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Jianhuang Xue
Life Science
Tongji University
Shanghai
Language: Chinese, English
Dna Modifications
Enzymatic Reactions
Heritable Modifications
Biological Functions
Eukaryotic Organisms
Molecular Mechanisms
Biological Research
Disease Linkage
Aging Process
Epigenetic Clocks
Areas of Focus
- Novel DNA modifications and their functional and regulatory mechanisms
- Role of DNA modifications in diseases and aging
Work Experience
- 2021 - Present - Tongji University, School of Life Sciences and Technology: Distinguished Research Fellow, Doctoral Supervisor
- 2021 - Present - Affiliated Researcher, Tongji Hospital, Tongji University
Academic Background & Achievements
- 2012 - Bachelor of Science: Nanjing University
- 2019 - Doctor of Science: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
- Postdoctoral training at City of Hope National Medical Center, USA
- Recipient of the Wu Rui Award
- Recipient of the CAS Outstanding Doctoral Dissertation Award
Publications
- A vitamin-C-derived DNA modification catalysed by an algal TET homologue, Xue JH, et al., 2019
- Epigenetic marks or not? The discovery of novel DNA modifications in eukaryotes, Meng WY, et al., 2024
- Phosphorylation stabilized TET1 acts as an oncoprotein and therapeutic target in B-cell acute lymphoblastic leukemia, Chen Z, et al., 2023
- Uracil-DNA Glycosylase UNG Promotes Tet-mediated DNA Demethylation, Xue JH, et al., 2016
- RNA Pol II as a sensor of 5caC, Xue JH, et al., 2015
- QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism, Zhao Z, et al., 2023
- TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal, Li Y, et al., 2023
- METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism, Han L, et al., 2023
- METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis, Su R, et al., 2022
- The strand-biased mitochondrial DNA methylome and its regulation by DNMT3A, Dou X, et al., 2019
Awards
- Wu Rui Award: For outstanding contributions in the field
- CAS Outstanding Doctoral Dissertation Award: Recognized for exceptional doctoral thesis
