Upload Avatar (500 x 500)
Yujun Hou
Life Science
Tongji University
Shanghai
Language: Chinese, English
Cell Signaling
Neurodegenerative Diseases
Mitophagy
Alzheimer'S Disease
Nad+
Neuroinflammation
Genetics
Epigenetics
Aging
Natural Active Drugs
Areas of Focus
- Cell signaling and mechanisms of neurodegenerative diseases
- Mitophagy defects in Alzheimer's disease
- NAD+ and microglial neuroinflammation in Alzheimer's disease
- Genetic and epigenetic decoding of aging and age-related diseases
- Discovery and mechanism of natural active drugs for aging and Alzheimer's disease treatment
Work Experience
- 2015-2021 - National Institutes of Health (NIH), National Institute on Aging (NIA), Postdoctoral Researcher
- 2021-2022 - Tongji University, Distinguished Researcher
- 2022-Present - Tongji University, Professor
- 2021-Present - Tongji University Affiliated Oriental Hospital, Researcher
Academic Background & Achievements
- 2008 - Bachelor of Science: East China Normal University
- 2015 - Doctor of Science: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
- Awards: Butler-Williams Scholar, Nathan Shock Award
Publications
- NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING, Yujun Hou et al., 2021
- Mitophagy inhibits amyloid-beta and tau pathology and reverses cognitive deficits in models of Alzheimer's disease, Evandro F. Fang et al., 2019
- NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency, Yujun Hou et al., 2018
- Urolithin A improves Alzheimer’s disease cognition and restores mitophagy and lysosomal functions, Yujun Hou et al., 2024
- Ageing as a risk factor for neurodegenerative disease, Yujun Hou et al., 2019
- NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome, Evandro F. Fang et al., 2019
- RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice, Yujun Hou et al., 2023
- Alzheimer’s Amyloid-β Accelerates Cell Senescence and Suppresses SIRT1 in Human Neural Stem Cells, Rongyao Li et al., 2024
- Epigenetic marks or not? The discovery of novel DNA modifications in eukaryotes, Wei-Ying Meng et al., 2024
- Roles of NAD+ in Health and Aging, Sofie Lautrup et al., 2024
- Nicotinamide adenine dinucleotide supplementation drives gut microbiota variation in Alzheimer’s mouse model, Xixia Chu et al., 2022
- Genome instability in Alzheimer disease, Yujun Hou et al., 2017
Awards
- Butler-Williams Scholar
- Nathan Shock Award
