilic adaption and substrate binding preference, Yong Zhang, Jiao An, Guangyu Yang, Xiaofei Zhang, Yuan Xie, Liuqing Chen, Yan Feng*, 2016
- Synthesis, biological evaluation and molecular docking of 2-phenyl- benzo[d] oxazole- 7-carboxamide derivatives as potential Staphylococcus aureus sortaseA inhibitors, Yong Zhang, Jian Bao, Xinxian Deng, Wan He, Jiajun Fan, Lei Fu*, 2016
- Synthesis, biological evaluation and molecular docking analysis of 2-phenyl-benzofuran-3-carboxamide as a potential inhibitors of Sortase A, Wan He, Yong Zhang, Jian Bao, Xinxian Deng, Jennifer Batara, Shawn Casey, Faqin Jiang*, Lei Fu*, 2016
- Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue, Yong Zhang, Mengmeng Zhang and Yan Zhang*, 2011
Awards
- 2019: Jiangsu Province Yangzhong Innovative Talent 'Jiang Yan Plan'
