Professor | Xiaofeng Zheng | Asia Growth Partners

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Name	Xiaofeng Zheng
Contact Information	{'en': 'xiaofengz (AT) pku.edu.cn', 'zh': 'xiaofengz (AT) pku.edu.cn', 'de': 'xiaofengz (AT) pku.edu.cn'}
Language ability	Chinese, English
Province	Beijing

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Name

Xiaofeng Zheng

Contact Information

{'en': 'xiaofengz (AT) pku.edu.cn', 'zh': 'xiaofengz (AT) pku.edu.cn', 'de': 'xiaofengz (AT) pku.edu.cn'}

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Life Sciences
Academic Background & Achievements	Ph.D. in Biochemistry and Molecular Biology, Tokyo University of Agriculture and Technology Postdoctoral Research Fellow, Pennsylvania State University Vice Director of the National Key Laboratory of Protein and Gene Research
Work Experience	2008 June - Present, Professor, Peking University, School of Life Sciences 2002 May - 2008 May, Associate Professor, Peking University, School of Life Sciences 1998 April - 2002 April, Postdoctoral Research Fellow, University of Pennsylvania
Awards	Bayer Scholar Award, 2020 Outstanding Doctoral Dissertation Advisor, Peking University, 2020 Outstanding Teaching Award, Peking University, 2017 Outstanding Class Advisor, Peking University, 2016 Outstanding Doctoral Dissertation Advisor, Peking University, 2016 Outstanding Doctoral Dissertation Advisor, Peking University, 2014 Dongbao Teacher Award, Peking University, 2013 Dongbao Teacher Award, Peking University, 2009 Outstanding Young Teacher Basic Skills Award, Peking University, 2007 Dongbao Teacher Award, Peking University, 2006 Outstanding Counselor, Beijing, 2006 Tan Jiazhen Fund Life Science Mentor Award, 2006 Outstanding Class Advisor, Peking University, 2005

University/Lab Affiliation and Title

Peking University

Faculty

Life Sciences

Academic Background & Achievements

Ph.D. in Biochemistry and Molecular Biology, Tokyo University of Agriculture and Technology
Postdoctoral Research Fellow, Pennsylvania State University
Vice Director of the National Key Laboratory of Protein and Gene Research

Work Experience

2008 June - Present, Professor, Peking University, School of Life Sciences
2002 May - 2008 May, Associate Professor, Peking University, School of Life Sciences
1998 April - 2002 April, Postdoctoral Research Fellow, University of Pennsylvania

Awards

Bayer Scholar Award, 2020
Outstanding Doctoral Dissertation Advisor, Peking University, 2020
Outstanding Teaching Award, Peking University, 2017
Outstanding Class Advisor, Peking University, 2016
Outstanding Doctoral Dissertation Advisor, Peking University, 2016
Outstanding Doctoral Dissertation Advisor, Peking University, 2014
Dongbao Teacher Award, Peking University, 2013
Dongbao Teacher Award, Peking University, 2009
Outstanding Young Teacher Basic Skills Award, Peking University, 2007
Dongbao Teacher Award, Peking University, 2006
Outstanding Counselor, Beijing, 2006
Tan Jiazhen Fund Life Science Mentor Award, 2006
Outstanding Class Advisor, Peking University, 2005

Areas of Focus	Identification and molecular mechanisms of proteins regulating tumor development and metastasis DNA damage repair—Genomic stability—Cancer Virus—Innate immunity—DNA damage response—Inflammation and cancer
Publications	ATM-ESCO2-SMC3 axis promotes 53BP1 recruitment in response to DNA damage and safeguards genome integrity by stabilizing cohesin complex, Fu JF, Zhou SR, Xu HL, Liao LM, Shen H, Du P, Zheng XF, 2023 Metabolic Interventions Combined with CTLA-4 and PD-1/PD-L1 Blockade for the Treatment of Tumors: Mechanisms and Strategies, Liao LM, Xu HL, Zhao YH, Zheng XF, 2023 SENP1 decreases RNF168 phase separation to promote DNA damage repair and drug resistance in colon cancer, Wei M, Huang XP, Liao LM, Tian YL, Zheng XF, 2023 hCINAP alleviates senescence through regulating MDM2 status via multiple mechanisms, Huang XP, Zhao Y, Wei M, Zhuge RP, Zheng XF, 2023 hCINAP controls lineage differentiation of embryonic stem cells by regulating NEDD4 liquid-liquid phase separation-mediated YAP1 activation, Zhuge RP, Wang C, Wang J, Yu SY, Liao LM, Zheng XF, 2023 PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As2O3 by stabilizing oncoprotein PML-RARα, Huang XP, Yang YF, Zhu D, Zhao Y, Wei M, Li K, Zu HH, Zheng XF, 2022 Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy, Zhao Y, Huang XP, Zhu D, Wei M, Yu SY, Tian YL, Zheng XF, 2022 Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis, Yu SY, Zang WC, Oiu YC, Liao LM, Zheng XF, 2022 Unique structural features of the adenylate kinase hCINAP/AK6 and its multifaceted functions in carcinogenesis and tumor progression, Xu RD, Yang YF, Zheng XF, 2021 Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1, Zhu D, Xu R, Huang X, Tang Z, Tian Y, Zhang J, Zheng XF, 2021

Areas of Focus

Identification and molecular mechanisms of proteins regulating tumor development and metastasis
DNA damage repair—Genomic stability—Cancer
Virus—Innate immunity—DNA damage response—Inflammation and cancer

Publications

ATM-ESCO2-SMC3 axis promotes 53BP1 recruitment in response to DNA damage and safeguards genome integrity by stabilizing cohesin complex, Fu JF, Zhou SR, Xu HL, Liao LM, Shen H, Du P, Zheng XF, 2023
Metabolic Interventions Combined with CTLA-4 and PD-1/PD-L1 Blockade for the Treatment of Tumors: Mechanisms and Strategies, Liao LM, Xu HL, Zhao YH, Zheng XF, 2023
SENP1 decreases RNF168 phase separation to promote DNA damage repair and drug resistance in colon cancer, Wei M, Huang XP, Liao LM, Tian YL, Zheng XF, 2023
hCINAP alleviates senescence through regulating MDM2 status via multiple mechanisms, Huang XP, Zhao Y, Wei M, Zhuge RP, Zheng XF, 2023
hCINAP controls lineage differentiation of embryonic stem cells by regulating NEDD4 liquid-liquid phase separation-mediated YAP1 activation, Zhuge RP, Wang C, Wang J, Yu SY, Liao LM, Zheng XF, 2023
PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As2O3 by stabilizing oncoprotein PML-RARα, Huang XP, Yang YF, Zhu D, Zhao Y, Wei M, Li K, Zu HH, Zheng XF, 2022
Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy, Zhao Y, Huang XP, Zhu D, Wei M, Yu SY, Tian YL, Zheng XF, 2022
Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis, Yu SY, Zang WC, Oiu YC, Liao LM, Zheng XF, 2022
Unique structural features of the adenylate kinase hCINAP/AK6 and its multifaceted functions in carcinogenesis and tumor progression, Xu RD, Yang YF, Zheng XF, 2021
Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1, Zhu D, Xu R, Huang X, Tang Z, Tian Y, Zhang J, Zheng XF, 2021

Tumor Metastasis Proteins Molecular Mechanisms Dna Damage Repair Genomic Stability Virus Innate Immunity Inflammation

Li Baojie - Shanghai Jiao Tong University

Zhang Feng - Shanghai Normal University

Xu Dongyi - Peking University

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