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Yan Song
Life Science
Peking University
Beijing
Language: English, Chinese
Neural Stem Cells
Fate Determination
Molecular Mechanisms
Neurodevelopment
Gene Expression
Brain Development
Cell Differentiation
Transcription Factors
Chromatin Remodeling
Signal Transduction
Areas of Focus
- Neural stem cell fate determination
- Molecular mechanisms of neurodevelopment
- Gene expression programs in brain development
Work Experience
- 2023-Present Vice Dean (Undergraduate Teaching), School of Life Sciences, Peking University
- 2013-Present Researcher, School of Life Sciences, Peking University
- 2019-Present Researcher, Peking University-Tsinghua University Center for Life Sciences (CLS)
- 2013-2018 Young Scholar, Peking University-Tsinghua University Center for Life Sciences (CLS)
- 2011-2012 Associate Researcher, Department of Pathology, Stanford University
- 2006-2011 Postdoctoral Fellow, Department of Pathology, Stanford University
Academic Background & Achievements
- 2001-2006 PhD in Molecular Genetics, Duke University
- 1996-2000 Bachelor of Science in Cell Genetics, Peking University
Publications
- It takes two to tango: The dance of cell fate specification, Song Y., 2022
- Mitotic implantation of a transcription factor via phase separation drives terminal neuronal differentiation, Liu X., Shen J., Xie L., Wei Z., Wong C., Li Y., Zheng X., Li P., Song Y., 2020
- The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking, Li B., Wong C., Gao S.M., Zhang R., Sun R., Li Y., Song Y., 2018
- Temporospatial induction of homeodomain gene cut dictates natural lineage reprogramming, Xu K., Liu X., Wang Y., Wong C., Song Y., 2018
- A genetically-encoded fluorescent acetylcholine indicator for in vitro and in vivo studies, Jing M., Zhang P., Wang G., Jiang H., Mesik L., Feng J., Wang S., Looby J., Guagliardo N.A., Langma L.W., Lu J., Zuo Y., Talmage D.A., Role L.W., Barrett P.Q., Zhang L.I., Luo M., Song Y., Zhu J., Li Y., 2018
- The super elongation complex drives neural stem cell fate commitment, Liu K., Shen D., Shen J., Gao S.M., Li B., Wong C., Feng W., Song Y., 2017
- Faster, Higher, Stronger: Timely and robust cell fate/identity commitment in stem cell lineages, Liu K., Xu K., Song Y., 2019
- The bantam microRNA acts through Numb to exert cell growth control and feedback regulation of Notch in tumor-forming stem cells in the Drosophila brain, Wu Y.C., Lee K.S., Song Y., Gehrke S., Lu B., 2017
- Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway, Lee K.S., Wu Z., Song Y., Mitra S.S., Feroze A.H., Cheshier S.H., Lu B., 2013
- Interaction of Notch signaling modulator Numb with α-Adaptin regulates endocytosis of Notch pathway components and cell fate determination of neural stem cells, Song Y., Lu B., 2012
- dp53 restrains ectopic neural stem cell formation in the Drosophila brain in a non-apoptotic mechanism involving Archipelago and Cyclin E, Ouyang Y., Song Y., Lu B., 2011
- Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila, Song Y., Lu B., 2011
- E(nos)/CG4699 required for nanos function in the female germ line of Drosophila, Yu L., Song Y., Wharton R.P., 2010
- The molecular chaperone Hsp90 is required for mRNA localization in Drosophila melanogaster embryos, Song Y., Fee L., Lee T., Wharton R.P., 2007
Awards
- 2024 Peking University Outstanding Undergraduate Thesis Advisor Award
- 2023 Most Popular Teacher Award, School of Life Sciences, Peking University
- 2023 Peking University Teaching Excellence Award
- 2023 Peking University 'Model Class Collective' Class Teacher
- 2022 Ministry of Education Top Student Training Program 2.0 Outstanding Teacher Award
- 2022 Peking University Outstanding Undergraduate Research Training Advisor Award
- 2021 Invited Speaker Award at the 3rd Young Frontiers Forum in Neurocell Biology
- 2019 Elected to the Early Career Advisory Board of the Journal of Cell Biology
- 2016 Most Popular Teacher Award, School of Life Sciences, Peking University
- 2015 Second Prize in Peking University Young Teacher Teaching Skills Competition
- 2015 Peking University Teaching Excellence Award
- 2006 Stanford University Medical School Dean's Postdoctoral Fellowship, USA
- 2005 Keystone Symposium Abstract Award, USA
- 2002-2006 Howard Hughes Medical Institute (HHMI) PhD Scholarship, USA
