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Shiqiang Wang
Life Science
Peking University
Beijing
Language: Chinese, English
Calcium
Channels
Electrophysiology
Cryo-Em
Structural Biology
Calcium Signals
Transcriptional Regulation
Cardiac Diseases
Autonomic Nervous System
Hibernation
Areas of Focus
- Calcium channels and channel-type calcium signaling proteins electrophysiology
- Calcium signaling related proteins cryo-electron microscopy structural biology
- Spatial and temporal dynamics and molecular mechanisms of localized calcium signals (calcium sparks, calcium quarks)
- Transcriptional regulation mechanisms of cellular calcium homeostasis and calcium signaling
- Molecular mechanisms and early intervention strategies for cellular calcium disorders and cardiac diseases
- Autonomic nervous system regulation of cardiomyocyte calcium homeostasis and calcium signaling
- Development, regeneration, and organoid simulation of the heart and its neural innervation
- Cellular calcium homeostasis and metabolic regulation mechanisms of hibernating animals and artificial induction of hibernation
Work Experience
- 2013 - Present: Associate Dean, School of Life Sciences, Peking University
- 2011 - 2018: Director, National Laboratory of Membrane Biology
- 2003 - Present: Professor, School of Life Sciences, Peking University
- 2002 - 2010: Deputy Director, National Laboratory of Biomembrane and Membrane Biotechnology, Peking University
- 1999 - 2003: Associate Professor, School of Life Sciences, Peking University
- 1994 - 1999: Lecturer, School of Life Sciences, Peking University
- 1990 - 1994: Teaching Assistant, Department of Biology, Peking University
Academic Background & Achievements
- 1999 - 2003: Postdoctoral Fellow, National Institutes of Health (NIH)
- 1992 - 1998: PhD in Physiology, Peking University
- 1986 - 1990: Bachelor of Science in Physiology and Biophysics, Peking University
Publications
- Transcriptional regulation of intermolecular Ca2+ signaling in ground squirrel cardiomyocytes: the myocardin- junctophilin axis, Yang L, Li RC, Xiang B, Li YC, Wang LP, Guo YB, Liang JH, Wang XT, Hou T, Xing X, Zhou ZQ, Ye H, Feng RQ, Lakatta EG, Chai Z, Wang SQ, 2021
- Nanobar Array Assay Revealed Complementary Roles of BIN1 Splice Isoforms in Cardiac T-Tubule Morphogenesis, Li LL, Guo QJ, Luo HY, Liang JH, Yang Y, Xing X, Li HT, Han J, Shen S, Li H, Ye HH, Wu HD, Cui BX, Wang SQ, 2020
- Compartmentalized β1-adrenergic signaling synchronizes excitation-contraction coupling without modulating individual Ca2+ sparks in healthy and hypertrophied cardiomyocytes, Yang HQ, Zhou P, Wang LP, Zhao YT, Ren YJ, Guo YB, Xu M, Wang SQ, 2020
- β2-Adrenergic Stimulation Compartmentalizes β1 Signaling into Nanoscale Local Domains by Targeting the C-Terminus of β1-Adrenoceptors, Yang HQ, Wang LP, Gong Y, Fan XX, Zhu SY, Wang XT, Wang YP, Li LL, Xing X, Liu XX, Ji GS, Hou T, Zhang Y, Xiao RP, Wang SQ, 2019
- Sensitized signaling between L-type Ca2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes, Zhao YT, Guo YB, Gu L, Fan XX, Yang HQ, Chen Z, Zhou P, Yuan Q, Ji G, Wang SQ, 2017
- TRPM7 Senses Mechanical Stimulation Inducing Osteogenesis in Human Bone Marrow Mesenchymal Stem Cells, Xiao E, Yang H, Gan YH, Duan DH, He LH, Guo Y, Wang SQ, Zhang Y, 2015
- Imaging Ca2+ Nanosparks in Heart with a New Targeted Biosensor, Shang W, Lu F, Sun T, Xu J, Li LL, Wang Y, Wang G, Chen L, Wang X, Cannell MB, Wang SQ, Cheng H, 2014
- In Vivo Suppression of MicroRNA-24 Prevents the Transition Toward Decompensated Hypertrophy in Aortic-Constricted Mice, Li RC, Tao J
Awards
- Peking University Top Ten Teachers Award, 2019
- National Natural Science Award, Second Class, 2017
- Ministry of Education Science and Technology Award, First Class, 2016
- Most Favorite Teacher, School of Life Sciences, 2016
- National Outstanding Science and Technology Worker, 2016
- National 'Ten Thousand Talents Plan' Leading Talent in Science and Technology Innovation, 2016
- Beijing Outstanding Teacher, 2013
- Government Special Allowance of the State Council, 2011
- New Century Millions of Talents Project, National Candidate, 2009
- Ministry of Health Cardiovascular Disease Prevention Center, China's Most Influential Cardiovascular Paper Award, 2007
- Peking University Teaching Excellence Award, 2007
- Ministry of Education 'Yangtze River Scholar' Distinguished Professor, 2006
- National Outstanding Young Scientist Fund, 2004
- Ministry of Education Young Teacher Award, 2003
- Katz Basic Science Research Prize, American Heart Association, 2002
- Comparative Physiology Scholander Award, American Physiological Society, 2001
- Richard J. Bing Young Investigator Award, International Society for Heart Research, 2001
- Zhang Xijun Fund National Young Outstanding Physiology Paper First Prize, Chinese Physiological Society, 1997
- Beijing Outstanding Teaching Achievement Award (Physiology and Experimental Teaching Group), 1997
- Peking University Teaching Excellence Award, 1991
- Peking University 'May Fourth' Science Award, 1988
