Professor | Daochun Kong | Asia Growth Partners

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Name	Daochun Kong
Contact Information	{'en': 'Email: kongdc (AT) pku.edu.cn, Office Phone: 62760866, Lab Phone: 62767127', 'zh': '电子邮件：kongdc (AT) pku.edu.cn，办公室电话：62760866，实验室电话：62767127', 'de': 'E-Mail: kongdc (AT) pku.edu.cn, Bürotelefon: 62760866, Labortelefon: 62767127'}
Language ability	English, Chinese
Province	Beijing

Upload Avatar (500 x 500)

Name

Daochun Kong

Contact Information

{'en': 'Email: kongdc (AT) pku.edu.cn, Office Phone: 62760866, Lab Phone: 62767127', 'zh': '电子邮件：kongdc (AT) pku.edu.cn，办公室电话：62760866，实验室电话：62767127', 'de': 'E-Mail: kongdc (AT) pku.edu.cn, Bürotelefon: 62760866, Labortelefon: 62767127'}

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Life Sciences
Academic Background & Achievements	1998-2000 Postdoctoral Fellow, The Memorial Sloan-Kettering Cancer Center 1995-1998 Postdoctoral Fellow, Harvard Medical School, Department of Biochemistry and Molecular Pharmacology 1990-1994 PhD, Temple University Medical School, Department of Biochemistry 1986-1989 Master's, Shanghai Institute of Biochemistry, Chinese Academy of Sciences 1979-1983 Bachelor's, Lanzhou University, Department of Biology
Work Experience	2005-Present Professor, School of Life Sciences, Peking University 2000-2005 National Institutes of Health, USA 1989-1990 Shanghai Pharmaceutical Industry Research Institute, State Administration of Medicine 1983-1986 Lanzhou Institute of Biological Products, Ministry of Health

University/Lab Affiliation and Title

Peking University

Faculty

Life Sciences

Academic Background & Achievements

1998-2000 Postdoctoral Fellow, The Memorial Sloan-Kettering Cancer Center
1995-1998 Postdoctoral Fellow, Harvard Medical School, Department of Biochemistry and Molecular Pharmacology
1990-1994 PhD, Temple University Medical School, Department of Biochemistry
1986-1989 Master's, Shanghai Institute of Biochemistry, Chinese Academy of Sciences
1979-1983 Bachelor's, Lanzhou University, Department of Biology

Work Experience

2005-Present Professor, School of Life Sciences, Peking University
2000-2005 National Institutes of Health, USA
1989-1990 Shanghai Pharmaceutical Industry Research Institute, State Administration of Medicine
1983-1986 Lanzhou Institute of Biological Products, Ministry of Health

Areas of Focus	Eukaryotic cell DNA replication initiation Cellular regulation maintaining DNA replication fork stability Checkpoint regulation Chromsfork regulation DNA homologous recombination DNA single and double strand break repair Chromatin structure formation
Publications	Cellular regulation and stability of DNA replication forks in eukaryotic cells, Xizhou Li, Lu Wang, Xiaoqin Liu, Zeqi Zheng, Daochun Kong, 2022 RNA polymerase III directly participates in DNA homologous recombination, Sijie Liu, Xizhou Li, Xiaoqin Liu, Jingna Wang, Lingyan Li, Daochun Kong, 2022 Synthetic lethality between TP53 and ENDOD1, Zizhi Tang, Ming Zeng, Xiaojun Wang, Chang Guo, Peng Yue, Xiaohu Zhang, Huiqiang Lou, Jun Chen, Dezhi Mu, Daochun Kong, Antony M Carr, Cong Liu, 2022 A direct role of RNA polymerase III and RNA in DNA homologous recombination, Sijie Liu & Daochun Kong, 2021 A Recently Discovered Essential Factor for DNA Homologous Recombination: RNA Polymerase III, Sijie Liu, Xiaoqin Liu, Daochun Kong, 2021 The intra-S phase checkpoint directly regulates replication elongation to preserve the integrity of stalled replisomes, Yang Liu, Lu Wang, Xin Xu, Yue Yuan, Bo Zhang, Zeyang Li, Yuchen Xie, Rui Yan, Zeqi Zheng, Jianguo Ji, Johanne M Murray, Antony M Carr, Daochun Kong, 2021 RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination, Sijie Liu, Yu Hua, Jingan Wang, Lingyan Li, Junjie Yuan, Bo Zhang, Ziyang Wang, Jianguo Ji, Daochun Kong, 2021 Girdin: an essential component of pre-replicative complex in human cells, Lihong Wu, Yu Hua, Feiran Chang, Daochun Kong, 2019 Replication fork stalling elicits chromatin compaction for the stability of stalling replication forks, Gang Feng, Yue Yuan, Zeyang Li, Lu Wang, Bo Zhang, Jiechen Luo, Jianguo Ji, Daochun Kong, 2019 Gpn2 and Rba50 Directly Participate in the Assembly of the Rpb3 Subcomplex in the Biogenesis of RNA Polymerase II, Fanli Zeng, Yu Hua, Xiaoqin Liu, Sijie Liu, Kejing Lao, Ze Zhang, Daochun Kong, 2018 Sap1 is a replication initiation factor essential for the assembly of pre-replicative complex in the fission yeast Schizosaccharomyces pombe, Ling Guan, Peng He, Fang Yang, Yuan Zhang, Yunfei Hu, Jienv Ding, Yu Hua, Yi Zhang, Qiong Ye, Jiazhi Hu, Tao Wang, Changwen Jin, Daochun Kong, 2017 Direct Visualization of RNA-DNA Primer Removal from Okazaki Fragments Provides Support for Flap Cleavage and Exonucleolytic Pathways in Eukaryotic Cells, Bochao Liu, Jiazhi Hu, Jingna Wang, Daochun Kong, 2017 Cdc24 Is Essential for Long-range End Resection in the Repair of Double-stranded DNA Breaks, Huimin Zhang, Yu Hua, Rui Li, Daochun Kong, 2016 CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection, Ming Zeng, Laifeng Ren, Ken'Ichi Mizuno, Konstantinos Nestoras, Haibin Wang, Zizhi Tang, Liandi Guo, Daochun Kong, Qiwen Hu, Qun He, Lilin Du, Antony M. Carr, Cong Liu, 2016 Mechanism of chromosomal DNA replication initiation and replication fork stabilization in eukaryotes, Lihong Wu, Yang Liu, Daochun Kong, 2014 The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing, Jiazhi Hu, Lei Sun, Fenfen Shen, Yufei Chen, Yu Hua, Yang Liu, Mian Zhang, Yiren Hu, Qingsong Wang, Wei Xu, Fei Sun, Jianguo Ji, Johanne M. Murray, Antony M. Carr, Daochun Kong, 2012

Areas of Focus

Eukaryotic cell DNA replication initiation
Cellular regulation maintaining DNA replication fork stability
Checkpoint regulation
Chromsfork regulation
DNA homologous recombination
DNA single and double strand break repair
Chromatin structure formation

Publications

Cellular regulation and stability of DNA replication forks in eukaryotic cells, Xizhou Li, Lu Wang, Xiaoqin Liu, Zeqi Zheng, Daochun Kong, 2022
RNA polymerase III directly participates in DNA homologous recombination, Sijie Liu, Xizhou Li, Xiaoqin Liu, Jingna Wang, Lingyan Li, Daochun Kong, 2022
Synthetic lethality between TP53 and ENDOD1, Zizhi Tang, Ming Zeng, Xiaojun Wang, Chang Guo, Peng Yue, Xiaohu Zhang, Huiqiang Lou, Jun Chen, Dezhi Mu, Daochun Kong, Antony M Carr, Cong Liu, 2022
A direct role of RNA polymerase III and RNA in DNA homologous recombination, Sijie Liu & Daochun Kong, 2021
A Recently Discovered Essential Factor for DNA Homologous Recombination: RNA Polymerase III, Sijie Liu, Xiaoqin Liu, Daochun Kong, 2021
The intra-S phase checkpoint directly regulates replication elongation to preserve the integrity of stalled replisomes, Yang Liu, Lu Wang, Xin Xu, Yue Yuan, Bo Zhang, Zeyang Li, Yuchen Xie, Rui Yan, Zeqi Zheng, Jianguo Ji, Johanne M Murray, Antony M Carr, Daochun Kong, 2021
RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination, Sijie Liu, Yu Hua, Jingan Wang, Lingyan Li, Junjie Yuan, Bo Zhang, Ziyang Wang, Jianguo Ji, Daochun Kong, 2021
Girdin: an essential component of pre-replicative complex in human cells, Lihong Wu, Yu Hua, Feiran Chang, Daochun Kong, 2019
Replication fork stalling elicits chromatin compaction for the stability of stalling replication forks, Gang Feng, Yue Yuan, Zeyang Li, Lu Wang, Bo Zhang, Jiechen Luo, Jianguo Ji, Daochun Kong, 2019
Gpn2 and Rba50 Directly Participate in the Assembly of the Rpb3 Subcomplex in the Biogenesis of RNA Polymerase II, Fanli Zeng, Yu Hua, Xiaoqin Liu, Sijie Liu, Kejing Lao, Ze Zhang, Daochun Kong, 2018
Sap1 is a replication initiation factor essential for the assembly of pre-replicative complex in the fission yeast Schizosaccharomyces pombe, Ling Guan, Peng He, Fang Yang, Yuan Zhang, Yunfei Hu, Jienv Ding, Yu Hua, Yi Zhang, Qiong Ye, Jiazhi Hu, Tao Wang, Changwen Jin, Daochun Kong, 2017
Direct Visualization of RNA-DNA Primer Removal from Okazaki Fragments Provides Support for Flap Cleavage and Exonucleolytic Pathways in Eukaryotic Cells, Bochao Liu, Jiazhi Hu, Jingna Wang, Daochun Kong, 2017
Cdc24 Is Essential for Long-range End Resection in the Repair of Double-stranded DNA Breaks, Huimin Zhang, Yu Hua, Rui Li, Daochun Kong, 2016
CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection, Ming Zeng, Laifeng Ren, Ken'Ichi Mizuno, Konstantinos Nestoras, Haibin Wang, Zizhi Tang, Liandi Guo, Daochun Kong, Qiwen Hu, Qun He, Lilin Du, Antony M. Carr, Cong Liu, 2016
Mechanism of chromosomal DNA replication initiation and replication fork stabilization in eukaryotes, Lihong Wu, Yang Liu, Daochun Kong, 2014
The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing, Jiazhi Hu, Lei Sun, Fenfen Shen, Yufei Chen, Yu Hua, Yang Liu, Mian Zhang, Yiren Hu, Qingsong Wang, Wei Xu, Fei Sun, Jianguo Ji, Johanne M. Murray, Antony M. Carr, Daochun Kong, 2012

Replication Eukaryotic Dna Cell Regulation Stability Checkpoint Chromsfork Recombination Repair Chromatin

Chengqi Yi - Peking University

Ping Zhu - University of Chinese Academy of Sciences

Yuejin Hua - Zhejiang University

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