Professor | Bo Zhang | Asia Growth Partners

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Name	Bo Zhang
Contact Information	{'en': 'Email: bzhang (AT) pku.edu.cn, Office Phone: 62759072, Lab Phone: 62753077', 'zh': '电子邮件：bzhang (AT) pku.edu.cn, 办公室电话：62759072, 实验室电话：62753077', 'de': 'E-Mail: bzhang (AT) pku.edu.cn, Bürotelefon: 62759072, Labortelefon: 62753077'}
Language ability	Chinese, English
Province	Beijing

Upload Avatar (500 x 500)

Name

Bo Zhang

Contact Information

{'en': 'Email: bzhang (AT) pku.edu.cn, Office Phone: 62759072, Lab Phone: 62753077', 'zh': '电子邮件：bzhang (AT) pku.edu.cn, 办公室电话：62759072, 实验室电话：62753077', 'de': 'E-Mail: bzhang (AT) pku.edu.cn, Bürotelefon: 62759072, Labortelefon: 62753077'}

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Life Sciences
Academic Background & Achievements	1992 - 1995: PhD in Cell Biology, Peking University 1989 - 1992: Master's in Cell Biology, Peking University 1985 - 1989: Bachelor's in Cell Biology, Peking University
Work Experience	2004 - Present: Professor, Peking University 2004 - 2005: Visiting Scholar, UCLA, Department of Molecular, Cell & Developmental Biology 1997 - 2002: Postdoctoral Fellow, University of Zurich, Institute of Molecular Biology 1995 - 2004: Associate Professor, Peking University 1994 - 1995: Visiting Scholar, University of Wisconsin-Madison, Department of Biomolecular Chemistry
Awards	Yang Fuqing Wang Yangyuan Outstanding Teaching and Research Award, 2018 Peking University Outstanding Teaching Award, 2013 Peking University Outstanding Teaching Award, 2009 Peking University Dongbao Teaching Award, 2007 Ministry of Education 'New Century Excellent Talents Support Plan', 2004 First Prize in Peking University Young Teachers Teaching Skills and Modern Education Technology Application Demonstration Competition, 2004 Second Prize of National Natural Science Award, 2001 First Prize of Chinese Universities Science and Technology Award, 2001

University/Lab Affiliation and Title

Peking University

Faculty

Life Sciences

Academic Background & Achievements

1992 - 1995: PhD in Cell Biology, Peking University
1989 - 1992: Master's in Cell Biology, Peking University
1985 - 1989: Bachelor's in Cell Biology, Peking University

Work Experience

2004 - Present: Professor, Peking University
2004 - 2005: Visiting Scholar, UCLA, Department of Molecular, Cell & Developmental Biology
1997 - 2002: Postdoctoral Fellow, University of Zurich, Institute of Molecular Biology
1995 - 2004: Associate Professor, Peking University
1994 - 1995: Visiting Scholar, University of Wisconsin-Madison, Department of Biomolecular Chemistry

Awards

Yang Fuqing Wang Yangyuan Outstanding Teaching and Research Award, 2018
Peking University Outstanding Teaching Award, 2013
Peking University Outstanding Teaching Award, 2009
Peking University Dongbao Teaching Award, 2007
Ministry of Education 'New Century Excellent Talents Support Plan', 2004
First Prize in Peking University Young Teachers Teaching Skills and Modern Education Technology Application Demonstration Competition, 2004
Second Prize of National Natural Science Award, 2001
First Prize of Chinese Universities Science and Technology Award, 2001

Areas of Focus	Vertebrate embryonic development and organ regeneration using zebrafish as a model organism Development and improvement of functional genomics research techniques, especially CRISPR/Cas-based genome editing technologies
Publications	Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration, Wu, Z., Shi, Y., Cui, Y., Xing, X., Zhang, L., Liu, D., Zhang, Y., Dong, J., Jin, L., Pang, M., Xiao, R.-P., Zhu, Z., Xiong, J.-W., Tong, X., Zhang, Y., Wang, S., Tang, F. and Zhang, B., 2022 ErCas12a and T5exo-ErCas12a mediate simple and efficient genome editing in zebrafish, Han, B., Zhang, Y., Zhou, Y., Zhang, B., Krueger, C. J., Bi, X., Zhu, Z., Tong, X. and Zhang, B., 2022 Bi-FoRe: An efficient bidirectional knockin strategy to generate pairwise conditional alleles with fluorescent indicators, Han, B., Zhang, Y., Bi, X., Zhou, Y., Krueger, C. J., Hu, X., Zhu, Z., Tong, X. and Zhang, B., 2021 A mutation in VWA1, encoding von Willebrand factor A domain-containing protein 1, is associated with hemifacial microsomia, Wang, Y., Ping, L., Luan, X., Chen, Y., Fan, X., Li, L., Liu, Y., Wang, P., Zhang, S., Zhang, B. and Chen, X., 2020 One-step efficient generation of dual-function conditional knockout and geno-tagging alleles in zebrafish, Li, W., Zhang, Y., Han, B., Li, L., Li, M., Lu, X., Chen, C., Lu, M., Zhang, Y., Jia, X., Zhu, Z., Tong, X. and Zhang, B., 2019 Single-cell analyses identify distinct and intermediate states of zebrafish pancreatic islet development, Lu, C.-J., Fan, X.-Y., Guo, Y.-F., Cheng, Z.-C., Dong, J., Chen, J.-Z., Li, L.-Y., Wang, M.-W., Wu, Z.-K., Wang, F., Tong, X.-J., Luo, L.-F., Tang, F.-C., Zhu Z.-Y. and Zhang, B., 2018 A mutation in ADIPOR1 causes nonsyndromic autosomal dominant retinitis pigmentosa, Zhang, J., Wang, C., Shen, Y., Chen, N., Wang, L., Liang, L., Guo, T., Yin, X., Ma, Z., Zhang, B. and Yang, L., 2016 Generation of targeted genomic deletions through CRISPR/Cas system in zebrafish, Xiao, A. and Zhang, B., 2016 Targeted Mutagenesis in Zebrafish by TALENs, Huang, P., Xiao, A., Tong, X., Lin, S. and Zhang, B., 2016 Efficient gene targeting in zebrafish mediated by a zebrafish-codon-optimized Cas9 and evaluation of off-targeting effect, Liu, D., Wang, Z., Xiao, A., Zhang, Y., Li, W., Zu, Y., Yao, S., Lin, S. and Zhang, B., 2014 CasOT: a genome-wide Cas9/gRNA off-target searching tool, Xiao, A., Cheng, Z., Kong, L., Zhu, Z., Lin, S., Gao G. and Zhang, B., 2014 TALEN construction via Unit Assembly method and targeted genome modifications in zebrafish, Huang, P., Xiao, A., Tong, X., Zu, Y., Wang, Z. and Zhang, B., 2014 Kctd10 regulates heart morphogenesis by repressing the transcriptional activity of Tbx5a in zebrafish, Tong, X., Zu, Y., Li, Z., Li, W., Ying, L., Yang, J., Wang, X., He, S., Liu, D., Zhu, Z., Chen, J., Lin, S. and Zhang, B., 2014 TALEN-mediated precise genome modification by homologous recombination in zebrafish, Zu, Y., Tong, X., Wang, Z., Liu, D., Pan, R., Li, Z., Hu, Y., Luo, Z., Huang, P., Wu, Q., Zhu, Z., Zhang, B., Lin, S., 2013, 2013 EENdb: a database and knowledge base of ZFNs and TALENs for endonuclease engineering, Xiao, A., Wu, Y., Yang, Z., Hu, Y., Wang, W., Zhang, Y., Kong, L., Gao, G., Zhu, Z., Lin, S. and Zhang, B., 2013 Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish, Xiao, A., Wang, Z., Hu, Y., Wu, Y., Luo, Z., Yang, Z., Zu, Y., Li, W., Huang, P., Tong, X., Zhu, Z., Lin, S. and Zhang, B., 2013 TALEN or Cas9 - rapid, efficient and specific choices for genome modifications, Wei, C., Liu, J., Yu, Z., Zhang, B., Gao, G. and Jiao, R., 2013 Eif3ba regulates cranial neural crest development by modulating p53 in zebrafish, Xia, Z., Tong, X., Liang, F., Zhang, Y., Kuok, C., Zhang, Y., Liu, X., Zhu, Z., Lin, S. and Zhang, B., 2013 Ngs (notochord granular surface) encodes a novel type of intermediate filament family protein essential for notochord maintenance in zebrafish, Tong, X., Xia, Z., Zu, Y., Telfer H., Hu, J., Yu, J., Liu, H., Zhang, Q., Sodmergen, Lin, S. and Zhang, B., 2013 Sperm DNA methylome is inherited during zebrafish early embryogenesis, Jiang, L., Zhang, J., Wang, J.-J., Wang, L., Zhang, L., Li, G., Yang, X., Ma, X., Sun, X., Cai, J., Zhang, J., Huang, X., Yu,. M., Wang, X., Liu, F., Wu, C.-I, He, C., Zhang, B., Ci, W. and Liu, J., 2013 Reverse genetic approaches in zebrafish, Huang, P., Zhu, Z., Lin, S. and Zhang, B., 2012 Genomic deletion induced by Tol2 transposon excision in zebrafish, Huang, P., Xu, L., Liang, W., Tam, C. I., Zhang, Y., Qi, F., Zhu, Z., Lin, S. and Zhang, B., 2012

Areas of Focus

Vertebrate embryonic development and organ regeneration using zebrafish as a model organism
Development and improvement of functional genomics research techniques, especially CRISPR/Cas-based genome editing technologies

Publications

Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration, Wu, Z., Shi, Y., Cui, Y., Xing, X., Zhang, L., Liu, D., Zhang, Y., Dong, J., Jin, L., Pang, M., Xiao, R.-P., Zhu, Z., Xiong, J.-W., Tong, X., Zhang, Y., Wang, S., Tang, F. and Zhang, B., 2022
ErCas12a and T5exo-ErCas12a mediate simple and efficient genome editing in zebrafish, Han, B., Zhang, Y., Zhou, Y., Zhang, B., Krueger, C. J., Bi, X., Zhu, Z., Tong, X. and Zhang, B., 2022
Bi-FoRe: An efficient bidirectional knockin strategy to generate pairwise conditional alleles with fluorescent indicators, Han, B., Zhang, Y., Bi, X., Zhou, Y., Krueger, C. J., Hu, X., Zhu, Z., Tong, X. and Zhang, B., 2021
A mutation in VWA1, encoding von Willebrand factor A domain-containing protein 1, is associated with hemifacial microsomia, Wang, Y., Ping, L., Luan, X., Chen, Y., Fan, X., Li, L., Liu, Y., Wang, P., Zhang, S., Zhang, B. and Chen, X., 2020
One-step efficient generation of dual-function conditional knockout and geno-tagging alleles in zebrafish, Li, W., Zhang, Y., Han, B., Li, L., Li, M., Lu, X., Chen, C., Lu, M., Zhang, Y., Jia, X., Zhu, Z., Tong, X. and Zhang, B., 2019
Single-cell analyses identify distinct and intermediate states of zebrafish pancreatic islet development, Lu, C.-J., Fan, X.-Y., Guo, Y.-F., Cheng, Z.-C., Dong, J., Chen, J.-Z., Li, L.-Y., Wang, M.-W., Wu, Z.-K., Wang, F., Tong, X.-J., Luo, L.-F., Tang, F.-C., Zhu Z.-Y. and Zhang, B., 2018
A mutation in ADIPOR1 causes nonsyndromic autosomal dominant retinitis pigmentosa, Zhang, J., Wang, C., Shen, Y., Chen, N., Wang, L., Liang, L., Guo, T., Yin, X., Ma, Z., Zhang, B. and Yang, L., 2016
Generation of targeted genomic deletions through CRISPR/Cas system in zebrafish, Xiao, A. and Zhang, B., 2016
Targeted Mutagenesis in Zebrafish by TALENs, Huang, P., Xiao, A., Tong, X., Lin, S. and Zhang, B., 2016
Efficient gene targeting in zebrafish mediated by a zebrafish-codon-optimized Cas9 and evaluation of off-targeting effect, Liu, D., Wang, Z., Xiao, A., Zhang, Y., Li, W., Zu, Y., Yao, S., Lin, S. and Zhang, B., 2014
CasOT: a genome-wide Cas9/gRNA off-target searching tool, Xiao, A., Cheng, Z., Kong, L., Zhu, Z., Lin, S., Gao G. and Zhang, B., 2014
TALEN construction via Unit Assembly method and targeted genome modifications in zebrafish, Huang, P., Xiao, A., Tong, X., Zu, Y., Wang, Z. and Zhang, B., 2014
Kctd10 regulates heart morphogenesis by repressing the transcriptional activity of Tbx5a in zebrafish, Tong, X., Zu, Y., Li, Z., Li, W., Ying, L., Yang, J., Wang, X., He, S., Liu, D., Zhu, Z., Chen, J., Lin, S. and Zhang, B., 2014
TALEN-mediated precise genome modification by homologous recombination in zebrafish, Zu, Y., Tong, X., Wang, Z., Liu, D., Pan, R., Li, Z., Hu, Y., Luo, Z., Huang, P., Wu, Q., Zhu, Z., Zhang, B., Lin, S., 2013, 2013
EENdb: a database and knowledge base of ZFNs and TALENs for endonuclease engineering, Xiao, A., Wu, Y., Yang, Z., Hu, Y., Wang, W., Zhang, Y., Kong, L., Gao, G., Zhu, Z., Lin, S. and Zhang, B., 2013
Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish, Xiao, A., Wang, Z., Hu, Y., Wu, Y., Luo, Z., Yang, Z., Zu, Y., Li, W., Huang, P., Tong, X., Zhu, Z., Lin, S. and Zhang, B., 2013
TALEN or Cas9 - rapid, efficient and specific choices for genome modifications, Wei, C., Liu, J., Yu, Z., Zhang, B., Gao, G. and Jiao, R., 2013
Eif3ba regulates cranial neural crest development by modulating p53 in zebrafish, Xia, Z., Tong, X., Liang, F., Zhang, Y., Kuok, C., Zhang, Y., Liu, X., Zhu, Z., Lin, S. and Zhang, B., 2013
Ngs (notochord granular surface) encodes a novel type of intermediate filament family protein essential for notochord maintenance in zebrafish, Tong, X., Xia, Z., Zu, Y., Telfer H., Hu, J., Yu, J., Liu, H., Zhang, Q., Sodmergen, Lin, S. and Zhang, B., 2013
Sperm DNA methylome is inherited during zebrafish early embryogenesis, Jiang, L., Zhang, J., Wang, J.-J., Wang, L., Zhang, L., Li, G., Yang, X., Ma, X., Sun, X., Cai, J., Zhang, J., Huang, X., Yu,. M., Wang, X., Liu, F., Wu, C.-I, He, C., Zhang, B., Ci, W. and Liu, J., 2013
Reverse genetic approaches in zebrafish, Huang, P., Zhu, Z., Lin, S. and Zhang, B., 2012
Genomic deletion induced by Tol2 transposon excision in zebrafish, Huang, P., Xu, L., Liang, W., Tam, C. I., Zhang, Y., Qi, F., Zhu, Z., Lin, S. and Zhang, B., 2012

Zebrafish Embryonic Development Organ Regeneration Vertebrates Crispr/Cas Genome Editing Functional Genomics Gene Expression Pancreatic Development Cardiovascular Research

Xiangjun Tong - Peking University

Shao Rong Gao - Tongji University

Jiang Cizhong - Tongji University

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