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Le Rongrong
Life Science
Tongji University
Shanghai
Language: Chinese, English
Somatic Cell Reprogramming
Stem Cell Aging
Molecular Mechanisms
Telomere Regulation
Embryonic Cell Reprogramming
Adult Stem Cell
Cellular Aging
Telomere Maintenance
Pluripotency
Cellular Reprogramming
Areas of Focus
- Molecular mechanisms of somatic cell reprogramming and stem cell aging
- Telomere regulation mechanisms in embryonic and somatic cell reprogramming
- Molecular mechanisms of adult stem cell aging
Work Experience
- 2021.12-present: Tongji University, School of Life Sciences and Technology, Professor
- 2014.10-2021.12: Tongji University, School of Life Sciences and Technology, Assistant Professor
Academic Background & Achievements
- 2008-2014: PhD in Life Sciences, China Agricultural University, Beijing Institute of Life Sciences
- Recipient of the National Natural Science Foundation of China Excellent Young Scientist Fund (2021)
- Recipient of the Shanghai Science and Technology Committee Young Scientist Star (A Category) (2021)
- Recipient of the Shanghai Morning Light Plan (2015)
Publications
- Dcaf11 activates Zscan4-mediated alternative telomere lengthening in early embryos and embryonic stem cells, Le Rongrong, 2020
- Enhanced telomere rejuvenation in pluripotent cells reprogrammed via nuclear transfer relative to induced pluripotent stem cells, Le Rongrong, 2014
- Unique Patterns of H3K4me3 and H3K27me3 in 2-Cell-like Embryonic Stem Cells, Le Rongrong, 2021
- Lessons from expanded potential of embryonic stem cells: Moving toward totipotency, Le Rongrong, 2020
- Oocyte-Specific Homeobox 1, Obox1, Facilitates Reprogramming by Promoting Mesenchymal-to-Epithelial Transition and Mitigating Cell Hyperproliferation, Le Rongrong, 2017
- Enhanced Rejuvenation in Induced Pluripotent Stem Cell Derived Neurons Compared with Directly Converted Neurons from an Aged Mouse, Le Rongrong, 2015
- High throughput sequencing identifies an imprinted gene, Grb10, associated with the pluripotency state in nuclear transfer embryonic stem cells, Le Rongrong, 2017
- Pkm2 can enhance pluripotency in ESCs and promote somatic cell reprogramming to iPSCs, Le Rongrong, 2017
- DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development, Le Rongrong, 2018
- Reduced Self-Diploidization and Improved Survival of Semi-cloned Mice Produced from Androgenetic Haploid Embryonic Stem Cells through Overexpression of Dnmt3b, Le Rongrong, 2018
- Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development, Le Rongrong, 2018
Awards
- National Natural Science Foundation of China Excellent Young Scientist Fund (2021): Award for outstanding young scientists in natural sciences
- Shanghai Science and Technology Committee Young Scientist Star (A Category) (2021): Recognition for promising young scientists in technology fields
- Shanghai Morning Light Plan (2015): Support for talented researchers in early stages of their careers
