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Jun Liu
Life Science
Peking University
Beijing
Language: Chinese, English
Rna
Epigenetics
Chromatin
Gene Transcription
Ncrna
Degradation
Cell Nucleus
Biomolecular
Phase Transition
Regulatory Mechanisms
Areas of Focus
- Molecular regulatory mechanisms of RNA epigenetic modifications on chromatin structure and gene transcription
- Molecular regulatory mechanisms of ncRNA degradation within the cell nucleus
- Regulatory mechanisms of RNA epigenetic modifications on biomolecular phase transitions
Work Experience
- 2020.9-present: Researcher, Peking University-Tsinghua University Center for Life Sciences
- 2020.9-present: Researcher, School of Life Sciences, Peking University
- 2015.11-2020.8: Postdoctoral Fellow, Department of Chemistry, University of Chicago
Academic Background & Achievements
- 2010-2015: PhD in Chemical Biology, Peking University
- 2006-2010: Bachelor of Science in Chemistry, Peking University
Publications
- METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity, Dou, X. Y., Huang, L. L., Xiao, Y., Liu, C., Li, Y. N., Zhang, X. N., Yu, L. S., Zhao, R., Yang, L., Chen, C., Yu, X. B., Gao, B. Y., Qi, M. J., Gao, Y. W., Shen, B., Sun, S. Y., He, C., Liu, J., 2023
- N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription, Liu, J., Dou, X. Y., Chen, C. Y., Chen, C., Liu, C., Xu, M. M., Zhao, S. Q., Shen, B., Gao, Y. W., Han, D. L., He, C., 2020
- Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer, Wang, M., Liu, J., Zhao, Y., He, R., Xu, X., Guo, X., Li, X., Xu, S., Miao, J., Guo, J., Zhang, H., Gong, J., Zhu, F., Tian, R., Shi, C., Peng, F., Feng, Y., Yu, S., Xie, Y., Jiang, J., Li, M., Wei, W., He, C., Qin, R., 2020
- YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma, Hou, J., Zhang, H., Liu, J., Zhao, Z., Wang, J., Lu, Z., Hu, B., Zhou, J., Zhao, Z., Feng, M., Zhang, H., Shen, B., Huang, X., Sun, B., Smyth, M., He, C., Xia, Q., 2019
- Anti-tumor immunity controlled through mRNA m6A and YTHDF1 in dendritic cells, Han, D., Liu, J., Chen, C., Dong, L., Huang, X., Liu, Y., Wang, J., Dougherty, U., Bissonnette, B., Shen, B., Weichselbaum, R., Xu, M., He, C., 2019
- m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer, Liu, J., Eckert, M., Harada, B., Liu, S., Lu, Z., Yu, K., Tienda, S., Chryplewicz, A., Zhu, A., Yang, Y., Huang, J., Chen, S., Xu, Z., Leng, X., Yu, X., Cao, J., Zhang, Z., Liu, J., Lengyel, E., He, C., 2018
- VIRMA mediates preferential m6A mRNA methylation in 3`UTR and near stop codon and associates with alternative polyadenylation, Yue, Y., Liu, J., Cui, X., Cao, J., Luo, G., Zhang, Z., Gao, M., Shu, X., Ma, H., Wang, F., Shen, B., Wang, Y., Feng, X., He, C., Liu, J., 2018
Awards
- Bayer Scholar, 2022
- Peking University Boya Young Scholar, 2022
- Yifang Scholar, 2021
- Beijing Science and Technology Rising Star, 2021
