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Peng Chen
Medical School
Wuhan University
Hubei
Language: Chinese, English
Pathogens
Effectors
Hosts
Molecular Mechanisms
Interaction
Drug Development
Vaccine Design
Structure-Based
Targeted
Therapeutics
Areas of Focus
- Molecular mechanisms of interaction between pathogen effectors and hosts
- Structure-based drug development and vaccine design
Work Experience
- 2021.11 - Present, Wuhan University, School of Pharmaceutical Sciences, Professor
- 2019.05 - 2021.11, University of California, Irvine, School of Medicine/Department of Physiology and Biophysics, Assistant Project Scientist
- 2014.05 - 2019.05, University of California, Irvine, School of Medicine/Department of Physiology and Biophysics, Postdoctoral Researcher
Academic Background & Achievements
- 2008 - 2013 PhD in Biochemistry and Molecular Biology, University of Science and Technology of China
- 2004 - 2008 Bachelor in Biological Sciences, Northeast Normal University
Publications
- Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B, Chen, P., Tao, L., Wang, T., Zhang, J., He, A., Lam, K. H., Liu, Z., He, X., Perry, K., Dong, M., Jin, R., 2018
- Structure of the full-length Clostridium difficile toxin B, Chen, P., Lam, K. H., Liu, Z., Mindlin, F. A., Chen, B., Gutierrez, C. B., Huang, L., Zhang, Y., Hamza, T., Feng, H., Matsui, T., Bowen, M. E., Perry, K., Jin, R., 2019
- Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection, Chen, P., Zeng, J., Liu, Z., Thaker, H., Wang, S., Tian, S., Zhang, J., Tao, L., Gutierrez, C. B., Xing, L., Gerhard, Ralf., Huang, L., Dong, M., Jin, R., 2021
- Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B, Chen, P., Tao, L., Liu, Z., Dong, M., Jin, R., 2019
- Receptor binding mechanisms of Clostridioides difficile toxin B and implications for therapeutics development, Chen, P., Jin, R., 2021
- Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations, Chen, P., Liu, Z., Wang, X., Peng, J., Sun, Q., Li, J., Wang, M., Niu, L., Zhang, Z., Cai, G., Teng, M., Li, X., 2015
- A Small Disturbance, But a Serious Disease: The Possible Mechanism of D52H-Mutant of Human PRS1 That Causes Gout, Chen, P., Li, J., Ma, J., Teng, M., Li, X., 2013
- Crystal structure of DnaT(84-153)-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode, Liu, Z., Chen, P., Wang, X., Cai, G., Niu, L., Teng, M., Li, X., 2014
- Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B, Liu, Z., Zhang, S., Chen, P., Tian, S., Zeng, J., Perry, K., Dong, M., Jin, R., 2021
