Professor | Yan Chuangye | Asia Growth Partners

Name	Yan Chuangye
Contact Information	yancy2019@mail.tsinghua.edu.cn
Language ability	Chinese, English
Province	Beijing

Name

Yan Chuangye

Contact Information

yancy2019@mail.tsinghua.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Tsinghua University
Faculty	Life Sciences
Academic Background & Achievements	2005-2009 Bachelor: Tsinghua University 2009-2015 PhD: Tsinghua University 2015-2019 Postdoctoral Researcher: Tsinghua University
Work Experience	2015-2019 - Tsinghua University - Postdoctoral Researcher 2019-present - Tsinghua University, School of Life Sciences - Assistant Professor, Associate Professor

University/Lab Affiliation and Title

Tsinghua University

Faculty

Life Sciences

Academic Background & Achievements

2005-2009 Bachelor: Tsinghua University
2009-2015 PhD: Tsinghua University
2015-2019 Postdoctoral Researcher: Tsinghua University

Work Experience

2015-2019 - Tsinghua University - Postdoctoral Researcher
2019-present - Tsinghua University, School of Life Sciences - Assistant Professor, Associate Professor

Areas of Focus	Development and application of X-ray crystallography and cryo-EM methods. Structural biology of significant membrane proteins and submicroscopic structures during cell division. Structure and function of spliceosomes in eukaryotic cells and mechanisms of precursor mRNA splicing.
Publications	Molecular Mechanisms of pre-mRNA Splicing through Structural Biology of the Spliceosome, Yan, C.; Wan, R.; Shi, Y., 2019 Structures of the human spliceosomes before and after release of the ligated exon, Zhang, X.; Zhan, X.; Yan, C.#; Zhang, W.; Lei, J.; Shi, Y., 2019 Structures of the human pre-catalytic spliceosome and its precursor spliceosome, Zhan, X.; Yan, C.#; Zhang, X.; Lei, J.; Shi, Y., 2018 Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activation, Bai, R.; Wan, R.; Yan, C.; Lei, J.; Shi, Y., 2018 Structure of the human activated spliceosome in three conformational states, Zhang, X.; Yan, C.#; Zhan, X.; Li, L.; Lei, J.; Shi, Y., 2018 Structure of a human catalytic step I spliceosome, Zhan, X.; Yan, C.#; Zhang, X.; Lei, J.; Shi, Y., 2018 An Atomic Structure of the Human Spliceosome, Zhang, X.; Yan, C.#; Hang, J.; Finci, L.I.; Lei, J.; Shi, Y., 2017 Structure of a yeast step II catalytically activated spliceosome, Yan, C.; Wan, R.; Bai, R.; Huang, G.; Shi, Y., 2017 Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiae, Wan, R.; Yan, C.; Bai, R.; Lei, J.; Shi, Y., 2017 Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae, Bai, R.; Yan, C.; Wan, R.; Lei, J.; Shi, Y., 2017 Structure of a yeast activated spliceosome at 3.5 A resolution, Yan, C.; Wan, R.; Bai, R.; Huang, G.; Shi, Y., 2016 The 3.8 A structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis, Wan, R.; Yan, C.; Bai, R.; Wang, L.; Huang, M.; Wong, C.C.; Shi, Y., 2016 Structure of a yeast catalytic step I spliceosome at 3.4 A resolution, Wan, R.; Yan, C.; Bai, R.; Huang, G.; Shi, Y., 2016 Structure of a yeast spliceosome at 3.6-angstrom resolution, Yan, C.; Hang, J.; Wan, R.; Huang, M.; Wong, C.C.; Shi, Y., 2015 Structural basis of pre-mRNA splicing, Hang, J.; Wan, R.; Yan, C.; Shi, Y., 2015 Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution, Yan, Z.; Bai, X.; Yan, C.; Wu, J.; Li, Z.; Xie, T.; Peng, W.; Yin, C.; Li, X.; Scheres, S.H.W.; et al., 2015 An atomic structure of human gamma-secretase, Bai, X.C.; Yan, C.; Yang, G.; Lu, P.; Ma, D.; Sun, L.; Zhou, R.; Scheres, S.H.W.; Shi, Y., 2015 Crystal structure of the gamma-secretase component nicastrin, Xie, T.; Yan, C.; Zhou, R.; Zhao, Y.; Sun, L.; Yang, G.; Lu, P.; Ma, D.; Shi, Y., 2014 Structural basis for sequence-specific recognition of DNA by TAL effectors, Deng D.; Yan C.; Pan X.*; Mahfouz M.; Wang J.; Zhu J.K.; Shi Y.; Yan N., 2012

Areas of Focus

Development and application of X-ray crystallography and cryo-EM methods.
Structural biology of significant membrane proteins and submicroscopic structures during cell division.
Structure and function of spliceosomes in eukaryotic cells and mechanisms of precursor mRNA splicing.

Publications

Molecular Mechanisms of pre-mRNA Splicing through Structural Biology of the Spliceosome, Yan, C.*; Wan, R.*; Shi, Y., 2019
Structures of the human spliceosomes before and after release of the ligated exon, Zhang, X.; Zhan, X.; Yan, C.*#; Zhang, W.; Lei, J.; Shi, Y., 2019
Structures of the human pre-catalytic spliceosome and its precursor spliceosome, Zhan, X.; Yan, C.*#; Zhang, X.; Lei, J.; Shi, Y., 2018
Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activation, Bai, R.*; Wan, R.; Yan, C.*; Lei, J.; Shi, Y., 2018
Structure of the human activated spliceosome in three conformational states, Zhang, X.*; Yan, C.*#; Zhan, X.; Li, L.; Lei, J.; Shi, Y., 2018
Structure of a human catalytic step I spliceosome, Zhan, X.*; Yan, C.*#; Zhang, X.; Lei, J.; Shi, Y., 2018
An Atomic Structure of the Human Spliceosome, Zhang, X.*; Yan, C.*#; Hang, J.; Finci, L.I.; Lei, J.; Shi, Y., 2017
Structure of a yeast step II catalytically activated spliceosome, Yan, C.*; Wan, R.; Bai, R.; Huang, G.; Shi, Y., 2017
Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiae, Wan, R.*; Yan, C.*; Bai, R.; Lei, J.; Shi, Y., 2017
Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae, Bai, R.*; Yan, C.*; Wan, R.; Lei, J.; Shi, Y., 2017
Structure of a yeast activated spliceosome at 3.5 A resolution, Yan, C.*; Wan, R.; Bai, R.; Huang, G.; Shi, Y., 2016
The 3.8 A structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis, Wan, R.*; Yan, C.*; Bai, R.; Wang, L.; Huang, M.; Wong, C.C.; Shi, Y., 2016
Structure of a yeast catalytic step I spliceosome at 3.4 A resolution, Wan, R.*; Yan, C.*; Bai, R.; Huang, G.*; Shi, Y., 2016
Structure of a yeast spliceosome at 3.6-angstrom resolution, Yan, C.*; Hang, J.; Wan, R.; Huang, M.; Wong, C.C.; Shi, Y., 2015
Structural basis of pre-mRNA splicing, Hang, J.*; Wan, R.; Yan, C.*; Shi, Y., 2015
Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution, Yan, Z.*; Bai, X.; Yan, C.*; Wu, J.; Li, Z.; Xie, T.; Peng, W.; Yin, C.; Li, X.; Scheres, S.H.W.; et al., 2015
An atomic structure of human gamma-secretase, Bai, X.C.*; Yan, C.*; Yang, G.; Lu, P.; Ma, D.; Sun, L.; Zhou, R.; Scheres, S.H.W.; Shi, Y., 2015
Crystal structure of the gamma-secretase component nicastrin, Xie, T.*; Yan, C.*; Zhou, R.; Zhao, Y.; Sun, L.; Yang, G.; Lu, P.; Ma, D.; Shi, Y., 2014
Structural basis for sequence-specific recognition of DNA by TAL effectors, Deng D.*; Yan C.*; Pan X.*; Mahfouz M.; Wang J.; Zhu J.K.; Shi Y.; Yan N., 2012

X-Ray Crystallography Cryo-Em Method Development Membrane Proteins Cell Division Submicroscopic Structures Spliceosome Eukaryotic Cells Mrna Splicing Structural Biology

Yan Chuangye - Tsinghua University

Qiangfeng Cliff Zhang - Tsinghua University

Mao-Fu Liao - Southern University of Science and Technology

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