Professor | 闫创业 | 数字化转型顾问

Name	闫创业
Contact Information	yancy2019@mail.tsinghua.edu.cn
Language ability	中文, 英语
Province	北京

Name

闫创业

Contact Information

yancy2019@mail.tsinghua.edu.cn

Language ability

中文, 英语

Province

北京

University/Lab Affiliation and Title	清华大学
Faculty	Life Sciences
Academic Background & Achievements	2005-2009 学士：清华大学 2009-2015 博士：清华大学 2015-2019 博士后：清华大学
Work Experience	2015-2019 - 清华大学 - 博士后 2019-至今 - 清华大学生命科学学院 - 助理教授、副教授

University/Lab Affiliation and Title

清华大学

Faculty

Life Sciences

Academic Background & Achievements

2005-2009 学士：清华大学
2009-2015 博士：清华大学
2015-2019 博士后：清华大学

Work Experience

2015-2019 - 清华大学 - 博士后
2019-至今 - 清华大学生命科学学院 - 助理教授、副教授

Areas of Focus	X-射线晶体学以及冷冻电镜方法的开发及应用。重要膜蛋白的结构生物学研究以及细胞分裂过程中亚显微结构的研究。真核细胞中剪接体的结构和功能以及前体信使RNA剪接机制的研究。
Publications	Molecular Mechanisms of pre-mRNA Splicing through Structural Biology of the Spliceosome, Yan, C.; Wan, R.; Shi, Y., 2019 Structures of the human spliceosomes before and after release of the ligated exon, Zhang, X.; Zhan, X.; Yan, C.#; Zhang, W.; Lei, J.; Shi, Y., 2019 Structures of the human pre-catalytic spliceosome and its precursor spliceosome, Zhan, X.; Yan, C.#; Zhang, X.; Lei, J.; Shi, Y., 2018 Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activation, Bai, R.; Wan, R.; Yan, C.; Lei, J.; Shi, Y., 2018 Structure of the human activated spliceosome in three conformational states, Zhang, X.; Yan, C.#; Zhan, X.; Li, L.; Lei, J.; Shi, Y., 2018 Structure of a human catalytic step I spliceosome, Zhan, X.; Yan, C.#; Zhang, X.; Lei, J.; Shi, Y., 2018 An Atomic Structure of the Human Spliceosome, Zhang, X.; Yan, C.#; Hang, J.; Finci, L.I.; Lei, J.; Shi, Y., 2017 Structure of a yeast step II catalytically activated spliceosome, Yan, C.; Wan, R.; Bai, R.; Huang, G.; Shi, Y., 2017 Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiae, Wan, R.; Yan, C.; Bai, R.; Lei, J.; Shi, Y., 2017 Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae, Bai, R.; Yan, C.; Wan, R.; Lei, J.; Shi, Y., 2017 Structure of a yeast activated spliceosome at 3.5 A resolution, Yan, C.; Wan, R.; Bai, R.; Huang, G.; Shi, Y., 2016 The 3.8 A structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis, Wan, R.; Yan, C.; Bai, R.; Wang, L.; Huang, M.; Wong, C.C.; Shi, Y., 2016 Structure of a yeast catalytic step I spliceosome at 3.4 A resolution, Wan, R.; Yan, C.; Bai, R.; Huang, G.; Shi, Y., 2016 Structure of a yeast spliceosome at 3.6-angstrom resolution, Yan, C.; Hang, J.; Wan, R.; Huang, M.; Wong, C.C.; Shi, Y., 2015 Structural basis of pre-mRNA splicing, Hang, J.; Wan, R.; Yan, C.; Shi, Y., 2015 Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution, Yan, Z.; Bai, X.; Yan, C.; Wu, J.; Li, Z.; Xie, T.; Peng, W.; Yin, C.; Li, X.; Scheres, S.H.W.; et al., 2015 An atomic structure of human gamma-secretase, Bai, X.C.; Yan, C.; Yang, G.; Lu, P.; Ma, D.; Sun, L.; Zhou, R.; Scheres, S.H.W.; Shi, Y., 2015 Crystal structure of the gamma-secretase component nicastrin, Xie, T.; Yan, C.; Zhou, R.; Zhao, Y.; Sun, L.; Yang, G.; Lu, P.; Ma, D.; Shi, Y., 2014 Structural basis for sequence-specific recognition of DNA by TAL effectors, Deng D.; Yan C.; Pan X.*; Mahfouz M.; Wang J.; Zhu J.K.; Shi Y.; Yan N., 2012

Areas of Focus

X-射线晶体学以及冷冻电镜方法的开发及应用。
重要膜蛋白的结构生物学研究以及细胞分裂过程中亚显微结构的研究。
真核细胞中剪接体的结构和功能以及前体信使RNA剪接机制的研究。

Publications

Molecular Mechanisms of pre-mRNA Splicing through Structural Biology of the Spliceosome, Yan, C.*; Wan, R.*; Shi, Y., 2019
Structures of the human spliceosomes before and after release of the ligated exon, Zhang, X.; Zhan, X.; Yan, C.*#; Zhang, W.; Lei, J.; Shi, Y., 2019
Structures of the human pre-catalytic spliceosome and its precursor spliceosome, Zhan, X.; Yan, C.*#; Zhang, X.; Lei, J.; Shi, Y., 2018
Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activation, Bai, R.*; Wan, R.; Yan, C.*; Lei, J.; Shi, Y., 2018
Structure of the human activated spliceosome in three conformational states, Zhang, X.*; Yan, C.*#; Zhan, X.; Li, L.; Lei, J.; Shi, Y., 2018
Structure of a human catalytic step I spliceosome, Zhan, X.*; Yan, C.*#; Zhang, X.; Lei, J.; Shi, Y., 2018
An Atomic Structure of the Human Spliceosome, Zhang, X.*; Yan, C.*#; Hang, J.; Finci, L.I.; Lei, J.; Shi, Y., 2017
Structure of a yeast step II catalytically activated spliceosome, Yan, C.*; Wan, R.; Bai, R.; Huang, G.; Shi, Y., 2017
Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiae, Wan, R.*; Yan, C.*; Bai, R.; Lei, J.; Shi, Y., 2017
Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae, Bai, R.*; Yan, C.*; Wan, R.; Lei, J.; Shi, Y., 2017
Structure of a yeast activated spliceosome at 3.5 A resolution, Yan, C.*; Wan, R.; Bai, R.; Huang, G.; Shi, Y., 2016
The 3.8 A structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis, Wan, R.*; Yan, C.*; Bai, R.; Wang, L.; Huang, M.; Wong, C.C.; Shi, Y., 2016
Structure of a yeast catalytic step I spliceosome at 3.4 A resolution, Wan, R.*; Yan, C.*; Bai, R.; Huang, G.*; Shi, Y., 2016
Structure of a yeast spliceosome at 3.6-angstrom resolution, Yan, C.*; Hang, J.; Wan, R.; Huang, M.; Wong, C.C.; Shi, Y., 2015
Structural basis of pre-mRNA splicing, Hang, J.*; Wan, R.; Yan, C.*; Shi, Y., 2015
Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution, Yan, Z.*; Bai, X.; Yan, C.*; Wu, J.; Li, Z.; Xie, T.; Peng, W.; Yin, C.; Li, X.; Scheres, S.H.W.; et al., 2015
An atomic structure of human gamma-secretase, Bai, X.C.*; Yan, C.*; Yang, G.; Lu, P.; Ma, D.; Sun, L.; Zhou, R.; Scheres, S.H.W.; Shi, Y., 2015
Crystal structure of the gamma-secretase component nicastrin, Xie, T.*; Yan, C.*; Zhou, R.; Zhao, Y.; Sun, L.; Yang, G.; Lu, P.; Ma, D.; Shi, Y., 2014
Structural basis for sequence-specific recognition of DNA by TAL effectors, Deng D.*; Yan C.*; Pan X.*; Mahfouz M.; Wang J.; Zhu J.K.; Shi Y.; Yan N., 2012

X射线晶体学冷冻电镜方法开发膜蛋白细胞分裂亚显微结构剪接体真核细胞 Mrna剪接结构生物学

闫创业 - 清华大学

宋高洁 - 华东师范大学

王佳伟 - 清华大学

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