2002 - Bachelor's Degree: Nanjing University, School of Life Sciences
2004 - Master's Degree: Nanjing University, School of Life Sciences
2010 - PhD: University of Rochester, USA
National Outstanding Young Scientist Award
Overseas High-level Young Talent
2010-2012 - University of Rochester, Department of Biology: Postdoctoral Researcher
Since 2012 - Tongji University: Head of Research Group
2013 - Chief Scientist of the National Basic Research Program of China (973 Program)
2013 - Shanghai Pujiang Talent Program
2016 - National Natural Science Foundation of China for Excellent Young Scientists
2019 - Shanghai Leading Academic Discipline Project
2021 - Third Prize of Shanghai Medical Science and Technology Award
Research
Aging and related diseases Stem cell genomic stability Development of new methods for delaying aging and treating related diseases
cGAS-Ku80 complex regulates the choice of two nonhomologous end joining pathways, Zhang H, Jiang L, Du X, Qian Z, Wu G, Jiang Y, Mao Z, 2024
SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner, Geng A, Sun J, Tang H, Yu Y, Wang X, Zhang J, Wang X, Sun X, Zhou X, Gao N, Tan R, Xu Z, Jiang Y, Mao Z, 2024
Circadian factors CLOCK and BMAL1 promote nonhomologous end joining and antagonize cellular senescence, Chen Y, Xu X, Chen Z, Chen L, Jiang Y, Mao Z, 2024
Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation, Zhen Z, Chen Y, Wang H, Tang H, Zhang H, Liu H, Jiang Y, Mao Z, 2023
Androgen signaling stabilizes genomes to counteract senescence by promoting XRCC4 transcription, Chen Y, Zhen Z, Chen L, Wang H, Wang X, Sun X, Song Z, Wang H, Lin Y, Zhang W, Wu G, Jiang Y, Mao Z, 2023
Impaired end joining induces cardiac atrophy in a Hutchinson–Gilford progeria mouse model, Chen Y, Huang S, Cui Z, Sun X, Tang Y, Zhang H, Chen Z, Jiang R, Zhang W, Li X, Chen J, Liu B, Jiang Y, Wei K, Mao Z, 2023
Loss of ER/PR/HER2 promotes USP15-dependent stabilization of PARP1 in triple-negative breast cancer, Sun X, Tang H, Chen Y, Chen Z, Hu Z, Cui Z, Tao Y, Yuan J, Fu Y, Zhuang Z, He Q, Li Q, Xu X, Wan X, Jiang Y, Mao Z, 2023
Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer, Zhang W, Wang M, Song Z, Fu Q, Chen J, Zhang W, Gao S, Sun X, Yang G, Zhang Q, Yang J, Tang H, Wang H, Kou X, Wang H, Mao Z, Xu X, Gao S, Jiang Y, 2023
IDDoR: A novel reporter mouse system for simultaneous and quantitative in vivo analysis of both DNA double-strand break repair pathways, Chen Y, Cui Z, Chen Z, Jiang Y, Mao Z, 2022
Enhancement of Xrcc1-mediated base excision repair improves the genetic stability and pluripotency of iPSCs, Zhao K, Sun X, Zheng C, Wang M, Xu Z, Wang M, Chen J, Guo M, Le R, Wu L, Wang Y, Kou X, Zhao Y, Yin J, Wang H, Mao Z, Gao S, 2022
Lycorine hydrochloride suppresses stress-induced premature cellular senescence by stabilizing the genome of human cells, Zhang W, Yang J, Chen Y, Xue R, Mao Z, Lu W, Jiang Y, 2021
Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PKcs inhibitors, Wang C, Tang H, Geng A, Dai B, Zhang H, Sun X, Chen Y, Qiao Z, Zhu H, Yang J, Chen J, He Q, Qin N, Xie J, Tan R, Wan X, Gao S, Jiang Y, Sun FL, Mao Z, 2020
Fight to the bitter end: DNA repair and aging, Chen Y, Geng A, Zhang W, Qian Z, Wan X, Jiang Y, Mao Z, 2020
The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2, Geng A, Tang H, Huang J, Qian Z, Qin N, Yao Y, Xu Z, Chen H, Lan L, Xie H, Zhang J, Jiang Y, Mao Z, 2020
The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells, Chen Y, Chen J, Sun X, Yu J, Qian Z, Wu L, Xu X, Wan X, Jiang Y, Zhang J, Gao S, Mao Z, 2020
A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing, Zhang W, Chen Y, Yang J, Zhang J, Yu J, Wang M, Zhao X, Wei K, Wan X, Xu X, Jiang Y, Chen J, Gao S, Mao Z, 2020
Base excision repair but not DNA double strand break repair is impaired in aged human adipose-derived stem cells (ADSCs), Zhang H, Cai B, Geng A, Tang H, Zhang W, Li S, Jiang Y, Tan R, Wan X, Mao Z, 2020
A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites, Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, SuT, ShiJ, Jiang C, Tian X, SeluanovA, HuangJ, WanX, Jiang Y, Gorbunova V, Mao Z, 2019
Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion, Tang H, Geng A, Zhang T, Wang C, Jiang Y, Mao Z, 2019
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis, Liu H, Zhang H, Wu X, Ma D, Wu J, Wang L, Jiang Y, Fei Y, Zhu C, Tan R, Jungblut P, Pei G, Dorhoi A, Yan Q, Zhang F, Zheng R, Liu S, Liang H, Liu Z, Yang H, Chen J, Wang P, Tang T, Peng W, Hu Z, Xu Z, Huang X, Wang J, Li H, Zhou Y, Liu F, Yan D, Kaufmann SH, Chen C, Mao Z, Ge B, 2018
Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy, Chen Y, Li Z, Xu Z, Tang H, Guo W, Sun X, Zhang W, Zhang J, Wan X, Jiang Y, Mao Z, 2018
POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions, Yu Y, Tang R, Ren Q, Gao B, Sheng Z, Zhang J, Zheng X, Jiang Y, Li Lan, Mao Z, 2017
The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression, Zhang F, Tang H, Jiang Y, Mao Z, 2017
Sirt6 promotes DNA end joining in iPS cells derived from old mice, Chen W, Liu N, Zhang H-X, Zhang H-P, Qiao J, Jia W, Zhu S, Mao Z, Kang J, 2017
Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans, Li Z, Zhang W, Chen Y, Guo W, Zhang J, Tang H, Xu Z, Zhang H, Tao Y, Wang F, Jiang Y, Sun FL, Mao Z, 2016
RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1, Chen S, Wang C, Sun L, Wang DL, Chen L, Huang Z, Yang Q, Gao J, Yang XB, Chang JF, Chen P, Lan L, Mao Z, Sun FL, 2015
SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner, Xu Z, Zhang L, Zhang W, Meng D, Zhang H, Jiang Y, Xu X, Van Meter M, Seluanov A, Gorbunova V, Mao Z, 2015
