Professor | Jianhuang Xue | Asia Growth Partners

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Name	Jianhuang Xue
Contact Information	xuejianhuang@tongji.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Jianhuang Xue

Contact Information

xuejianhuang@tongji.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Tongji University
Faculty	Life Sciences
Academic Background & Achievements	2012 - Bachelor of Science: Nanjing University 2019 - Doctor of Science: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences Postdoctoral training at City of Hope National Medical Center, USA Recipient of the Wu Rui Award Recipient of the CAS Outstanding Doctoral Dissertation Award
Work Experience	2021 - Present - Tongji University, School of Life Sciences and Technology: Distinguished Research Fellow, Doctoral Supervisor 2021 - Present - Affiliated Researcher, Tongji Hospital, Tongji University
Awards	Wu Rui Award: For outstanding contributions in the field CAS Outstanding Doctoral Dissertation Award: Recognized for exceptional doctoral thesis

University/Lab Affiliation and Title

Tongji University

Faculty

Life Sciences

Academic Background & Achievements

2012 - Bachelor of Science: Nanjing University
2019 - Doctor of Science: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Postdoctoral training at City of Hope National Medical Center, USA
Recipient of the Wu Rui Award
Recipient of the CAS Outstanding Doctoral Dissertation Award

Work Experience

2021 - Present - Tongji University, School of Life Sciences and Technology: Distinguished Research Fellow, Doctoral Supervisor
2021 - Present - Affiliated Researcher, Tongji Hospital, Tongji University

Awards

Wu Rui Award: For outstanding contributions in the field
CAS Outstanding Doctoral Dissertation Award: Recognized for exceptional doctoral thesis

Areas of Focus	Novel DNA modifications and their functional and regulatory mechanisms Role of DNA modifications in diseases and aging
Publications	A vitamin-C-derived DNA modification catalysed by an algal TET homologue, Xue JH, et al., 2019 Epigenetic marks or not? The discovery of novel DNA modifications in eukaryotes, Meng WY, et al., 2024 Phosphorylation stabilized TET1 acts as an oncoprotein and therapeutic target in B-cell acute lymphoblastic leukemia, Chen Z, et al., 2023 Uracil-DNA Glycosylase UNG Promotes Tet-mediated DNA Demethylation, Xue JH, et al., 2016 RNA Pol II as a sensor of 5caC, Xue JH, et al., 2015 QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism, Zhao Z, et al., 2023 TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal, Li Y, et al., 2023 METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism, Han L, et al., 2023 METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis, Su R, et al., 2022 The strand-biased mitochondrial DNA methylome and its regulation by DNMT3A, Dou X, et al., 2019

Areas of Focus

Novel DNA modifications and their functional and regulatory mechanisms
Role of DNA modifications in diseases and aging

Publications

A vitamin-C-derived DNA modification catalysed by an algal TET homologue, Xue JH, et al., 2019
Epigenetic marks or not? The discovery of novel DNA modifications in eukaryotes, Meng WY, et al., 2024
Phosphorylation stabilized TET1 acts as an oncoprotein and therapeutic target in B-cell acute lymphoblastic leukemia, Chen Z, et al., 2023
Uracil-DNA Glycosylase UNG Promotes Tet-mediated DNA Demethylation, Xue JH, et al., 2016
RNA Pol II as a sensor of 5caC, Xue JH, et al., 2015
QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism, Zhao Z, et al., 2023
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal, Li Y, et al., 2023
METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism, Han L, et al., 2023
METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis, Su R, et al., 2022
The strand-biased mitochondrial DNA methylome and its regulation by DNMT3A, Dou X, et al., 2019

Dna Modifications Enzymatic Reactions Heritable Modifications Biological Functions Eukaryotic Organisms Molecular Mechanisms Biological Research Disease Linkage Aging Process Epigenetic Clocks

Jianhuang Xue - Tongji University

Qiang Zhu - Zhejiang University

Xiaotian Liu - Southern University of Science and Technology

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