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Chune Dong
Medical School
Wuhan University
Hubei
Language: Chinese, English
Medicinal Chemistry
Synthesis
Organic Chemistry
Carbon-Heteroatom Bonding
Asymmetric Catalysis
Biomimetics
Ion Channels
Chemical Synthesis
Research
Pharmaceuticals
Areas of Focus
- Synthesis of small molecules with potential medicinal activity
- Research on new methods in organic chemistry, especially carbon-heteroatom bonding and asymmetric catalysis
- Design and synthesis of biomimetic ion channels and study of their activity
Work Experience
- 2000-2001 - University of Vienna, Postdoctoral Researcher
- 2002-2004 - University of Ottawa, Postdoctoral Researcher
- 2004-2006 - University of Illinois at Urbana-Champaign, Postdoctoral Researcher
Academic Background & Achievements
- 2000 - PhD in Organic Chemistry, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences
- Postdoctoral Researcher at University of Vienna, University of Ottawa, and University of Illinois at Urbana-Champaign
Publications
- An Expedient Approach to Highly Enantioenriched Cyclic Nitrones Mediated by Robust and Recoverable C3-Symmetric Cinchonine-Squaramide Catalyst, Chune Dong*, 2012
- A New Pathway for Phthalazine Derivatives via Metal-free Cyclization of ortho-Alkynylphenyl ketones and Hydrazine, Chune Dong*, 2013
- A simple and straightforward approach toward selective C=C bond reduction by hydrazine, Chune Dong*, 2012
- Enhanced efficiency of recyclable C3-symmetric cinchonine-squaramides in the asymmetric Friedel-Crafts reaction of indole with alkyl trifluoro pyruvate, Chune Dong*, 2012
- Chiral Squaramide as Multiple H-Bonds Donor Organocatalyst for Asymmetric Michael addition of 1, 3-Dicarbonyl Compounds to Nitroolefins, Chune Dong*, 2012
- Identification and structure-Activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo[2,2,1]hept-2-ene-7-oxide, Chune Dong, 2012
- C3-symmetric cinchonine-squaramide as new highly efficient and recyclable organocatalyst for enantioselective michael addition, Chune Dong*, 2011
- A Novel C3-Symmetric Prolinol-Squaramide Catalyst for the Asymmetric Reduction of Ketones by Borane, Chune Dong*, 2011
- Novel bifunctional chiral squaramide-amine catalysts for highly enantioselective addition of mono diketones to nitroalkenes, Chune Dong*, 2011
- Facile synthesis of 1,3,4-benzotriazepines and 1-arylamide-1H-indazoles via palladium catalyzed cyclization of aryl isocyanates and aryl hydrazones under microwave irradiation, Chune Dong*, 2010
- Discovery of novel SERMs with a ferrocenyl entity based on the oxabicyclo [2.2.1]hepte-ne scaffold and evaluation of their antiproliferative effects, Chune Dong, 2012
- Biocyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfon-amides, Chune Dong, 2012
- Development of selective estrogen receptor modulator SERM-like activity through an indirect mechanism of estrogen receptor antagonism defining the binding mode of 7-oxabicyclo[2.2.1] hept-5-ene scaffold core ligands, Chune Dong, 2012
- Progress in small molecular inhibitors of protein protein interactions, Chune Dong*, 2010
