Professor | Peng Chen | Asia Growth Partners

	Upload Avatar (500 x 500)
Name	Peng Chen
Contact Information	pengch@whu.edu.cn
Language ability	Chinese, English
Province	Hubei

Upload Avatar (500 x 500)

Name

Peng Chen

Contact Information

pengch@whu.edu.cn

Language ability

Chinese, English

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Medical School
Academic Background & Achievements	2008 - 2013 PhD in Biochemistry and Molecular Biology, University of Science and Technology of China 2004 - 2008 Bachelor in Biological Sciences, Northeast Normal University
Work Experience	2021.11 - Present, Wuhan University, School of Pharmaceutical Sciences, Professor 2019.05 - 2021.11, University of California, Irvine, School of Medicine/Department of Physiology and Biophysics, Assistant Project Scientist 2014.05 - 2019.05, University of California, Irvine, School of Medicine/Department of Physiology and Biophysics, Postdoctoral Researcher

University/Lab Affiliation and Title

Wuhan University

Faculty

Medical School

Academic Background & Achievements

2008 - 2013 PhD in Biochemistry and Molecular Biology, University of Science and Technology of China
2004 - 2008 Bachelor in Biological Sciences, Northeast Normal University

Work Experience

2021.11 - Present, Wuhan University, School of Pharmaceutical Sciences, Professor
2019.05 - 2021.11, University of California, Irvine, School of Medicine/Department of Physiology and Biophysics, Assistant Project Scientist
2014.05 - 2019.05, University of California, Irvine, School of Medicine/Department of Physiology and Biophysics, Postdoctoral Researcher

Areas of Focus	Molecular mechanisms of interaction between pathogen effectors and hosts Structure-based drug development and vaccine design
Publications	Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B, Chen, P., Tao, L., Wang, T., Zhang, J., He, A., Lam, K. H., Liu, Z., He, X., Perry, K., Dong, M., Jin, R., 2018 Structure of the full-length Clostridium difficile toxin B, Chen, P., Lam, K. H., Liu, Z., Mindlin, F. A., Chen, B., Gutierrez, C. B., Huang, L., Zhang, Y., Hamza, T., Feng, H., Matsui, T., Bowen, M. E., Perry, K., Jin, R., 2019 Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection, Chen, P., Zeng, J., Liu, Z., Thaker, H., Wang, S., Tian, S., Zhang, J., Tao, L., Gutierrez, C. B., Xing, L., Gerhard, Ralf., Huang, L., Dong, M., Jin, R., 2021 Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B, Chen, P., Tao, L., Liu, Z., Dong, M., Jin, R., 2019 Receptor binding mechanisms of Clostridioides difficile toxin B and implications for therapeutics development, Chen, P., Jin, R., 2021 Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations, Chen, P., Liu, Z., Wang, X., Peng, J., Sun, Q., Li, J., Wang, M., Niu, L., Zhang, Z., Cai, G., Teng, M., Li, X., 2015 A Small Disturbance, But a Serious Disease: The Possible Mechanism of D52H-Mutant of Human PRS1 That Causes Gout, Chen, P., Li, J., Ma, J., Teng, M., Li, X., 2013 Crystal structure of DnaT(84-153)-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode, Liu, Z., Chen, P., Wang, X., Cai, G., Niu, L., Teng, M., Li, X., 2014 Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B, Liu, Z., Zhang, S., Chen, P., Tian, S., Zeng, J., Perry, K., Dong, M., Jin, R., 2021

Areas of Focus

Molecular mechanisms of interaction between pathogen effectors and hosts
Structure-based drug development and vaccine design

Publications

Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B, Chen, P., Tao, L., Wang, T., Zhang, J., He, A., Lam, K. H., Liu, Z., He, X., Perry, K., Dong, M., Jin, R., 2018
Structure of the full-length Clostridium difficile toxin B, Chen, P., Lam, K. H., Liu, Z., Mindlin, F. A., Chen, B., Gutierrez, C. B., Huang, L., Zhang, Y., Hamza, T., Feng, H., Matsui, T., Bowen, M. E., Perry, K., Jin, R., 2019
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection, Chen, P., Zeng, J., Liu, Z., Thaker, H., Wang, S., Tian, S., Zhang, J., Tao, L., Gutierrez, C. B., Xing, L., Gerhard, Ralf., Huang, L., Dong, M., Jin, R., 2021
Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B, Chen, P., Tao, L., Liu, Z., Dong, M., Jin, R., 2019
Receptor binding mechanisms of Clostridioides difficile toxin B and implications for therapeutics development, Chen, P., Jin, R., 2021
Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations, Chen, P., Liu, Z., Wang, X., Peng, J., Sun, Q., Li, J., Wang, M., Niu, L., Zhang, Z., Cai, G., Teng, M., Li, X., 2015
A Small Disturbance, But a Serious Disease: The Possible Mechanism of D52H-Mutant of Human PRS1 That Causes Gout, Chen, P., Li, J., Ma, J., Teng, M., Li, X., 2013
Crystal structure of DnaT(84-153)-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode, Liu, Z., Chen, P., Wang, X., Cai, G., Niu, L., Teng, M., Li, X., 2014
Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B, Liu, Z., Zhang, S., Chen, P., Tian, S., Zeng, J., Perry, K., Dong, M., Jin, R., 2021

Pathogens Effectors Hosts Molecular Mechanisms Interaction Drug Development Vaccine Design Structure-Based Targeted Therapeutics

Wanqiu Li - Southern University of Science and Technology

Xiaohui Zhou - Southern University of Science and Technology

Ji Yanxiao - Wuhan University

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us