Professor | Li Wu | Asia Growth Partners

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Name	Li Wu
Contact Information	14_wuli@tongji.edu.cn
Language ability	Chinese, English
Province	Shanghai

Upload Avatar (500 x 500)

Name

Li Wu

Contact Information

14_wuli@tongji.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Tongji University
Faculty	Life Sciences
Academic Background & Achievements	2014.07-2018.01 PhD in Biochemistry and Molecular Biology, Tongji University/Institute of Biophysics, Chinese Academy of Sciences 2007.09-2011.06 Master in Biomedical Science, East China Normal University/Shanghai Institute of Materia Medica, Chinese Academy of Sciences 2002.09-2006.06 Bachelor of Engineering in Food Engineering, Shihezi University
Work Experience	2018.02-present - Tongji University Affiliated First Maternity and Infant Health Hospital - Assistant Researcher, Associate Researcher 2014.07-2018.01 - Tongji University/Institute of Biophysics, Chinese Academy of Sciences - PhD Student 2012.07-2014.06 - Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences - Assistant Researcher 2011.07-2012.06 - WuXi AppTec - Researcher 2007.09-2011.06 - East China Normal University/Shanghai Institute of Materia Medica, CAS - Master Student

University/Lab Affiliation and Title

Tongji University

Faculty

Life Sciences

Academic Background & Achievements

2014.07-2018.01 PhD in Biochemistry and Molecular Biology, Tongji University/Institute of Biophysics, Chinese Academy of Sciences
2007.09-2011.06 Master in Biomedical Science, East China Normal University/Shanghai Institute of Materia Medica, Chinese Academy of Sciences
2002.09-2006.06 Bachelor of Engineering in Food Engineering, Shihezi University

Work Experience

2018.02-present - Tongji University Affiliated First Maternity and Infant Health Hospital - Assistant Researcher, Associate Researcher
2014.07-2018.01 - Tongji University/Institute of Biophysics, Chinese Academy of Sciences - PhD Student
2012.07-2014.06 - Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences - Assistant Researcher
2011.07-2012.06 - WuXi AppTec - Researcher
2007.09-2011.06 - East China Normal University/Shanghai Institute of Materia Medica, CAS - Master Student

Areas of Focus	Somatic cell reprogramming mechanisms Clinical applications of pluripotent stem cells and in vitro modeling of female reproductive system pathophysiology for regenerative medicine
Publications	Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics, Chen T, Xu Y, Xu X, Wang J, Qiu Z, Yu Y, Jiang X, Shao W, Bai D, Wang M, Mei S, Cheng T, Wu L, Gao S, Che X, 2024 Transplantation of the LRP1high subpopulation of human umbilical cord-derived mesenchymal stem cells improves ovarian function in mice with premature ovarian failure and aged mice, Shen J, Wu L, Shi X, Chen G, Liu T, Xu F, Xu X, Kou X, Zhao Y, Wang H, Wang C, Gao S, Xu S, 2024 Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy, Xi C, Yan Z, Bai D, Zhang Y, Wang B, Han XX, Wu L, Shi X, Hu Z, Tang M, Su Z, Liu Y, Liu B, Yin J, Wang H, Li X, Zhang Y, Gao S, Liu W, 2024 Identification of transcriptome characteristics of granulosa cells and the possible role of UBE2C in the pathogenesis of premature ovarian insufficiency, Liu D, Guan X, Liu W, Jia Y, Zhou H, Xi C, Zhao M, Fang Y, Wu L, Li K, 2023 Modeling human pregastrulation development by 3D culture of blastoids generated from primed-to-naïve transitioning intermediates, Tu Z, Bi Y, Zhu X, Liu W, Hu J, Wu L, Mao T, Zhou J, Wang H, Wang H, Gao S, Wang Y, 2023 Remodeling of H3K9me3 during the pluripotent to totipotent-like state transition, Li H, Sun J, Dong Y, Huang Y, Wu L, Xi C, Su Z, Xiao Y, Zhang C, Liang Y, Li Y, Lin Z, Shen L, Zuo Y, Abudureheman A, Yin J, Wang H, Kong X, Le R, Gao S, Zhang Y, 2023 LSM1-mediated Major Satellite RNA decay is required for nonequilibrium histone H3.3 incorporation into parental pronuclei, Zhu J, Chen K, Sun YH, Ye W, Liu J, Zhang D, Su N, Wu L, Kou X, Zhao Y, Wang H, Gao S, Kang L, 2023 Mettl14-driven senescence-associated secretory phenotype facilitates somatic cell reprogramming, Xi C, Sun J, Xu X, Wu Y, Kou X, Zhao Y, Shen J, Dong Y, Chen K, Su Z, Liu D, Ye W, Liu Y, Zhang R, Xu Y, Wang H, Hao L, Wu L, Gao S, 2022 Enhancement of Xrcc1-mediated base excision repair improves the genetic stability and pluripotency of iPSCs, Zhao K, Sun X, Zheng C, Wang M, Xu Z, Wang M, Chen J, Guo M, Le R, Wu L, Wang Y, Kou X, Zhao Y, Yin J, Wang H, Mao Z, Gao S, Gao S, 2022 Surf4 facilitates reprogramming by activating the cellular response to endoplasmic reticulum stress, Wu L, He S, Ye W, Shen J, Zhao K, Zhang Y, Zhang R, Wei J, Cao S, Chen K, Le R, Xi C, Kou X, Zhao Y, Wang H, Kang L, Gao S, 2021 The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells, Chen Y, Chen J, Sun X, Yu J, Qian Z, Wu L, Xu X, Wan X, Jiang Y, Zhang J, Gao S, Mao Z, 2020 Accurate annotation of accessible chromatin in mouse and human primordial germ cells, Li J, Shen S, Chen J, Liu W, Li X, Zhu Q, Wang B, Chen X, Wu L, Wang M, Gu L, Wang H, Yin J, Jiang C, Gao S, 2018 Oocyte-Specific Homeobox 1, Obox1, Facilitates Reprogramming by Promoting Mesenchymal-to-Epithelial Transition and mitigating Cell Hyperproliferation, Wu L, Wu Y, Peng B, Hou Z, Dong Y, Chen K, Guo M, Li H, Chen X, Kou X, Zhao Y, Bi Y, Wang Y, Wang H, Le R, Kang L, Gao S, 2017 Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases, Zhang L, Wang JC, Hou L, Cao PR, Wu L, Zhang QS, Yang HY, Zang Y, Ding JP, Li J, 2015 Screening of AMPK interacted proteins by yeast two hybrid system, Wu L, Yang C, Deng S, Zhou Y, Qian M, Zang Y, 2012 5'-AMP-activated protein kinase (AMPK) regulates progesterone receptor transcriptional activity in breast cancer cells, Wu L, Huang XJ, Yang CH, Deng SS, Qian M, Zang Y, Li J, 2011

Areas of Focus

Somatic cell reprogramming mechanisms
Clinical applications of pluripotent stem cells and in vitro modeling of female reproductive system pathophysiology for regenerative medicine

Publications

Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics, Chen T, Xu Y, Xu X, Wang J, Qiu Z, Yu Y, Jiang X, Shao W, Bai D, Wang M, Mei S, Cheng T, Wu L, Gao S, Che X, 2024
Transplantation of the LRP1high subpopulation of human umbilical cord-derived mesenchymal stem cells improves ovarian function in mice with premature ovarian failure and aged mice, Shen J, Wu L, Shi X, Chen G, Liu T, Xu F, Xu X, Kou X, Zhao Y, Wang H, Wang C, Gao S, Xu S, 2024
Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy, Xi C, Yan Z, Bai D, Zhang Y, Wang B, Han XX, Wu L, Shi X, Hu Z, Tang M, Su Z, Liu Y, Liu B, Yin J, Wang H, Li X, Zhang Y, Gao S, Liu W, 2024
Identification of transcriptome characteristics of granulosa cells and the possible role of UBE2C in the pathogenesis of premature ovarian insufficiency, Liu D, Guan X, Liu W, Jia Y, Zhou H, Xi C, Zhao M, Fang Y, Wu L, Li K, 2023
Modeling human pregastrulation development by 3D culture of blastoids generated from primed-to-naïve transitioning intermediates, Tu Z, Bi Y, Zhu X, Liu W, Hu J, Wu L, Mao T, Zhou J, Wang H, Wang H, Gao S, Wang Y, 2023
Remodeling of H3K9me3 during the pluripotent to totipotent-like state transition, Li H, Sun J, Dong Y, Huang Y, Wu L, Xi C, Su Z, Xiao Y, Zhang C, Liang Y, Li Y, Lin Z, Shen L, Zuo Y, Abudureheman A, Yin J, Wang H, Kong X, Le R, Gao S, Zhang Y, 2023
LSM1-mediated Major Satellite RNA decay is required for nonequilibrium histone H3.3 incorporation into parental pronuclei, Zhu J, Chen K, Sun YH, Ye W, Liu J, Zhang D, Su N, Wu L, Kou X, Zhao Y, Wang H, Gao S, Kang L, 2023
Mettl14-driven senescence-associated secretory phenotype facilitates somatic cell reprogramming, Xi C, Sun J, Xu X, Wu Y, Kou X, Zhao Y, Shen J, Dong Y, Chen K, Su Z, Liu D, Ye W, Liu Y, Zhang R, Xu Y, Wang H, Hao L, Wu L, Gao S, 2022
Enhancement of Xrcc1-mediated base excision repair improves the genetic stability and pluripotency of iPSCs, Zhao K, Sun X, Zheng C, Wang M, Xu Z, Wang M, Chen J, Guo M, Le R, Wu L, Wang Y, Kou X, Zhao Y, Yin J, Wang H, Mao Z, Gao S, Gao S, 2022
Surf4 facilitates reprogramming by activating the cellular response to endoplasmic reticulum stress, Wu L, He S, Ye W, Shen J, Zhao K, Zhang Y, Zhang R, Wei J, Cao S, Chen K, Le R, Xi C, Kou X, Zhao Y, Wang H, Kang L, Gao S, 2021
The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells, Chen Y, Chen J, Sun X, Yu J, Qian Z, Wu L, Xu X, Wan X, Jiang Y, Zhang J, Gao S, Mao Z, 2020
Accurate annotation of accessible chromatin in mouse and human primordial germ cells, Li J, Shen S, Chen J, Liu W, Li X, Zhu Q, Wang B, Chen X, Wu L, Wang M, Gu L, Wang H, Yin J, Jiang C, Gao S, 2018
Oocyte-Specific Homeobox 1, Obox1, Facilitates Reprogramming by Promoting Mesenchymal-to-Epithelial Transition and mitigating Cell Hyperproliferation, Wu L, Wu Y, Peng B, Hou Z, Dong Y, Chen K, Guo M, Li H, Chen X, Kou X, Zhao Y, Bi Y, Wang Y, Wang H, Le R, Kang L, Gao S, 2017
Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases, Zhang L, Wang JC, Hou L, Cao PR, Wu L, Zhang QS, Yang HY, Zang Y, Ding JP, Li J, 2015
Screening of AMPK interacted proteins by yeast two hybrid system, Wu L, Yang C, Deng S, Zhou Y, Qian M, Zang Y, 2012
5'-AMP-activated protein kinase (AMPK) regulates progesterone receptor transcriptional activity in breast cancer cells, Wu L, Huang XJ, Yang CH, Deng SS, Qian M, Zang Y, Li J, 2011

Somatic Cell Reprogramming Mechanisms Pluripotent Stem Cells Clinical Applications In Vitro Female Reproductive System Pathophysiology Regenerative Medicine

Xiaolei Yin - Tongji University

Rui Yue - Tongji University

Xuechun Xia - Shanghai Jiao Tong University

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