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Li Wu
Life Science
Tongji University
Shanghai
Language: Chinese, English
Somatic Cell
Reprogramming
Mechanisms
Pluripotent
Stem Cells
Clinical Applications
In Vitro
Female Reproductive System
Pathophysiology
Regenerative Medicine
Areas of Focus
- Somatic cell reprogramming mechanisms
- Clinical applications of pluripotent stem cells and in vitro modeling of female reproductive system pathophysiology for regenerative medicine
Work Experience
- 2018.02-present - Tongji University Affiliated First Maternity and Infant Health Hospital - Assistant Researcher, Associate Researcher
- 2014.07-2018.01 - Tongji University/Institute of Biophysics, Chinese Academy of Sciences - PhD Student
- 2012.07-2014.06 - Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences - Assistant Researcher
- 2011.07-2012.06 - WuXi AppTec - Researcher
- 2007.09-2011.06 - East China Normal University/Shanghai Institute of Materia Medica, CAS - Master Student
Academic Background & Achievements
- 2014.07-2018.01 PhD in Biochemistry and Molecular Biology, Tongji University/Institute of Biophysics, Chinese Academy of Sciences
- 2007.09-2011.06 Master in Biomedical Science, East China Normal University/Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 2002.09-2006.06 Bachelor of Engineering in Food Engineering, Shihezi University
Publications
- Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics, Chen T, Xu Y, Xu X, Wang J, Qiu Z, Yu Y, Jiang X, Shao W, Bai D, Wang M, Mei S, Cheng T, Wu L, Gao S, Che X, 2024
- Transplantation of the LRP1high subpopulation of human umbilical cord-derived mesenchymal stem cells improves ovarian function in mice with premature ovarian failure and aged mice, Shen J, Wu L, Shi X, Chen G, Liu T, Xu F, Xu X, Kou X, Zhao Y, Wang H, Wang C, Gao S, Xu S, 2024
- Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy, Xi C, Yan Z, Bai D, Zhang Y, Wang B, Han XX, Wu L, Shi X, Hu Z, Tang M, Su Z, Liu Y, Liu B, Yin J, Wang H, Li X, Zhang Y, Gao S, Liu W, 2024
- Identification of transcriptome characteristics of granulosa cells and the possible role of UBE2C in the pathogenesis of premature ovarian insufficiency, Liu D, Guan X, Liu W, Jia Y, Zhou H, Xi C, Zhao M, Fang Y, Wu L, Li K, 2023
- Modeling human pregastrulation development by 3D culture of blastoids generated from primed-to-naïve transitioning intermediates, Tu Z, Bi Y, Zhu X, Liu W, Hu J, Wu L, Mao T, Zhou J, Wang H, Wang H, Gao S, Wang Y, 2023
- Remodeling of H3K9me3 during the pluripotent to totipotent-like state transition, Li H, Sun J, Dong Y, Huang Y, Wu L, Xi C, Su Z, Xiao Y, Zhang C, Liang Y, Li Y, Lin Z, Shen L, Zuo Y, Abudureheman A, Yin J, Wang H, Kong X, Le R, Gao S, Zhang Y, 2023
- LSM1-mediated Major Satellite RNA decay is required for nonequilibrium histone H3.3 incorporation into parental pronuclei, Zhu J, Chen K, Sun YH, Ye W, Liu J, Zhang D, Su N, Wu L, Kou X, Zhao Y, Wang H, Gao S, Kang L, 2023
- Mettl14-driven senescence-associated secretory phenotype facilitates somatic cell reprogramming, Xi C, Sun J, Xu X, Wu Y, Kou X, Zhao Y, Shen J, Dong Y, Chen K, Su Z, Liu D, Ye W, Liu Y, Zhang R, Xu Y, Wang H, Hao L, Wu L, Gao S, 2022
- Enhancement of Xrcc1-mediated base excision repair improves the genetic stability and pluripotency of iPSCs, Zhao K, Sun X, Zheng C, Wang M, Xu Z, Wang M, Chen J, Guo M, Le R, Wu L, Wang Y, Kou X, Zhao Y, Yin J, Wang H, Mao Z, Gao S, Gao S, 2022
- Surf4 facilitates reprogramming by activating the cellular response to endoplasmic reticulum stress, Wu L, He S, Ye W, Shen J, Zhao K, Zhang Y, Zhang R, Wei J, Cao S, Chen K, Le R, Xi C, Kou X, Zhao Y, Wang H, Kang L, Gao S, 2021
- The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells, Chen Y, Chen J, Sun X, Yu J, Qian Z, Wu L, Xu X, Wan X, Jiang Y, Zhang J, Gao S, Mao Z, 2020
- Accurate annotation of accessible chromatin in mouse and human primordial germ cells, Li J, Shen S, Chen J, Liu W, Li X, Zhu Q, Wang B, Chen X, Wu L, Wang M, Gu L, Wang H, Yin J, Jiang C, Gao S, 2018
- Oocyte-Specific Homeobox 1, Obox1, Facilitates Reprogramming by Promoting Mesenchymal-to-Epithelial Transition and mitigating Cell Hyperproliferation, Wu L, Wu Y, Peng B, Hou Z, Dong Y, Chen K, Guo M, Li H, Chen X, Kou X, Zhao Y, Bi Y, Wang Y, Wang H, Le R, Kang L, Gao S, 2017
- Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases, Zhang L, Wang JC, Hou L, Cao PR, Wu L, Zhang QS, Yang HY, Zang Y, Ding JP, Li J, 2015
- Screening of AMPK interacted proteins by yeast two hybrid system, Wu L, Yang C, Deng S, Zhou Y, Qian M, Zang Y, 2012
- 5'-AMP-activated protein kinase (AMPK) regulates progesterone receptor transcriptional activity in breast cancer cells, Wu L, Huang XJ, Yang CH, Deng SS, Qian M, Zang Y, Li J, 2011
