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Zhiyong Mao
Life Science
Tongji University
Shanghai
Language: English, Chinese
Aging
Disease
Dna Repair
Stem Cells
Genomic Stability
Tumor
Therapeutics
Translational Medicine
Cellular Senescence
Biomarkers
Areas of Focus
- Aging and related diseases
- Stem cell genomic stability
- Development of new methods for delaying aging and treating related diseases
Work Experience
- 2010-2012 - University of Rochester, Department of Biology: Postdoctoral Researcher
- Since 2012 - Tongji University: Head of Research Group
Academic Background & Achievements
- 2002 - Bachelor's Degree: Nanjing University, School of Life Sciences
- 2004 - Master's Degree: Nanjing University, School of Life Sciences
- 2010 - PhD: University of Rochester, USA
- National Outstanding Young Scientist Award
- Overseas High-level Young Talent
Publications
- cGAS-Ku80 complex regulates the choice of two nonhomologous end joining pathways, Zhang H, Jiang L, Du X, Qian Z, Wu G, Jiang Y, Mao Z, 2024
- SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner, Geng A, Sun J, Tang H, Yu Y, Wang X, Zhang J, Wang X, Sun X, Zhou X, Gao N, Tan R, Xu Z, Jiang Y, Mao Z, 2024
- Circadian factors CLOCK and BMAL1 promote nonhomologous end joining and antagonize cellular senescence, Chen Y, Xu X, Chen Z, Chen L, Jiang Y, Mao Z, 2024
- Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation, Zhen Z, Chen Y, Wang H, Tang H, Zhang H, Liu H, Jiang Y, Mao Z, 2023
- Androgen signaling stabilizes genomes to counteract senescence by promoting XRCC4 transcription, Chen Y, Zhen Z, Chen L, Wang H, Wang X, Sun X, Song Z, Wang H, Lin Y, Zhang W, Wu G, Jiang Y, Mao Z, 2023
- Impaired end joining induces cardiac atrophy in a Hutchinson–Gilford progeria mouse model, Chen Y, Huang S, Cui Z, Sun X, Tang Y, Zhang H, Chen Z, Jiang R, Zhang W, Li X, Chen J, Liu B, Jiang Y, Wei K, Mao Z, 2023
- Loss of ER/PR/HER2 promotes USP15-dependent stabilization of PARP1 in triple-negative breast cancer, Sun X, Tang H, Chen Y, Chen Z, Hu Z, Cui Z, Tao Y, Yuan J, Fu Y, Zhuang Z, He Q, Li Q, Xu X, Wan X, Jiang Y, Mao Z, 2023
- Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer, Zhang W, Wang M, Song Z, Fu Q, Chen J, Zhang W, Gao S, Sun X, Yang G, Zhang Q, Yang J, Tang H, Wang H, Kou X, Wang H, Mao Z, Xu X, Gao S, Jiang Y, 2023
- IDDoR: A novel reporter mouse system for simultaneous and quantitative in vivo analysis of both DNA double-strand break repair pathways, Chen Y, Cui Z, Chen Z, Jiang Y, Mao Z, 2022
- Enhancement of Xrcc1-mediated base excision repair improves the genetic stability and pluripotency of iPSCs, Zhao K, Sun X, Zheng C, Wang M, Xu Z, Wang M, Chen J, Guo M, Le R, Wu L, Wang Y, Kou X, Zhao Y, Yin J, Wang H, Mao Z, Gao S, 2022
- Lycorine hydrochloride suppresses stress-induced premature cellular senescence by stabilizing the genome of human cells, Zhang W, Yang J, Chen Y, Xue R, Mao Z, Lu W, Jiang Y, 2021
- Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PKcs inhibitors, Wang C, Tang H, Geng A, Dai B, Zhang H, Sun X, Chen Y, Qiao Z, Zhu H, Yang J, Chen J, He Q, Qin N, Xie J, Tan R, Wan X, Gao S, Jiang Y, Sun FL, Mao Z, 2020
- Fight to the bitter end: DNA repair and aging, Chen Y, Geng A, Zhang W, Qian Z, Wan X, Jiang Y, Mao Z, 2020
- The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2, Geng A, Tang H, Huang J, Qian Z, Qin N, Yao Y, Xu Z, Chen H, Lan L, Xie H, Zhang J, Jiang Y, Mao Z, 2020
- The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells, Chen Y, Chen J, Sun X, Yu J, Qian Z, Wu L, Xu X, Wan X, Jiang Y, Zhang J, Gao S, Mao Z, 2020
- A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing, Zhang W, Chen Y, Yang J, Zhang J, Yu J, Wang M, Zhao X, Wei K, Wan X, Xu X, Jiang Y, Chen J, Gao S, Mao Z, 2020
- Base excision repair but not DNA double strand break repair is impaired in aged human adipose-derived stem cells (ADSCs), Zhang H, Cai B, Geng A, Tang H, Zhang W, Li S, Jiang Y, Tan R, Wan X, Mao Z, 2020
- A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites, Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, SuT, ShiJ, Jiang C, Tian X, SeluanovA, HuangJ, WanX, Jiang Y, Gorbunova V, Mao Z, 2019
- Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion, Tang H, Geng A, Zhang T, Wang C, Jiang Y, Mao Z, 2019
- Nuclear cGAS suppresses DNA repair and promotes tumorigenesis, Liu H, Zhang H, Wu X, Ma D, Wu J, Wang L, Jiang Y, Fei Y, Zhu C, Tan R, Jungblut P, Pei G, Dorhoi A, Yan Q, Zhang F, Zheng R, Liu S, Liang H, Liu Z, Yang H, Chen J, Wang P, Tang T, Peng W, Hu Z, Xu Z, Huang X, Wang J, Li H, Zhou Y, Liu F, Yan D, Kaufmann SH, Chen C, Mao Z, Ge B, 2018
- Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy, Chen Y, Li Z, Xu Z, Tang H, Guo W, Sun X, Zhang W, Zhang J, Wan X, Jiang Y, Mao Z, 2018
- POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions, Yu Y, Tang R, Ren Q, Gao B, Sheng Z, Zhang J, Zheng X, Jiang Y, Li Lan, Mao Z, 2017
- The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression, Zhang F, Tang H, Jiang Y, Mao Z, 2017
- Sirt6 promotes DNA end joining in iPS cells derived from old mice, Chen W, Liu N, Zhang H-X, Zhang H-P, Qiao J, Jia W, Zhu S, Mao Z, Kang J, 2017
- Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans, Li Z, Zhang W, Chen Y, Guo W, Zhang J, Tang H, Xu Z, Zhang H, Tao Y, Wang F, Jiang Y, Sun FL, Mao Z, 2016
- RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1, Chen S, Wang C, Sun L, Wang DL, Chen L, Huang Z, Yang Q, Gao J, Yang XB, Chang JF, Chen P, Lan L, Mao Z, Sun FL, 2015
- SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner, Xu Z, Zhang L, Zhang W, Meng D, Zhang H, Jiang Y, Xu X, Van Meter M, Seluanov A, Gorbunova V, Mao Z, 2015
Awards
- 2013 - Chief Scientist of the National Basic Research Program of China (973 Program)
- 2013 - Shanghai Pujiang Talent Program
- 2016 - National Natural Science Foundation of China for Excellent Young Scientists
- 2019 - Shanghai Leading Academic Discipline Project
- 2021 - Third Prize of Shanghai Medical Science and Technology Award
